Management of Pruritus in Chronic Liver Disease
Background. There continues to be uncertainty on the ideal treatment of pruritus in chronic liver disease. The aim of this study was to gather the latest information on the evidence-based management of pruritus in chronic liver disease. Methodology. A literature search for pruritus in chronic liver...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2015/295891 |
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| _version_ | 1849306420612169728 |
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| author | Angeline Bhalerao Gurdeep S. Mannu |
| author_facet | Angeline Bhalerao Gurdeep S. Mannu |
| author_sort | Angeline Bhalerao |
| collection | DOAJ |
| description | Background. There continues to be uncertainty on the ideal treatment of pruritus in chronic liver disease. The aim of this study was to gather the latest information on the evidence-based management of pruritus in chronic liver disease. Methodology. A literature search for pruritus in chronic liver disease was conducted using Pubmed and Embase database systems using the MeSH terms “pruritus,” “chronic liver disease,” “cholestatic liver disease,” and “treatment.” Results. The current understanding of the pathophysiology of pruritus is described in addition to detailing research into contemporary treatment options of the condition. These medical treatments range from bile salts, rifampicin, and opioid receptor antagonists to antihistamines. Conclusion. The burden of pruritus in liver disease patients persists and, although it is a common symptom, it can be difficult to manage. In recent years there has been greater study into the etiology and treatment of the condition. Nonetheless, pruritus remains poorly understood and many patients continue to suffer, reiterating the need for further research to improve our understanding of the etiology and treatment for the condition. |
| format | Article |
| id | doaj-art-34d3f634d81c469fb69efffa2b4e9e02 |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-34d3f634d81c469fb69efffa2b4e9e022025-08-20T03:55:06ZengWileyDermatology Research and Practice1687-61051687-61132015-01-01201510.1155/2015/295891295891Management of Pruritus in Chronic Liver DiseaseAngeline Bhalerao0Gurdeep S. Mannu1General Practice, Ipswich, Suffolk IP4 5PD, UKOxford University Hospitals, Oxford OX3 9DU, UKBackground. There continues to be uncertainty on the ideal treatment of pruritus in chronic liver disease. The aim of this study was to gather the latest information on the evidence-based management of pruritus in chronic liver disease. Methodology. A literature search for pruritus in chronic liver disease was conducted using Pubmed and Embase database systems using the MeSH terms “pruritus,” “chronic liver disease,” “cholestatic liver disease,” and “treatment.” Results. The current understanding of the pathophysiology of pruritus is described in addition to detailing research into contemporary treatment options of the condition. These medical treatments range from bile salts, rifampicin, and opioid receptor antagonists to antihistamines. Conclusion. The burden of pruritus in liver disease patients persists and, although it is a common symptom, it can be difficult to manage. In recent years there has been greater study into the etiology and treatment of the condition. Nonetheless, pruritus remains poorly understood and many patients continue to suffer, reiterating the need for further research to improve our understanding of the etiology and treatment for the condition.http://dx.doi.org/10.1155/2015/295891 |
| spellingShingle | Angeline Bhalerao Gurdeep S. Mannu Management of Pruritus in Chronic Liver Disease Dermatology Research and Practice |
| title | Management of Pruritus in Chronic Liver Disease |
| title_full | Management of Pruritus in Chronic Liver Disease |
| title_fullStr | Management of Pruritus in Chronic Liver Disease |
| title_full_unstemmed | Management of Pruritus in Chronic Liver Disease |
| title_short | Management of Pruritus in Chronic Liver Disease |
| title_sort | management of pruritus in chronic liver disease |
| url | http://dx.doi.org/10.1155/2015/295891 |
| work_keys_str_mv | AT angelinebhalerao managementofpruritusinchronicliverdisease AT gurdeepsmannu managementofpruritusinchronicliverdisease |