Mitochondrial calcium transport during autophagy initiation
While it has been shown that Ca2+ dynamics at the ER membrane is essential for the initiation of certain types of autophagy such as starvation-induced autophagy, how mitochondrial Ca2+ transport changes during the first stage of autophagy is not systemically characterized. An investigation of mitoch...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-01-01
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| Series: | Mitochondrial Communications |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590279224000026 |
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| author | Sujyoti Chandra Parul Katiyar Aarooran S. Durairaj Xinnan Wang |
| author_facet | Sujyoti Chandra Parul Katiyar Aarooran S. Durairaj Xinnan Wang |
| author_sort | Sujyoti Chandra |
| collection | DOAJ |
| description | While it has been shown that Ca2+ dynamics at the ER membrane is essential for the initiation of certain types of autophagy such as starvation-induced autophagy, how mitochondrial Ca2+ transport changes during the first stage of autophagy is not systemically characterized. An investigation of mitochondrial Ca2+ dynamics during autophagy initiation may help us determine the relationship between autophagy and mitochondrial Ca2+ fluxes. Here we examine acute mitochondrial and ER calcium responses to a panel of autophagy inducers in different cell types. Mitochondrial Ca2+ transport and Ca2+ transients at the ER membrane are triggered by different autophagy inducers. The mitophagy-inducer-initiated mitochondrial Ca2+ uptake relies on mitochondrial calcium uniporter and may decelerate the following mitophagy. In neurons derived from a Parkinson's patient, mitophagy-inducer-triggered mitochondrial Ca2+ influx is faster, which may slow the ensuing mitophagy. |
| format | Article |
| id | doaj-art-34d2031a4bac46d382c5f0fd4302520e |
| institution | DOAJ |
| issn | 2590-2792 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Mitochondrial Communications |
| spelling | doaj-art-34d2031a4bac46d382c5f0fd4302520e2025-08-20T02:46:39ZengKeAi Communications Co., Ltd.Mitochondrial Communications2590-27922024-01-012142010.1016/j.mitoco.2024.01.002Mitochondrial calcium transport during autophagy initiationSujyoti Chandra0Parul Katiyar1Aarooran S. Durairaj2Xinnan Wang3Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA94305, USADepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA94305, USADepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA94305, USACorresponding author.; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA94305, USAWhile it has been shown that Ca2+ dynamics at the ER membrane is essential for the initiation of certain types of autophagy such as starvation-induced autophagy, how mitochondrial Ca2+ transport changes during the first stage of autophagy is not systemically characterized. An investigation of mitochondrial Ca2+ dynamics during autophagy initiation may help us determine the relationship between autophagy and mitochondrial Ca2+ fluxes. Here we examine acute mitochondrial and ER calcium responses to a panel of autophagy inducers in different cell types. Mitochondrial Ca2+ transport and Ca2+ transients at the ER membrane are triggered by different autophagy inducers. The mitophagy-inducer-initiated mitochondrial Ca2+ uptake relies on mitochondrial calcium uniporter and may decelerate the following mitophagy. In neurons derived from a Parkinson's patient, mitophagy-inducer-triggered mitochondrial Ca2+ influx is faster, which may slow the ensuing mitophagy.http://www.sciencedirect.com/science/article/pii/S2590279224000026Mitochondrial Ca2+ uptakeMitophagyAutophagyER Ca2+ transientParkinsonMCU |
| spellingShingle | Sujyoti Chandra Parul Katiyar Aarooran S. Durairaj Xinnan Wang Mitochondrial calcium transport during autophagy initiation Mitochondrial Communications Mitochondrial Ca2+ uptake Mitophagy Autophagy ER Ca2+ transient Parkinson MCU |
| title | Mitochondrial calcium transport during autophagy initiation |
| title_full | Mitochondrial calcium transport during autophagy initiation |
| title_fullStr | Mitochondrial calcium transport during autophagy initiation |
| title_full_unstemmed | Mitochondrial calcium transport during autophagy initiation |
| title_short | Mitochondrial calcium transport during autophagy initiation |
| title_sort | mitochondrial calcium transport during autophagy initiation |
| topic | Mitochondrial Ca2+ uptake Mitophagy Autophagy ER Ca2+ transient Parkinson MCU |
| url | http://www.sciencedirect.com/science/article/pii/S2590279224000026 |
| work_keys_str_mv | AT sujyotichandra mitochondrialcalciumtransportduringautophagyinitiation AT parulkatiyar mitochondrialcalciumtransportduringautophagyinitiation AT aarooransdurairaj mitochondrialcalciumtransportduringautophagyinitiation AT xinnanwang mitochondrialcalciumtransportduringautophagyinitiation |