Hypoglycemia and the risk of cognitive impairment and dementia in elderly and senile patients with type 2 diabetes
Research results show that poor glycemic control and recurrent episodes of severe hypoglycaemia are associated with a decrease in cognitive function in elderly people with type 2 diabetes mellitus (T2DM). On the other hand, patients with diabetes mellitus associated with cognitive impairment/dementi...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Endocrinology Research Centre
2020-04-01
|
| Series: | Сахарный диабет |
| Subjects: | |
| Online Access: | https://www.dia-endojournals.ru/jour/article/view/10202 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850254448457154560 |
|---|---|
| author | Olga D. Ostroumova Elena V. Surkova Irina V. Goloborodova Antonina V. Starodubova Alexey I. Kochetkov Tamara D. Kiknadze Gagik R. Galstyan |
| author_facet | Olga D. Ostroumova Elena V. Surkova Irina V. Goloborodova Antonina V. Starodubova Alexey I. Kochetkov Tamara D. Kiknadze Gagik R. Galstyan |
| author_sort | Olga D. Ostroumova |
| collection | DOAJ |
| description | Research results show that poor glycemic control and recurrent episodes of severe hypoglycaemia are associated with a decrease in cognitive function in elderly people with type 2 diabetes mellitus (T2DM). On the other hand, patients with diabetes mellitus associated with cognitive impairment/dementia are most at risk of developing hypoglycaemic conditions. It is obvious that the relationship between hypoglycaemia and dementia is very complex and has a mutually aggravating nature. Studies also show that individuals of older age groups with diabetes and cognitive impairment have a high risk of developing hypoglycaemic conditions, such as unwanted side effects from glucose-lowering therapy. In this case, of particular interest is the question that is being actively studied at the present time, which is concerning the effect of different groups of glucose-lowering antidiabetic drugs on the cognitive status and the rate of cognitive decline in diabetic patients with cognitive impairment. In this review, we attempted to summarise, systematise, and present data available in the literature concerning the effect of hypoglycaemia on the risk of cognitive impairment and dementia in elderly and senile patients with type-2 diabetes, as well as the degree of participation in this process of of various groups of sugar-lowering antidiabetic drugs. |
| format | Article |
| id | doaj-art-34b4b191a1704fb8b99d7c5aae6cc87f |
| institution | OA Journals |
| issn | 2072-0351 2072-0378 |
| language | English |
| publishDate | 2020-04-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj-art-34b4b191a1704fb8b99d7c5aae6cc87f2025-08-20T01:57:08ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782020-04-01231728710.14341/DM1020210595Hypoglycemia and the risk of cognitive impairment and dementia in elderly and senile patients with type 2 diabetesOlga D. Ostroumova0Elena V. Surkova1Irina V. Goloborodova2Antonina V. Starodubova3Alexey I. Kochetkov4Tamara D. Kiknadze5Gagik R. Galstyan6A.I. Evdokimov Moscow State Medical-Stomatological University; I.M. Sechenov Sechenov First Moscow State Medical UniversityEndocrinology Research CentreA.I. Evdokimov Moscow State Medical-Stomatological UniversityFederal Research Centre of Nutrition, Biotechnology and Food Safety; N.I. Pirogov Russian National Research Medical UniversityN.I. Pirogov Russian National Research Medical University; Russian Clinical and Research Center of GerontologyFederal Research Centre of Nutrition, Biotechnology and Food SafetyEndocrinology Research CentreResearch results show that poor glycemic control and recurrent episodes of severe hypoglycaemia are associated with a decrease in cognitive function in elderly people with type 2 diabetes mellitus (T2DM). On the other hand, patients with diabetes mellitus associated with cognitive impairment/dementia are most at risk of developing hypoglycaemic conditions. It is obvious that the relationship between hypoglycaemia and dementia is very complex and has a mutually aggravating nature. Studies also show that individuals of older age groups with diabetes and cognitive impairment have a high risk of developing hypoglycaemic conditions, such as unwanted side effects from glucose-lowering therapy. In this case, of particular interest is the question that is being actively studied at the present time, which is concerning the effect of different groups of glucose-lowering antidiabetic drugs on the cognitive status and the rate of cognitive decline in diabetic patients with cognitive impairment. In this review, we attempted to summarise, systematise, and present data available in the literature concerning the effect of hypoglycaemia on the risk of cognitive impairment and dementia in elderly and senile patients with type-2 diabetes, as well as the degree of participation in this process of of various groups of sugar-lowering antidiabetic drugs.https://www.dia-endojournals.ru/jour/article/view/10202hypoglycemiacognitive impairmentdementiadiabetes mellitusantidiabetic drugs |
| spellingShingle | Olga D. Ostroumova Elena V. Surkova Irina V. Goloborodova Antonina V. Starodubova Alexey I. Kochetkov Tamara D. Kiknadze Gagik R. Galstyan Hypoglycemia and the risk of cognitive impairment and dementia in elderly and senile patients with type 2 diabetes Сахарный диабет hypoglycemia cognitive impairment dementia diabetes mellitus antidiabetic drugs |
| title | Hypoglycemia and the risk of cognitive impairment and dementia in elderly and senile patients with type 2 diabetes |
| title_full | Hypoglycemia and the risk of cognitive impairment and dementia in elderly and senile patients with type 2 diabetes |
| title_fullStr | Hypoglycemia and the risk of cognitive impairment and dementia in elderly and senile patients with type 2 diabetes |
| title_full_unstemmed | Hypoglycemia and the risk of cognitive impairment and dementia in elderly and senile patients with type 2 diabetes |
| title_short | Hypoglycemia and the risk of cognitive impairment and dementia in elderly and senile patients with type 2 diabetes |
| title_sort | hypoglycemia and the risk of cognitive impairment and dementia in elderly and senile patients with type 2 diabetes |
| topic | hypoglycemia cognitive impairment dementia diabetes mellitus antidiabetic drugs |
| url | https://www.dia-endojournals.ru/jour/article/view/10202 |
| work_keys_str_mv | AT olgadostroumova hypoglycemiaandtheriskofcognitiveimpairmentanddementiainelderlyandsenilepatientswithtype2diabetes AT elenavsurkova hypoglycemiaandtheriskofcognitiveimpairmentanddementiainelderlyandsenilepatientswithtype2diabetes AT irinavgoloborodova hypoglycemiaandtheriskofcognitiveimpairmentanddementiainelderlyandsenilepatientswithtype2diabetes AT antoninavstarodubova hypoglycemiaandtheriskofcognitiveimpairmentanddementiainelderlyandsenilepatientswithtype2diabetes AT alexeyikochetkov hypoglycemiaandtheriskofcognitiveimpairmentanddementiainelderlyandsenilepatientswithtype2diabetes AT tamaradkiknadze hypoglycemiaandtheriskofcognitiveimpairmentanddementiainelderlyandsenilepatientswithtype2diabetes AT gagikrgalstyan hypoglycemiaandtheriskofcognitiveimpairmentanddementiainelderlyandsenilepatientswithtype2diabetes |