Single-cell transcriptome analysis reveals cellular reprogramming and changes of immune cell subsets following tetramethylpyrazine treatment in LPS-induced acute lung injury

Single-cell transcriptome analysis reveals cellular reprogramming and changes of immune cell subsets following tetramethylpyrazine treatment in LPS-induced acute lung injury

Background Acute lung injury (ALI) is a disordered pulmonary disease characterized by acute respiratory insufficiency with tachypnea, cyanosis refractory to oxygen and diffuse alveolar infiltrates. Despite increased research into ALI, current clinical treatments lack effectiveness. Tetramethylpyrazi...

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Bibliographic Details
Main Authors: Mingyan Wu, Shanmei Wang, Xiaolan Chen, Li Shen, Jurong Ding, Hongbin Jiang
Format: Article
Language:English
Published: PeerJ Inc. 2025-01-01
Series:PeerJ
Subjects:
Acute lung injury
Tetramethylpyrazine
scRNA-seq
Lipopolysaccharide
FOSL1
JunB
Online Access:https://peerj.com/articles/18772.pdf
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