Corneal higher-order aberrations as key predictive indicators of axial elongation in myopic children with orthokeratology: a single-center prospective cohort study
Abstract This prospective study aimed to investigate changes in corneal higher-order aberrations (HOAs) in myopic children using orthokeratology (ortho-k) lenses and their relationship with myopia progression. A total of 112 children aged 8–13 years were divided into group A (axial elongation ≤ 0.1 ...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-08-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-17115-w |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849226263379574784 |
|---|---|
| author | Ju Zhang Xiaoliang Zhang Ranyi Ding Yanan Ji Zhe Zhu Qingdong Bao Ting Wang Weiyun Shi |
| author_facet | Ju Zhang Xiaoliang Zhang Ranyi Ding Yanan Ji Zhe Zhu Qingdong Bao Ting Wang Weiyun Shi |
| author_sort | Ju Zhang |
| collection | DOAJ |
| description | Abstract This prospective study aimed to investigate changes in corneal higher-order aberrations (HOAs) in myopic children using orthokeratology (ortho-k) lenses and their relationship with myopia progression. A total of 112 children aged 8–13 years were divided into group A (axial elongation ≤ 0.1 mm/y with ortho-k) and group B (axial elongation > 0.1 mm/y with ortho-k). At baseline, 1, 6, and 12 months following the initiation of lens wear, HOAs and corneal peripheral defocus were evaluated. Ninety-three patients completed the 1-year follow-up. The mean axial elongation was − 0.07 ± 0.15 mm/y in group A, versus 0.32 ± 0.17 mm/y in group B. No statistical differences were observed in HOAs and corneal peripheral defocus at 1, 6, and 12 months (F = 0.653, 0.878; P > 0.05). Multivariate linear regression showed axial elongation was negatively correlated with ∆HOAs, peripheral defocus, and ∆horizontal coma (standardized beta=-0.331, -0.318, -0.209; P = 0.006, 0.001, 0.010, respectively) and positively correlated with the treatment zone diameter (standardized beta = 0.261, P = 0.003). Multivariate logistic regression identified ∆HOAs, peripheral defocus, ∆horizontal coma, and treatment zone as key factors distinguishing group A from group B (OR = 0.009, 0.455, 0.123, 12.172; P = 0.036, 0.003, 0.032, 0.019, respectively). The ROC curve for ∆HOAs had an area of 0.803 with a cut-off value of 0.834 μm. The ∆HOAs were more effective independent predictors of axial elongation than corneal peripheral defocus in children using ortho-k lenses. The ∆HOAs greater than 0.834 μm may lead to axial elongation ≤ 0.1 mm/y. These findings can be beneficial to fitting and optimizing ortho-k lenses. |
| format | Article |
| id | doaj-art-34a7026e036a4f658f7e13b2e2131ba3 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-34a7026e036a4f658f7e13b2e2131ba32025-08-24T11:26:39ZengNature PortfolioScientific Reports2045-23222025-08-0115111110.1038/s41598-025-17115-wCorneal higher-order aberrations as key predictive indicators of axial elongation in myopic children with orthokeratology: a single-center prospective cohort studyJu Zhang0Xiaoliang Zhang1Ranyi Ding2Yanan Ji3Zhe Zhu4Qingdong Bao5Ting Wang6Weiyun Shi7Shandong First Medical University and Shandong Academy of Medical SciencesEye Hospital of Shandong, Eye Institute of Shandong First Medical University, First Medical University (Shandong Eye Hospital)Eye Hospital of Shandong, Eye Institute of Shandong First Medical University, First Medical University (Shandong Eye Hospital)Eye Hospital of Shandong, Eye Institute of Shandong First Medical University, First Medical University (Shandong Eye Hospital)Shandong First Medical University and Shandong Academy of Medical SciencesShandong First Medical University and Shandong Academy of Medical SciencesEye Hospital of Shandong, Eye Institute of Shandong First Medical University, First Medical University (Shandong Eye Hospital)Eye Hospital of Shandong, Eye Institute of Shandong First Medical University, First Medical University (Shandong Eye Hospital)Abstract This prospective study aimed to investigate changes in corneal higher-order aberrations (HOAs) in myopic children using orthokeratology (ortho-k) lenses and their relationship with myopia progression. A total of 112 children aged 8–13 years were divided into group A (axial