Insulin-like growth factor-1 (IGF-1) empowering tendon regenerative therapies
Tendon injury is one of the most common musculoskeletal disorders that severely affect patients’ daily lives. Unfortunately, naturally healed tendons exhibit poor quality, as they have very limited regenerative ability. Recently, therapeutic strategies involving the administration of growth factors...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-03-01
|
| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1492811/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850206750930632704 |
|---|---|
| author | Mingming Wang Jiayuan Zhang Hanyue Li Yini Li Zhigang Li |
| author_facet | Mingming Wang Jiayuan Zhang Hanyue Li Yini Li Zhigang Li |
| author_sort | Mingming Wang |
| collection | DOAJ |
| description | Tendon injury is one of the most common musculoskeletal disorders that severely affect patients’ daily lives. Unfortunately, naturally healed tendons exhibit poor quality, as they have very limited regenerative ability. Recently, therapeutic strategies involving the administration of growth factors have been advocated to enhance tendon regenerative healing. Growth factors are peptide-signaling molecules that elicit biological functions such as cell proliferation, migration, and differentiation by acting through a complex organization of cell surface receptors and activating intracellular signaling pathways. Insulin-like growth factor-1(IGF-1) represents one such factor that has shown promising effects for enhancing tendon regenerative healing in vitro and animal models. However, it is disappointing that IGF-1 has not been shown to play a very significant role in promoting tendon healing in clinical trials, which could reflect our poor understanding of the molecular mechanisms by which IGF-1 is involved in promoting tendon regenerative healing. Therefore, in this review, we summarized the roles and mechanisms of IGF-1 for enhancing tendon regenerative healing. Nevertheless, much work is still needed to optimize its effectiveness. |
| format | Article |
| id | doaj-art-34f506c92b2245d1a5d6867945f171d0 |
| institution | OA Journals |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-34f506c92b2245d1a5d6867945f171d02025-08-20T02:10:42ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-03-011310.3389/fbioe.2025.14928111492811Insulin-like growth factor-1 (IGF-1) empowering tendon regenerative therapiesMingming Wang0Jiayuan Zhang1Hanyue Li2Yini Li3Zhigang Li4Police Basic Skills Teaching Department, Sichuan Police College, Luzhou, Sichuan, ChinaPolice Basic Skills Teaching Department, Sichuan Police College, Luzhou, Sichuan, ChinaSchool of Physical Education, Southwest Medical University, Luzhou, Sichuan, ChinaThe Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaSchool of Physical Education, Southwest Medical University, Luzhou, Sichuan, ChinaTendon injury is one of the most common musculoskeletal disorders that severely affect patients’ daily lives. Unfortunately, naturally healed tendons exhibit poor quality, as they have very limited regenerative ability. Recently, therapeutic strategies involving the administration of growth factors have been advocated to enhance tendon regenerative healing. Growth factors are peptide-signaling molecules that elicit biological functions such as cell proliferation, migration, and differentiation by acting through a complex organization of cell surface receptors and activating intracellular signaling pathways. Insulin-like growth factor-1(IGF-1) represents one such factor that has shown promising effects for enhancing tendon regenerative healing in vitro and animal models. However, it is disappointing that IGF-1 has not been shown to play a very significant role in promoting tendon healing in clinical trials, which could reflect our poor understanding of the molecular mechanisms by which IGF-1 is involved in promoting tendon regenerative healing. Therefore, in this review, we summarized the roles and mechanisms of IGF-1 for enhancing tendon regenerative healing. Nevertheless, much work is still needed to optimize its effectiveness.https://www.frontiersin.org/articles/10.3389/fbioe.2025.1492811/fulltendon injuryIGF-1tendon regenerative healingtendon repairtenocytemechanisms |
| spellingShingle | Mingming Wang Jiayuan Zhang Hanyue Li Yini Li Zhigang Li Insulin-like growth factor-1 (IGF-1) empowering tendon regenerative therapies Frontiers in Bioengineering and Biotechnology tendon injury IGF-1 tendon regenerative healing tendon repair tenocyte mechanisms |
| title | Insulin-like growth factor-1 (IGF-1) empowering tendon regenerative therapies |
| title_full | Insulin-like growth factor-1 (IGF-1) empowering tendon regenerative therapies |
| title_fullStr | Insulin-like growth factor-1 (IGF-1) empowering tendon regenerative therapies |
| title_full_unstemmed | Insulin-like growth factor-1 (IGF-1) empowering tendon regenerative therapies |
| title_short | Insulin-like growth factor-1 (IGF-1) empowering tendon regenerative therapies |
| title_sort | insulin like growth factor 1 igf 1 empowering tendon regenerative therapies |
| topic | tendon injury IGF-1 tendon regenerative healing tendon repair tenocyte mechanisms |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1492811/full |
| work_keys_str_mv | AT mingmingwang insulinlikegrowthfactor1igf1empoweringtendonregenerativetherapies AT jiayuanzhang insulinlikegrowthfactor1igf1empoweringtendonregenerativetherapies AT hanyueli insulinlikegrowthfactor1igf1empoweringtendonregenerativetherapies AT yinili insulinlikegrowthfactor1igf1empoweringtendonregenerativetherapies AT zhigangli insulinlikegrowthfactor1igf1empoweringtendonregenerativetherapies |