Epstein–Barr virus-associated inflammatory pseudotumor variant of follicular dendritic cell sarcoma of the liver: a case report and review of the literature
Abstract Background Follicular dendritic cell sarcoma is a rare stromal tumor with no standard treatment. However, some reports have revealed that follicular dendritic cell sarcoma has an inflammatory pseudotumor variant associated with Epstein–Barr virus infection that has a relatively good prognos...
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| Language: | English |
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Japan Surgical Society
2022-12-01
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| Series: | Surgical Case Reports |
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| Online Access: | https://doi.org/10.1186/s40792-022-01572-w |
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| author | K. Abe M. Kitago S. Matsuda M. Shinoda H. Yagi Y. Abe G. Oshima S. Hori Y. Endo T. Yokose E. Miura N. Kubota A. Ueno Y. Masugi H. Ojima M. Sakamoto Y. Kitagawa |
| author_facet | K. Abe M. Kitago S. Matsuda M. Shinoda H. Yagi Y. Abe G. Oshima S. Hori Y. Endo T. Yokose E. Miura N. Kubota A. Ueno Y. Masugi H. Ojima M. Sakamoto Y. Kitagawa |
| author_sort | K. Abe |
| collection | DOAJ |
| description | Abstract Background Follicular dendritic cell sarcoma is a rare stromal tumor with no standard treatment. However, some reports have revealed that follicular dendritic cell sarcoma has an inflammatory pseudotumor variant associated with Epstein–Barr virus infection that has a relatively good prognosis. In this report, we present a case of a resected inflammatory pseudotumor variant of follicular dendritic cell sarcoma of the liver, and have reviewed the literature on the clinicopathological, molecular, and genomic features of this tumor. Case presentation The inflammatory pseudotumor variant of follicular dendritic cell sarcoma originates only in the liver or spleen, causes no symptoms, and is more common in middle-aged Asian women. It has no characteristic imaging features, which partially explains why the inflammatory pseudotumor variant of follicular dendritic cell sarcoma is difficult to diagnose. Pathologically, the inflammatory pseudotumor variant of follicular dendritic cell sarcoma has spindle cells mixed with inflammatory cells and is variably positive for follicular dendritic cell markers (CD21, CD23, and CD35) and Epstein–Barr virus-encoded RNA. On genetic analysis, patients with this tumor high levels of latent membrane protein 1 gene expression and extremely low levels of host C–X–C Chemokine Receptor type 7 gene expression, indicating that the inflammatory pseudotumor variant of follicular dendritic cell sarcoma has a latent Epstein–Barr virus type 2 infection. Conclusions The inflammatory pseudotumor variant of follicular dendritic cell sarcoma is an Epstein–Barr virus-associated tumor and a favorable prognosis by surgical resection, similar to Epstein–Barr virus-associated gastric cancer. |
| format | Article |
| id | doaj-art-34d08cbb59984effaa1d26baafc5b732 |
| institution | Kabale University |
| issn | 2198-7793 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Japan Surgical Society |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj-art-34d08cbb59984effaa1d26baafc5b7322025-08-20T03:28:29ZengJapan Surgical SocietySurgical Case Reports2198-77932022-12-018111010.1186/s40792-022-01572-wEpstein–Barr virus-associated inflammatory pseudotumor variant of follicular dendritic cell sarcoma of the liver: a case report and review of the literatureK. Abe0M. Kitago1S. Matsuda2M. Shinoda3H. Yagi4Y. Abe5G. Oshima6S. Hori7Y. Endo8T. Yokose9E. Miura10N. Kubota11A. Ueno12Y. Masugi13H. Ojima14M. Sakamoto15Y. Kitagawa16Department of Surgery, Keio University School of MedicineDepartment of Surgery, Keio University School of MedicineDepartment of Surgery, Keio University School of MedicineDepartment of Surgery, Keio University School of MedicineDepartment of Surgery, Keio University School of MedicineDepartment of Surgery, Keio University School of MedicineDepartment of Surgery, Keio University School of MedicineDepartment of Surgery, Keio University School of MedicineDepartment of Surgery, Keio University School of MedicineDepartment