Epidemiology of atrial fibrillation in the All of Us Research Program.
<h4>Background</h4>The prevalence, incidence and risk factors of atrial fibrillation (AF) in a large, geographically and ethnically diverse cohort in the United States have not been fully described.<h4>Methods</h4>We analyzed data from 173,099 participants of the All of Us Re...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0265498 |
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| author | Alvaro Alonso Aniqa B Alam Hooman Kamel Vignesh Subbian Jun Qian Eric Boerwinkle Mine Cicek Cheryl R Clark Elizabeth G Cohn Kelly A Gebo Roxana Loperena-Cortes Kelsey R Mayo Stephen Mockrin Lucila Ohno-Machado Sheri D Schully Andrea H Ramirez Philip Greenland |
| author_facet | Alvaro Alonso Aniqa B Alam Hooman Kamel Vignesh Subbian Jun Qian Eric Boerwinkle Mine Cicek Cheryl R Clark Elizabeth G Cohn Kelly A Gebo Roxana Loperena-Cortes Kelsey R Mayo Stephen Mockrin Lucila Ohno-Machado Sheri D Schully Andrea H Ramirez Philip Greenland |
| author_sort | Alvaro Alonso |
| collection | DOAJ |
| description | <h4>Background</h4>The prevalence, incidence and risk factors of atrial fibrillation (AF) in a large, geographically and ethnically diverse cohort in the United States have not been fully described.<h4>Methods</h4>We analyzed data from 173,099 participants of the All of Us Research Program recruited in the period 2017-2019, with 92,318 of them having electronic health records (EHR) data available, and 35,483 having completed a medical history survey. Presence of AF at baseline was identified from self-report and EHR records. Incident AF was obtained from EHR. Demographic, anthropometric and clinical risk factors were obtained from questionnaires, baseline physical measurements and EHR.<h4>Results</h4>At enrollment, mean age was 52 years old (range 18-89). Females and males accounted for 61% and 39% respectively. Non-Hispanic Whites accounted for 67% of participants, with non-Hispanic Blacks, non-Hispanic Asians and Hispanics accounting for 26%, 4% and 3% of participants, respectively. Among 92,318 participants with available EHR data, 3,885 (4.2%) had AF at the time of study enrollment, while the corresponding figure among 35,483 with medical history data was 2,084 (5.9%). During a median follow-up of 16 months, 354 new cases of AF were identified among 88,433 eligible participants. Individuals who were older, male, non-Hispanic white, had higher body mass index, or a prior history of heart failure or coronary heart disease had higher prevalence and incidence of AF.<h4>Conclusion</h4>The epidemiology of AF in the All of Us Research Program is similar to that reported in smaller studies with careful phenotyping, highlighting the value of this new resource for the study of AF and, potentially, other cardiovascular diseases. |
| format | Article |
| id | doaj-art-34dc16aa9abc4e22b263342870af384e |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-34dc16aa9abc4e22b263342870af384e2025-08-20T02:33:19ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01173e026549810.1371/journal.pone.0265498Epidemiology of atrial fibrillation in the All of Us Research Program.Alvaro AlonsoAniqa B AlamHooman KamelVignesh SubbianJun QianEric BoerwinkleMine CicekCheryl R ClarkElizabeth G CohnKelly A GeboRoxana Loperena-CortesKelsey R MayoStephen MockrinLucila Ohno-MachadoSheri D SchullyAndrea H RamirezPhilip Greenland<h4>Background</h4>The prevalence, incidence and risk factors of atrial fibrillation (AF) in a large, geographically and ethnically diverse cohort in the United States have not been fully described.<h4>Methods</h4>We analyzed data from 173,099 participants of the All of Us Research Program recruited in the period 2017-2019, with 92,318 of them having electronic health records (EHR) data available, and 35,483 having completed a medical history survey. Presence of AF at baseline was identified from self-report and EHR records. Incident AF was obtained from EHR. Demographic, anthropometric and clinical risk factors were obtained from questionnaires, baseline physical measurements and EHR.<h4>Results</h4>At enrollment, mean age was 52 years old (range 18-89). Females and males accounted for 61% and 39% respectively. Non-Hispanic Whites accounted for 67% of participants, with non-Hispanic Blacks, non-Hispanic Asians and Hispanics accounting for 26%, 4% and 3% of participants, respectively. Among 92,318 participants with available EHR data, 3,885 (4.2%) had AF at the time of study enrollment, while the corresponding figure among 35,483 with medical history data was 2,084 (5.9%). During a median follow-up of 16 months, 354 new cases of AF were identified among 88,433 eligible participants. Individuals who were older, male, non-Hispanic white, had higher body mass index, or a prior history of heart failure or coronary heart disease had higher prevalence and incidence of AF.<h4>Conclusion</h4>The epidemiology of AF in the All of Us Research Program is similar to that reported in smaller studies with careful phenotyping, highlighting the value of this new resource for the study of AF and, potentially, other cardiovascular diseases.https://doi.org/10.1371/journal.pone.0265498 |
| spellingShingle | Alvaro Alonso Aniqa B Alam Hooman Kamel Vignesh Subbian Jun Qian Eric Boerwinkle Mine Cicek Cheryl R Clark Elizabeth G Cohn Kelly A Gebo Roxana Loperena-Cortes Kelsey R Mayo Stephen Mockrin Lucila Ohno-Machado Sheri D Schully Andrea H Ramirez Philip Greenland Epidemiology of atrial fibrillation in the All of Us Research Program. PLoS ONE |
| title | Epidemiology of atrial fibrillation in the All of Us Research Program. |
| title_full | Epidemiology of atrial fibrillation in the All of Us Research Program. |
| title_fullStr | Epidemiology of atrial fibrillation in the All of Us Research Program. |
| title_full_unstemmed | Epidemiology of atrial fibrillation in the All of Us Research Program. |
| title_short | Epidemiology of atrial fibrillation in the All of Us Research Program. |
| title_sort | epidemiology of atrial fibrillation in the all of us research program |
| url | https://doi.org/10.1371/journal.pone.0265498 |
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