Understanding Aortic Stenosis and Transcatheter Aortic Valve Replacement in Women
The impact of sex on the baseline characteristics, morphology, and clinical presentation of degenerative aortic stenosis (AS) is well-documented but remains poorly understood. Unlike valve surgery, for which patients have been predominantly male, percutaneous treatment of AS has shown balanced repre...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-07-01
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| Series: | Structural Heart |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2474870625002581 |
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| author | Giulia Masiero, MD Anna Franzone, MD, PhD Valeria Paradies, MD Nicole Karam, MD, PhD Chiara Fraccaro, MD, PhD Chiara De Biase, MD Mirvat Alasnag, MD Giulia Botti, MD Angelicarosa Cascone, MD Ana Belen Cid-Alvarez, MD, PhD Tanja K. Rudolph, MD, PhD Marta Kaluzna-Oleksy, MD, PhD Stephane Manzo-Silberman, MD, PhD Julinda Mehilli, MD, PhD Barbara E. Stähli, MD, PhD Julia Grapsa, MD, PhD Kyriakos Panaou, MD Barbara Bellini, MD Joanna J. Wykrzykowska, MD, PhD Sabine Bleiziffer, MD, PhD Helene Eltchaninoff, MD, PhD Martine Gilard, MD, PhD Alaide Chieffo, MD, PhD |
| author_facet | Giulia Masiero, MD Anna Franzone, MD, PhD Valeria Paradies, MD Nicole Karam, MD, PhD Chiara Fraccaro, MD, PhD Chiara De Biase, MD Mirvat Alasnag, MD Giulia Botti, MD Angelicarosa Cascone, MD Ana Belen Cid-Alvarez, MD, PhD Tanja K. Rudolph, MD, PhD Marta Kaluzna-Oleksy, MD, PhD Stephane Manzo-Silberman, MD, PhD Julinda Mehilli, MD, PhD Barbara E. Stähli, MD, PhD Julia Grapsa, MD, PhD Kyriakos Panaou, MD Barbara Bellini, MD Joanna J. Wykrzykowska, MD, PhD Sabine Bleiziffer, MD, PhD Helene Eltchaninoff, MD, PhD Martine Gilard, MD, PhD Alaide Chieffo, MD, PhD |
| author_sort | Giulia Masiero, MD |
| collection | DOAJ |
| description | The impact of sex on the baseline characteristics, morphology, and clinical presentation of degenerative aortic stenosis (AS) is well-documented but remains poorly understood. Unlike valve surgery, for which patients have been predominantly male, percutaneous treatment of AS has shown balanced representation of both sexes, with women demonstrating greater benefit from transfemoral aortic valve replacement compared to surgical treatment. This review explores sex-specific differences in the epidemiology, pathophysiology, diagnostic challenges, treatment approaches, and clinical outcomes of degenerative AS. Furthermore, it addresses technical, sex-specific considerations in transfemoral aortic valve replacement, including preprocedural screening, device selection, implantation strategy, and postprocedural management. |
| format | Article |
| id | doaj-art-34e2833b05c54ffc93d2b259c6bdbf51 |
| institution | OA Journals |
| issn | 2474-8706 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Structural Heart |
| spelling | doaj-art-34e2833b05c54ffc93d2b259c6bdbf512025-08-20T02:36:39ZengElsevierStructural Heart2474-87062025-07-019710066610.1016/j.shj.2025.100666Understanding Aortic Stenosis and Transcatheter Aortic Valve Replacement in WomenGiulia Masiero, MD0Anna Franzone, MD, PhD1Valeria Paradies, MD2Nicole Karam, MD, PhD3Chiara Fraccaro, MD, PhD4Chiara De Biase, MD5Mirvat Alasnag, MD6Giulia Botti, MD7Angelicarosa Cascone, MD8Ana Belen Cid-Alvarez, MD, PhD9Tanja K. Rudolph, MD, PhD10Marta Kaluzna-Oleksy, MD, PhD11Stephane Manzo-Silberman, MD, PhD12Julinda Mehilli, MD, PhD13Barbara E. Stähli, MD, PhD14Julia Grapsa, MD, PhD15Kyriakos Panaou, MD16Barbara Bellini, MD17Joanna J. Wykrzykowska, MD, PhD18Sabine Bleiziffer, MD, PhD19Helene Eltchaninoff, MD, PhD20Martine Gilard, MD, PhD21Alaide Chieffo, MD, PhD22Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua Medical School, Padua, ItalyDivision of Cardiology, Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, ItalyDepartment of Cardiology, Maasstad Hospital, Rotterdam, the NetherlandsDepartment of Cardiology, European Hospital Georges Pompidou, Paris, France; Paris Cardiovascular Research Center, Université Paris Cité, INSERM UMRS-970, Paris, FranceDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua Medical School, Padua, ItalyDepartment of Cardiology, Clinique Pasteur, Toulouse, FranceCardiac Center, King Fahd Armed Forces Hospital, Jeddah, Saudi ArabiaVita-Salute San Raffaele University, Milan, ItalyVita-Salute San Raffaele University, Milan, ItalyComplejo Hospitalario Universitario de Santiago de Compostela, CIBERCVClinic for General and Interventional Cardiology/Angiology, Heart and Diabetes Center NRW, Bad Oeynhausen, Ruhr-University and University of Bielefeld, Germany1st Department of Cardiology, Poznan University of Medical Sciences, Poznan, PolandInstitute of Cardiology Hôpital Pitié-Salpêtrière (AP-HP), Sorbonne University, ACTION Study Group, Paris, FranceMedizinische Klinik I, LAKUMED Hospital Landshut.