Assessment of the Nutritional Status, Bone Mineralization, and Anthropometrics of Children with Thalassemia Major
Objective: Children with thalassemia major (TM) are prone to growth failure and micronutrient deficiency. Thus, this study aimed to evaluate nutritional status, anthropometrics, and bone mineralization defects in patients with regular blood transfusion. Methods: Data obtained were analyzed by evalu...
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Galenos Publishing House
2021-12-01
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| Series: | Medeniyet Medical Journal |
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| Online Access: | https://medeniyetmedicaljournal.org/jvi.aspx?pdir=medeniyet&plng=eng&un=MEDJ-66915&look4= |
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| author | Serap Cevher Bulğurcu Aylin Canbolat Ayhan Hamdi Cihan Emeksiz Fahri Ovalı |
| author_facet | Serap Cevher Bulğurcu Aylin Canbolat Ayhan Hamdi Cihan Emeksiz Fahri Ovalı |
| author_sort | Serap Cevher Bulğurcu |
| collection | DOAJ |
| description | Objective: Children with thalassemia major (TM) are prone to growth failure and micronutrient deficiency. Thus, this study aimed to evaluate nutritional status, anthropometrics, and bone mineralization defects in patients with regular blood transfusion.
Methods: Data obtained were analyzed by evaluating laboratory tests, anthropometric measures, and bone mineral density.
Results: This study included 29 patients (62% male and 38% female) with a mean age of 12.26±4.74 years, mean pre-transfusion hemoglobin of 8.64±1.01 g/dL, and mean serum ferritin of 1158.6±556.8 ng/ mL. Vitamin D (72.4%), selenium (72.4%), and folate (37.9%) deficiencies were most frequent. Hypocalcemia was observed in 17.2%, hypomagnesemia in 3.5%, and decreased ceruloplasmin in 10.3% of patients. Folate was higher between 2 and 6 years old (p=0.028). Ceruloplasmin was higher between 6 and 10 years old (p=0.018). Selenium was significantly higher in patients with a ferritin of ≥1,500 (p=0.008). No significant ferritin-related differences were found in other micronutrients (p>0.05). Body mass index (BMI) were <5 percentile (p) in 31% of patient, whereas none was >95 p. Height in 24.5% and weight in 20.7% of patients were <3 p, whereas none with >97 p. BMI of patients aged 10-18 years was significantly higher (p=0.001). Anthropometric percentiles did not significantly differ in the mean serum ferritin and micronutrient levels. Hypoparathyroidism was observed in 13.8% and hypothyroidism in 3.5% of patients. Low bone density was detected in 14.8% (2 osteopenic and 2 osteoporotic) of patients. Bone mineral density did not significantly differ in the ferritin and micronutrient levels.
Conclusions: Nutritional support and deficiency prevention are important to minimize the burden of complications and increase the life expectancy and quality in patients with TM. |
| format | Article |
| id | doaj-art-34c09a597e674e01be842e779ab35b6d |
| institution | Kabale University |
| issn | 2149-2042 2149-4606 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Medeniyet Medical Journal |
| spelling | doaj-art-34c09a597e674e01be842e779ab35b6d2025-02-03T08:56:15ZengGalenos Publishing HouseMedeniyet Medical Journal2149-20422149-46062021-12-0136432533210.4274/MMJ.galenos.2021.66915Assessment of the Nutritional Status, Bone Mineralization, and Anthropometrics of Children with Thalassemia MajorSerap Cevher Bulğurcu0https://orcid.org/0000-0002-4910-6610Aylin Canbolat Ayhan1https://orcid.org/0000-0001-6173-2350Hamdi Cihan Emeksiz2https://orcid.org/0000-0002-4815-1591Fahri Ovalı3https://orcid.org/0000-0002-9717-313XIstanbul Medeniyet University Faculty of Medicine, Department of Pediatrics, Istanbul, TurkeyIstanbul Medeniyet University Faculty of Medicine, Department of Pediatric Hematology-Oncology, Istanbul, TurkeyIstanbul Medeniyet University Faculty of Medicine, Department of Pediatric Endocrinology, Istanbul, TurkeyIstanbul Medeniyet University Faculty of Medicine, Department of Pediatrics, Istanbul, TurkeyObjective: Children with thalassemia major (TM) are prone to growth failure and micronutrient deficiency. Thus, this study aimed to evaluate nutritional status, anthropometrics, and bone mineralization defects in patients with regular blood transfusion. Methods: Data obtained were analyzed by evaluating laboratory tests, anthropometric measures, and bone mineral density. Results: This study included 29 patients (62% male and 38% female) with a mean age of 12.26±4.74 years, mean pre-transfusion hemoglobin of 8.64±1.01 g/dL, and mean serum ferritin of 1158.6±556.8 ng/ mL. Vitamin D (72.4%), selenium (72.4%), and folate (37.9%) deficiencies were most frequent. Hypocalcemia was observed in 17.2%, hypomagnesemia in 3.5%, and decreased ceruloplasmin in 10.3% of patients. Folate was higher between 2 and 6 years old (p=0.028). Ceruloplasmin was higher between 6 and 10 years old (p=0.018). Selenium was significantly higher in patients with a ferritin of ≥1,500 (p=0.008). No significant ferritin-related differences were found in other micronutrients (p>0.05). Body mass index (BMI) were <5 percentile (p) in 31% of patient, whereas none was >95 p. Height in 24.5% and weight in 20.7% of patients were <3 p, whereas none with >97 p. BMI of patients aged 10-18 years was significantly higher (p=0.001). Anthropometric percentiles did not significantly differ in the mean serum ferritin and micronutrient levels. Hypoparathyroidism was observed in 13.8% and hypothyroidism in 3.5% of patients. Low bone density was detected in 14.8% (2 osteopenic and 2 osteoporotic) of patients. Bone mineral density did not significantly differ in the ferritin and micronutrient levels. Conclusions: Nutritional support and deficiency prevention are important to minimize the burden of complications and increase the life expectancy and quality in patients with TM.https://medeniyetmedicaljournal.org/jvi.aspx?pdir=medeniyet&plng=eng&un=MEDJ-66915&look4=thalassemiamicronutrientanthropometricosteopeniabody mass index |
| spellingShingle | Serap Cevher Bulğurcu Aylin Canbolat Ayhan Hamdi Cihan Emeksiz Fahri Ovalı Assessment of the Nutritional Status, Bone Mineralization, and Anthropometrics of Children with Thalassemia Major Medeniyet Medical Journal thalassemia micronutrient anthropometric osteopenia body mass index |
| title | Assessment of the Nutritional Status, Bone Mineralization, and Anthropometrics of Children with Thalassemia Major |
| title_full | Assessment of the Nutritional Status, Bone Mineralization, and Anthropometrics of Children with Thalassemia Major |
| title_fullStr | Assessment of the Nutritional Status, Bone Mineralization, and Anthropometrics of Children with Thalassemia Major |
| title_full_unstemmed | Assessment of the Nutritional Status, Bone Mineralization, and Anthropometrics of Children with Thalassemia Major |
| title_short | Assessment of the Nutritional Status, Bone Mineralization, and Anthropometrics of Children with Thalassemia Major |
| title_sort | assessment of the nutritional status bone mineralization and anthropometrics of children with thalassemia major |
| topic | thalassemia micronutrient anthropometric osteopenia body mass index |
| url | https://medeniyetmedicaljournal.org/jvi.aspx?pdir=medeniyet&plng=eng&un=MEDJ-66915&look4= |
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