Dynamic crosstalk between HSCs and liver microenvironment: multicellular interactions in the regulation of liver fibrosis

Dynamic crosstalk between HSCs and liver microenvironment: multicellular interactions in the regulation of liver fibrosis

Liver fibrosis is induced by persistent stimulation of various factors, resulting from complex multicellular interactions and multifactorial networks. Without intervention, it can progress to cirrhosis and even liver cancer. Current understanding suggests that liver fibrosis is reversible, making it...

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Bibliographic Details
Main Authors: Luping Wang, Yi Huang, Jingrong Chen, Jialu Gao, Sihan Chen, Mingqi Zhao, Jiguo Lin, Shunqing Zhou, Yannan Shen, Yunyun Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
liver fibrosis
hepatic stellate cells
cell communications
hepatic immune cells
intercellular signal transduction
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1635763/full
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