-Achdorf, Landshut, Germany; Ludwig-Maximialis University Clinic, Munich, GermanyDepartment of Cardiology, University Hospital Zurich and University of Zurich, Zurich, SwitzerlandDepartment of Cardiology, Guys and St Thomas NHS Trust, London, UKUniversity Medical Center Groningen, University of Groningen, Groningen, The NetherlandsInterventional Cardiology Unit, IRCCS San Raffaele, Hospital, Milan, ItalyUniversity Medical Center Groningen, University of Groningen, Groningen, The NetherlandsDepartment of Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, University Hospital Ruhr-University Bochum, Bad Oeynhausen, GermanyDepartment of Cardiology, University of Rouen Normandie, Inserm U1096, CHU Rouen, Rouen, FranceINSERM UMR 1304, University of Brest, Brest, FranceVita-Salute San Raffaele University, Milan, Italy; Department of Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, University Hospital Ruhr-University Bochum, Bad Oeynhausen, Germany; Address correspondence to: Alaide Chieffo, MD, PhD, Interventional Cardiology Unit, IRCCS San Raffaele Scientific Institute, 60, Via Olgettina, Milan 20132, Italy.The impact of sex on the baseline characteristics, morphology, and clinical presentation of degenerative aortic stenosis (AS) is well-documented but remains poorly understood. Unlike valve surgery, for which patients have been predominantly male, percutaneous treatment of AS has shown balanced representation of both sexes, with women demonstrating greater benefit from transfemoral aortic valve replacement compared to surgical treatment. This review explores sex-specific differences in the epidemiology, pathophysiology, diagnostic challenges, treatment approaches, and clinical outcomes of degenerative AS. Furthermore, it addresses technical, sex-specific considerations in transfemoral aortic valve replacement, including preprocedural screening, device selection, implantation strategy, and postprocedural management.http://www.sciencedirect.com/science/article/pii/S2474870625002581Aortic stenosisClinical managementDevice selectionSex differencesTranscatheter aortic valve implantation |
| spellingShingle | Giulia Masiero, MD Anna Franzone, MD, PhD Valeria Paradies, MD Nicole Karam, MD, PhD Chiara Fraccaro, MD, PhD Chiara De Biase, MD Mirvat Alasnag, MD Giulia Botti, MD Angelicarosa Cascone, MD Ana Belen Cid-Alvarez, MD, PhD Tanja K. Rudolph, MD, PhD Marta Kaluzna-Oleksy, MD, PhD Stephane Manzo-Silberman, MD, PhD Julinda Mehilli, MD, PhD Barbara E. Stähli, MD, PhD Julia Grapsa, MD, PhD Kyriakos Panaou, MD Barbara Bellini, MD Joanna J. Wykrzykowska, MD, PhD Sabine Bleiziffer, MD, PhD Helene Eltchaninoff, MD, PhD Martine Gilard, MD, PhD Alaide Chieffo, MD, PhD Understanding Aortic Stenosis and Transcatheter Aortic Valve Replacement in Women Structural Heart Aortic stenosis Clinical management Device selection Sex differences Transcatheter aortic valve implantation |
| title | Understanding Aortic Stenosis and Transcatheter Aortic Valve Replacement in Women |
| title_full | Understanding Aortic Stenosis and Transcatheter Aortic Valve Replacement in Women |
| title_fullStr | Understanding Aortic Stenosis and Transcatheter Aortic Valve Replacement in Women |
| title_full_unstemmed | Understanding Aortic Stenosis and Transcatheter Aortic Valve Replacement in Women |
| title_short | Understanding Aortic Stenosis and Transcatheter Aortic Valve Replacement in Women |
| title_sort | understanding aortic stenosis and transcatheter aortic valve replacement in women |
| topic | Aortic stenosis Clinical management Device selection Sex differences Transcatheter aortic valve implantation |
| url | http://www.sciencedirect.com/science/article/pii/S2474870625002581 |
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