Subretinal fluid in eyes with active ocular toxoplasmosis observed using spectral domain optical coherence tomography.
<h4>Purpose</h4>To describe the clinical finding of subretinal fluid (SRF) in the posterior pole by spectral domain optical coherence tomography (SD-OCT) in eyes with active ocular toxoplasmosis (OT).<h4>Design</h4>Retrospective case series.<h4>Participants</h4>Th...
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| Format: | Article |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0127683 |
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| author | Yanling Ouyang Fuqiang Li Qing Shao Florian M Heussen Pearse A Keane Nicole Stübiger Srinivas R Sadda Uwe Pleyer |
| author_facet | Yanling Ouyang Fuqiang Li Qing Shao Florian M Heussen Pearse A Keane Nicole Stübiger Srinivas R Sadda Uwe Pleyer |
| author_sort | Yanling Ouyang |
| collection | DOAJ |
| description | <h4>Purpose</h4>To describe the clinical finding of subretinal fluid (SRF) in the posterior pole by spectral domain optical coherence tomography (SD-OCT) in eyes with active ocular toxoplasmosis (OT).<h4>Design</h4>Retrospective case series.<h4>Participants</h4>Thirty-nine eyes from 38 patients with active OT [corrected]..<h4>Methods</h4>Eyes with active OT which underwent SD-OCT were reviewed. SRFs in the posterior pole were further analyzed.<h4>Main outcome measures</h4>Presence of SRF; its accompanying features, e.g. retinal necrosis, cystoid macular edema (CME), choroidal neovascularization (CNV); and longitudinal changes of SRF, including maximum height and total volume before and after treatment.<h4>Results</h4>SRF presented in 45.5% (or 15/33) of eyes with typical active OT and in 51.3% (or 20/39) of eyes with active OT. The mean maximum height and total volume of SRF were 161.0 (range: 23-478) µm and 0.47 (range: 0.005-4.12) mm3, respectively. For 12 eyes with SRF related to active retinal necrosis, SRF was observed with complete absorption after conventional anti-toxoplasmosis treatment. The mean duration for observation of SRF clearance was 33.8 (range: 7-84) days. The mean rate of SRF clearance was 0.0128 (range: 0.0002-0.0665) mm3/day.<h4>Conclusions</h4>SRF (i.e., serous retinal detachment) is a common feature in patients with active OT when SD-OCT is performed. The majority of SRF was associated with retinal necrosis and reacted well to conventional therapy, regardless of total fluid volume. However, SRF accompanying with CME or CNV responded less favorably or remained refractory to conventional or combined intravitreal treatment, even when the SRF was small in size. |
| format | Article |
| id | doaj-art-34e566e4beb54fb98fc0333a653fb5fe |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-34e566e4beb54fb98fc0333a653fb5fe2025-08-20T02:34:10ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01105e012768310.1371/journal.pone.0127683Subretinal fluid in eyes with active ocular toxoplasmosis observed using spectral domain optical coherence tomography.Yanling OuyangFuqiang LiQing ShaoFlorian M HeussenPearse A KeaneNicole StübigerSrinivas R SaddaUwe Pleyer<h4>Purpose</h4>To describe the clinical finding of subretinal fluid (SRF) in the posterior pole by spectral domain optical coherence tomography (SD-OCT) in eyes with active ocular toxoplasmosis (OT).<h4>Design</h4>Retrospective case series.<h4>Participants</h4>Thirty-nine eyes from 38 patients with active OT [corrected]..<h4>Methods</h4>Eyes with active OT which underwent SD-OCT were reviewed. SRFs in the posterior pole were further analyzed.<h4>Main outcome measures</h4>Presence of SRF; its accompanying features, e.g. retinal necrosis, cystoid macular edema (CME), choroidal neovascularization (CNV); and longitudinal changes of SRF, including maximum height and total volume before and after treatment.<h4>Results</h4>SRF presented in 45.5% (or 15/33) of eyes with typical active OT and in 51.3% (or 20/39) of eyes with active OT. The mean maximum height and total volume of SRF were 161.0 (range: 23-478) µm and 0.47 (range: 0.005-4.12) mm3, respectively. For 12 eyes with SRF related to active retinal necrosis, SRF was observed with complete absorption after conventional anti-toxoplasmosis treatment. The mean duration for observation of SRF clearance was 33.8 (range: 7-84) days. The mean rate of SRF clearance was 0.0128 (range: 0.0002-0.0665) mm3/day.<h4>Conclusions</h4>SRF (i.e., serous retinal detachment) is a common feature in patients with active OT when SD-OCT is performed. The majority of SRF was associated with retinal necrosis and reacted well to conventional therapy, regardless of total fluid volume. However, SRF accompanying with CME or CNV responded less favorably or remained refractory to conventional or combined intravitreal treatment, even when the SRF was small in size.https://doi.org/10.1371/journal.pone.0127683 |
| spellingShingle | Yanling Ouyang Fuqiang Li Qing Shao Florian M Heussen Pearse A Keane Nicole Stübiger Srinivas R Sadda Uwe Pleyer Subretinal fluid in eyes with active ocular toxoplasmosis observed using spectral domain optical coherence tomography. PLoS ONE |
| title | Subretinal fluid in eyes with active ocular toxoplasmosis observed using spectral domain optical coherence tomography. |
| title_full | Subretinal fluid in eyes with active ocular toxoplasmosis observed using spectral domain optical coherence tomography. |
| title_fullStr | Subretinal fluid in eyes with active ocular toxoplasmosis observed using spectral domain optical coherence tomography. |
| title_full_unstemmed | Subretinal fluid in eyes with active ocular toxoplasmosis observed using spectral domain optical coherence tomography. |
| title_short | Subretinal fluid in eyes with active ocular toxoplasmosis observed using spectral domain optical coherence tomography. |
| title_sort | subretinal fluid in eyes with active ocular toxoplasmosis observed using spectral domain optical coherence tomography |
| url | https://doi.org/10.1371/journal.pone.0127683 |
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