Challenges and Innovative Strategies in 3D Printing of Natural Biomolecular Hydrogels
ABSTRACT Natural biomolecules with excellent biocompatibility, degradability, and the ability to guide effective tissue regeneration are considered ideal materials for constructing tissue engineering hydrogel scaffolds. The employing of 3D printing technology facilitates the preparation of natural b...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-06-01
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| Series: | Nano Select |
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| Online Access: | https://doi.org/10.1002/nano.202400149 |
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| author | Jiaqi Qiu Shuo Ma Xue Qu |
| author_facet | Jiaqi Qiu Shuo Ma Xue Qu |
| author_sort | Jiaqi Qiu |
| collection | DOAJ |
| description | ABSTRACT Natural biomolecules with excellent biocompatibility, degradability, and the ability to guide effective tissue regeneration are considered ideal materials for constructing tissue engineering hydrogel scaffolds. The employing of 3D printing technology facilitates the preparation of natural biomolecular‐based scaffold for specific morphological requirements for tissue engineering. However, there are significant limitations in the precise manufacturing of such scaffolds using extrusion‐based 3D printing technology. In this review, we put forward the challenges encountered in the 3D printing process using natural biomolecular inks. Building upon this, we summarize and discuss strategies commonly employed to enhance the printing performance of natural biomolecular inks, including inducing rapid ink cross‐linking, improving ink rheological properties, incorporating auxiliary inks for shaping, flexibly controlling ink extrusion, and optimizing printing equipment. Furthermore, this review offers a perspective on the future design and development of printing technologies based on natural biomolecular inks. |
| format | Article |
| id | doaj-art-34b1955e90cd40a299590b3df9a82f95 |
| institution | Kabale University |
| issn | 2688-4011 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Nano Select |
| spelling | doaj-art-34b1955e90cd40a299590b3df9a82f952025-08-20T03:46:04ZengWiley-VCHNano Select2688-40112025-06-0166n/an/a10.1002/nano.202400149Challenges and Innovative Strategies in 3D Printing of Natural Biomolecular HydrogelsJiaqi Qiu0Shuo Ma1Xue Qu2School of Material Science and Engineering, Key Frontiers Science Center for Materiobiology and Dynamic Chemistry Laboratory for Ultrafine Materials of Ministry of Education East China University of Science and Technology Shanghai P. R. ChinaSchool of Material Science and Engineering, Key Frontiers Science Center for Materiobiology and Dynamic Chemistry Laboratory for Ultrafine Materials of Ministry of Education East China University of Science and Technology Shanghai P. R. ChinaSchool of Material Science and Engineering, Key Frontiers Science Center for Materiobiology and Dynamic Chemistry Laboratory for Ultrafine Materials of Ministry of Education East China University of Science and Technology Shanghai P. R. ChinaABSTRACT Natural biomolecules with excellent biocompatibility, degradability, and the ability to guide effective tissue regeneration are considered ideal materials for constructing tissue engineering hydrogel scaffolds. The employing of 3D printing technology facilitates the preparation of natural biomolecular‐based scaffold for specific morphological requirements for tissue engineering. However, there are significant limitations in the precise manufacturing of such scaffolds using extrusion‐based 3D printing technology. In this review, we put forward the challenges encountered in the 3D printing process using natural biomolecular inks. Building upon this, we summarize and discuss strategies commonly employed to enhance the printing performance of natural biomolecular inks, including inducing rapid ink cross‐linking, improving ink rheological properties, incorporating auxiliary inks for shaping, flexibly controlling ink extrusion, and optimizing printing equipment. Furthermore, this review offers a perspective on the future design and development of printing technologies based on natural biomolecular inks.https://doi.org/10.1002/nano.202400149embedded printingextrusion‐based 3D printingimprove the rheological propertiesnatural biomolecular hydrogel |
| spellingShingle | Jiaqi Qiu Shuo Ma Xue Qu Challenges and Innovative Strategies in 3D Printing of Natural Biomolecular Hydrogels Nano Select embedded printing extrusion‐based 3D printing improve the rheological properties natural biomolecular hydrogel |
| title | Challenges and Innovative Strategies in 3D Printing of Natural Biomolecular Hydrogels |
| title_full | Challenges and Innovative Strategies in 3D Printing of Natural Biomolecular Hydrogels |
| title_fullStr | Challenges and Innovative Strategies in 3D Printing of Natural Biomolecular Hydrogels |
| title_full_unstemmed | Challenges and Innovative Strategies in 3D Printing of Natural Biomolecular Hydrogels |
| title_short | Challenges and Innovative Strategies in 3D Printing of Natural Biomolecular Hydrogels |
| title_sort | challenges and innovative strategies in 3d printing of natural biomolecular hydrogels |
| topic | embedded printing extrusion‐based 3D printing improve the rheological properties natural biomolecular hydrogel |
| url | https://doi.org/10.1002/nano.202400149 |
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