Understanding Aortic Stenosis and Transcatheter Aortic Valve Replacement in Women

Understanding Aortic Stenosis and Transcatheter Aortic Valve Replacement in Women

The impact of sex on the baseline characteristics, morphology, and clinical presentation of degenerative aortic stenosis (AS) is well-documented but remains poorly understood. Unlike valve surgery, for which patients have been predominantly male, percutaneous treatment of AS has shown balanced repre...

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Main Authors: Giulia Masiero, MD, Anna Franzone, MD, PhD, Valeria Paradies, MD, Nicole Karam, MD, PhD, Chiara Fraccaro, MD, PhD, Chiara De Biase, MD, Mirvat Alasnag, MD, Giulia Botti, MD, Angelicarosa Cascone, MD, Ana Belen Cid-Alvarez, MD, PhD, Tanja K. Rudolph, MD, PhD, Marta Kaluzna-Oleksy, MD, PhD, Stephane Manzo-Silberman, MD, PhD, Julinda Mehilli, MD, PhD, Barbara E. Stähli, MD, PhD, Julia Grapsa, MD, PhD, Kyriakos Panaou, MD, Barbara Bellini, MD, Joanna J. Wykrzykowska, MD, PhD, Sabine Bleiziffer, MD, PhD, Helene Eltchaninoff, MD, PhD, Martine Gilard, MD, PhD, Alaide Chieffo, MD, PhD
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Structural Heart
Subjects:
Aortic stenosis
Clinical management
Device selection
Sex differences
Transcatheter aortic valve implantation
Online Access:http://www.sciencedirect.com/science/article/pii/S2474870625002581
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Summary:The impact of sex on the baseline characteristics, morphology, and clinical presentation of degenerative aortic stenosis (AS) is well-documented but remains poorly understood. Unlike valve surgery, for which patients have been predominantly male, percutaneous treatment of AS has shown balanced representation of both sexes, with women demonstrating greater benefit from transfemoral aortic valve replacement compared to surgical treatment. This review explores sex-specific differences in the epidemiology, pathophysiology, diagnostic challenges, treatment approaches, and clinical outcomes of degenerative AS. Furthermore, it addresses technical, sex-specific considerations in transfemoral aortic valve replacement, including preprocedural screening, device selection, implantation strategy, and postprocedural management.
ISSN:2474-8706

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