Very Severe and Refractory Noninfectious Cystitis in Patients with Systemic Lupus Erythematosus: Potential Role of Rituximab Therapy
Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease with various clinical manifestations, including, rarely, a form of interstitial cystitis (lupus cystitis, LC). LC can be asymptomatic and usually has discrete symptoms that improve with conventional therapies available f...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2021/6610111 |
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| author | Vanessa Ocampo-Piraquive Inés Mondragón-Lenis Juan G. De los Rios Carlos A. Cañas |
| author_facet | Vanessa Ocampo-Piraquive Inés Mondragón-Lenis Juan G. De los Rios Carlos A. Cañas |
| author_sort | Vanessa Ocampo-Piraquive |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease with various clinical manifestations, including, rarely, a form of interstitial cystitis (lupus cystitis, LC). LC can be asymptomatic and usually has discrete symptoms that improve with conventional therapies available for SLE and/or typical interstitial cystitis. A very severe and refractory form is rarely described. In this study, we present four patients with SLE and a very severe form of noninfectious cystitis refractory to the different forms of treatment described. The clinical descriptions of the cases, demographic factors, manifestations associated with SLE, and clinical and paraclinical manifestations related to cystitis, treatments, and outcomes are provided. A proposal for the pathogenesis of this condition is based on the common findings of these patients, including the fact that three were in SLE remission and all four receiving rituximab as induction and/or maintenance therapy. |
| format | Article |
| id | doaj-art-34cfe5852d16484ca7a11293f11eab36 |
| institution | Kabale University |
| issn | 2090-6889 2090-6897 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-34cfe5852d16484ca7a11293f11eab362025-08-20T03:55:06ZengWileyCase Reports in Rheumatology2090-68892090-68972021-01-01202110.1155/2021/66101116610111Very Severe and Refractory Noninfectious Cystitis in Patients with Systemic Lupus Erythematosus: Potential Role of Rituximab TherapyVanessa Ocampo-Piraquive0Inés Mondragón-Lenis1Juan G. De los Rios2Carlos A. Cañas3Unit of Rheumatology, Fundación Valle Del Lili, Universidad Icesi, Cali, ColombiaDepartment of Internal Medicine, Fundación Valle Del Lili, Universidad Icesi, Cali, ColombiaDepartment of Urology, Fundación Valle Del Lili, Universidad Icesi, Cali, ColombiaUnit of Rheumatology, Fundación Valle Del Lili, Universidad Icesi, Cali, ColombiaSystemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease with various clinical manifestations, including, rarely, a form of interstitial cystitis (lupus cystitis, LC). LC can be asymptomatic and usually has discrete symptoms that improve with conventional therapies available for SLE and/or typical interstitial cystitis. A very severe and refractory form is rarely described. In this study, we present four patients with SLE and a very severe form of noninfectious cystitis refractory to the different forms of treatment described. The clinical descriptions of the cases, demographic factors, manifestations associated with SLE, and clinical and paraclinical manifestations related to cystitis, treatments, and outcomes are provided. A proposal for the pathogenesis of this condition is based on the common findings of these patients, including the fact that three were in SLE remission and all four receiving rituximab as induction and/or maintenance therapy.http://dx.doi.org/10.1155/2021/6610111 |
| spellingShingle | Vanessa Ocampo-Piraquive Inés Mondragón-Lenis Juan G. De los Rios Carlos A. Cañas Very Severe and Refractory Noninfectious Cystitis in Patients with Systemic Lupus Erythematosus: Potential Role of Rituximab Therapy Case Reports in Rheumatology |
| title | Very Severe and Refractory Noninfectious Cystitis in Patients with Systemic Lupus Erythematosus: Potential Role of Rituximab Therapy |
| title_full | Very Severe and Refractory Noninfectious Cystitis in Patients with Systemic Lupus Erythematosus: Potential Role of Rituximab Therapy |
| title_fullStr | Very Severe and Refractory Noninfectious Cystitis in Patients with Systemic Lupus Erythematosus: Potential Role of Rituximab Therapy |
| title_full_unstemmed | Very Severe and Refractory Noninfectious Cystitis in Patients with Systemic Lupus Erythematosus: Potential Role of Rituximab Therapy |
| title_short | Very Severe and Refractory Noninfectious Cystitis in Patients with Systemic Lupus Erythematosus: Potential Role of Rituximab Therapy |
| title_sort | very severe and refractory noninfectious cystitis in patients with systemic lupus erythematosus potential role of rituximab therapy |
| url | http://dx.doi.org/10.1155/2021/6610111 |
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