Role of MicroRNA in Governing Synaptic Plasticity
Although synaptic plasticity in neural circuits is orchestrated by an ocean of genes, molecules, and proteins, the underlying mechanisms remain poorly understood. Recently, it is well acknowledged that miRNA exerts widespread regulation over the translation and degradation of target gene in nervous...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/4959523 |
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| _version_ | 1832556055143383040 |
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| author | Yuqin Ye Hongyu Xu Xinhong Su Xiaosheng He |
| author_facet | Yuqin Ye Hongyu Xu Xinhong Su Xiaosheng He |
| author_sort | Yuqin Ye |
| collection | DOAJ |
| description | Although synaptic plasticity in neural circuits is orchestrated by an ocean of genes, molecules, and proteins, the underlying mechanisms remain poorly understood. Recently, it is well acknowledged that miRNA exerts widespread regulation over the translation and degradation of target gene in nervous system. Increasing evidence suggests that quite a few specific miRNAs play important roles in various respects of synaptic plasticity including synaptogenesis, synaptic morphology alteration, and synaptic function modification. More importantly, the miRNA-mediated regulation of synaptic plasticity is not only responsible for synapse development and function but also involved in the pathophysiology of plasticity-related diseases. A review is made here on the function of miRNAs in governing synaptic plasticity, emphasizing the emerging regulatory role of individual miRNAs in synaptic morphological and functional plasticity, as well as their implications in neurological disorders. Understanding of the way in which miRNAs contribute to synaptic plasticity provides rational clues in establishing the novel therapeutic strategy for plasticity-related diseases. |
| format | Article |
| id | doaj-art-34ac9323f4e6497b8cb604a435412c96 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-34ac9323f4e6497b8cb604a435412c962025-02-03T05:46:25ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/49595234959523Role of MicroRNA in Governing Synaptic PlasticityYuqin Ye0Hongyu Xu1Xinhong Su2Xiaosheng He3Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaAlthough synaptic plasticity in neural circuits is orchestrated by an ocean of genes, molecules, and proteins, the underlying mechanisms remain poorly understood. Recently, it is well acknowledged that miRNA exerts widespread regulation over the translation and degradation of target gene in nervous system. Increasing evidence suggests that quite a few specific miRNAs play important roles in various respects of synaptic plasticity including synaptogenesis, synaptic morphology alteration, and synaptic function modification. More importantly, the miRNA-mediated regulation of synaptic plasticity is not only responsible for synapse development and function but also involved in the pathophysiology of plasticity-related diseases. A review is made here on the function of miRNAs in governing synaptic plasticity, emphasizing the emerging regulatory role of individual miRNAs in synaptic morphological and functional plasticity, as well as their implications in neurological disorders. Understanding of the way in which miRNAs contribute to synaptic plasticity provides rational clues in establishing the novel therapeutic strategy for plasticity-related diseases.http://dx.doi.org/10.1155/2016/4959523 |
| spellingShingle | Yuqin Ye Hongyu Xu Xinhong Su Xiaosheng He Role of MicroRNA in Governing Synaptic Plasticity Neural Plasticity |
| title | Role of MicroRNA in Governing Synaptic Plasticity |
| title_full | Role of MicroRNA in Governing Synaptic Plasticity |
| title_fullStr | Role of MicroRNA in Governing Synaptic Plasticity |
| title_full_unstemmed | Role of MicroRNA in Governing Synaptic Plasticity |
| title_short | Role of MicroRNA in Governing Synaptic Plasticity |
| title_sort | role of microrna in governing synaptic plasticity |
| url | http://dx.doi.org/10.1155/2016/4959523 |
| work_keys_str_mv | AT yuqinye roleofmicrornaingoverningsynapticplasticity AT hongyuxu roleofmicrornaingoverningsynapticplasticity AT xinhongsu roleofmicrornaingoverningsynapticplasticity AT xiaoshenghe roleofmicrornaingoverningsynapticplasticity |