of Surgery, Keio University School of MedicineDepartment of Pathology, Keio University School of MedicineDepartment of Pathology, Keio University School of MedicineDepartment of Pathology, Keio University School of MedicineDepartment of Pathology, Keio University School of MedicineDepartment of Pathology, Keio University School of MedicineDepartment of Pathology, Keio University School of MedicineDepartment of Surgery, Keio University School of MedicineAbstract Background Follicular dendritic cell sarcoma is a rare stromal tumor with no standard treatment. However, some reports have revealed that follicular dendritic cell sarcoma has an inflammatory pseudotumor variant associated with Epstein–Barr virus infection that has a relatively good prognosis. In this report, we present a case of a resected inflammatory pseudotumor variant of follicular dendritic cell sarcoma of the liver, and have reviewed the literature on the clinicopathological, molecular, and genomic features of this tumor. Case presentation The inflammatory pseudotumor variant of follicular dendritic cell sarcoma originates only in the liver or spleen, causes no symptoms, and is more common in middle-aged Asian women. It has no characteristic imaging features, which partially explains why the inflammatory pseudotumor variant of follicular dendritic cell sarcoma is difficult to diagnose. Pathologically, the inflammatory pseudotumor variant of follicular dendritic cell sarcoma has spindle cells mixed with inflammatory cells and is variably positive for follicular dendritic cell markers (CD21, CD23, and CD35) and Epstein–Barr virus-encoded RNA. On genetic analysis, patients with this tumor high levels of latent membrane protein 1 gene expression and extremely low levels of host C–X–C Chemokine Receptor type 7 gene expression, indicating that the inflammatory pseudotumor variant of follicular dendritic cell sarcoma has a latent Epstein–Barr virus type 2 infection. Conclusions The inflammatory pseudotumor variant of follicular dendritic cell sarcoma is an Epstein–Barr virus-associated tumor and a favorable prognosis by surgical resection, similar to Epstein–Barr virus-associated gastric cancer.https://doi.org/10.1186/s40792-022-01572-wFollicular dendritic cell sarcomaInflammatory pseudotumor variantEpstein–Barr virus-associated tumorClinicopathological featuresMolecular mechanismsLaparoscopic surgery |
| spellingShingle | K. Abe M. Kitago S. Matsuda M. Shinoda H. Yagi Y. Abe G. Oshima S. Hori Y. Endo T. Yokose E. Miura N. Kubota A. Ueno Y. Masugi H. Ojima M. Sakamoto Y. Kitagawa Epstein–Barr virus-associated inflammatory pseudotumor variant of follicular dendritic cell sarcoma of the liver: a case report and review of the literature Surgical Case Reports Follicular dendritic cell sarcoma Inflammatory pseudotumor variant Epstein–Barr virus-associated tumor Clinicopathological features Molecular mechanisms Laparoscopic surgery |
| title | Epstein–Barr virus-associated inflammatory pseudotumor variant of follicular dendritic cell sarcoma of the liver: a case report and review of the literature |
| title_full | Epstein–Barr virus-associated inflammatory pseudotumor variant of follicular dendritic cell sarcoma of the liver: a case report and review of the literature |
| title_fullStr | Epstein–Barr virus-associated inflammatory pseudotumor variant of follicular dendritic cell sarcoma of the liver: a case report and review of the literature |
| title_full_unstemmed | Epstein–Barr virus-associated inflammatory pseudotumor variant of follicular dendritic cell sarcoma of the liver: a case report and review of the literature |
| title_short | Epstein–Barr virus-associated inflammatory pseudotumor variant of follicular dendritic cell sarcoma of the liver: a case report and review of the literature |
| title_sort | epstein barr virus associated inflammatory pseudotumor variant of follicular dendritic cell sarcoma of the liver a case report and review of the literature |
| topic | Follicular dendritic cell sarcoma Inflammatory pseudotumor variant Epstein–Barr virus-associated tumor Clinicopathological features Molecular mechanisms Laparoscopic surgery |
| url | https://doi.org/10.1186/s40792-022-01572-w |
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