elongation ≤ 0.1 mm/y with ortho-k) and group B (axial elongation > 0.1 mm/y with ortho-k). At baseline, 1, 6, and 12 months following the initiation of lens wear, HOAs and corneal peripheral defocus were evaluated. Ninety-three patients completed the 1-year follow-up. The mean axial elongation was − 0.07 ± 0.15 mm/y in group A, versus 0.32 ± 0.17 mm/y in group B. No statistical differences were observed in HOAs and corneal peripheral defocus at 1, 6, and 12 months (F = 0.653, 0.878; P > 0.05). Multivariate linear regression showed axial elongation was negatively correlated with ∆HOAs, peripheral defocus, and ∆horizontal coma (standardized beta=-0.331, -0.318, -0.209; P = 0.006, 0.001, 0.010, respectively) and positively correlated with the treatment zone diameter (standardized beta = 0.261, P = 0.003). Multivariate logistic regression identified ∆HOAs, peripheral defocus, ∆horizontal coma, and treatment zone as key factors distinguishing group A from group B (OR = 0.009, 0.455, 0.123, 12.172; P = 0.036, 0.003, 0.032, 0.019, respectively). The ROC curve for ∆HOAs had an area of 0.803 with a cut-off value of 0.834 μm. The ∆HOAs were more effective independent predictors of axial elongation than corneal peripheral defocus in children using ortho-k lenses. The ∆HOAs greater than 0.834 μm may lead to axial elongation ≤ 0.1 mm/y. These findings can be beneficial to fitting and optimizing ortho-k lenses.https://doi.org/10.1038/s41598-025-17115-wOrthokeratology lensesHigher-order aberrationsPeripheral defocusMyopiaCorneal topography |
| spellingShingle | Ju Zhang Xiaoliang Zhang Ranyi Ding Yanan Ji Zhe Zhu Qingdong Bao Ting Wang Weiyun Shi Corneal higher-order aberrations as key predictive indicators of axial elongation in myopic children with orthokeratology: a single-center prospective cohort study Scientific Reports Orthokeratology lenses Higher-order aberrations Peripheral defocus Myopia Corneal topography |
| title | Corneal higher-order aberrations as key predictive indicators of axial elongation in myopic children with orthokeratology: a single-center prospective cohort study |
| title_full | Corneal higher-order aberrations as key predictive indicators of axial elongation in myopic children with orthokeratology: a single-center prospective cohort study |
| title_fullStr | Corneal higher-order aberrations as key predictive indicators of axial elongation in myopic children with orthokeratology: a single-center prospective cohort study |
| title_full_unstemmed | Corneal higher-order aberrations as key predictive indicators of axial elongation in myopic children with orthokeratology: a single-center prospective cohort study |
| title_short | Corneal higher-order aberrations as key predictive indicators of axial elongation in myopic children with orthokeratology: a single-center prospective cohort study |
| title_sort | corneal higher order aberrations as key predictive indicators of axial elongation in myopic children with orthokeratology a single center prospective cohort study |
| topic | Orthokeratology lenses Higher-order aberrations Peripheral defocus Myopia Corneal topography |
| url | https://doi.org/10.1038/s41598-025-17115-w |
| work_keys_str_mv | AT juzhang cornealhigherorderaberrationsaskeypredictiveindicatorsofaxialelongationinmyopicchildrenwithorthokeratologyasinglecenterprospectivecohortstudy AT xiaoliangzhang cornealhigherorderaberrationsaskeypredictiveindicatorsofaxialelongationinmyopicchildrenwithorthokeratologyasinglecenterprospectivecohortstudy AT ranyiding cornealhigherorderaberrationsaskeypredictiveindicatorsofaxialelongationinmyopicchildrenwithorthokeratologyasinglecenterprospectivecohortstudy AT yananji cornealhigherorderaberrationsaskeypredictiveindicatorsofaxialelongationinmyopicchildrenwithorthokeratologyasinglecenterprospectivecohortstudy AT zhezhu cornealhigherorderaberrationsaskeypredictiveindicatorsofaxialelongationinmyopicchildrenwithorthokeratologyasinglecenterprospectivecohortstudy AT qingdongbao cornealhigherorderaberrationsaskeypredictiveindicatorsofaxialelongationinmyopicchildrenwithorthokeratologyasinglecenterprospectivecohortstudy AT tingwang cornealhigherorderaberrationsaskeypredictiveindicatorsofaxialelongationinmyopicchildrenwithorthokeratologyasinglecenterprospectivecohortstudy AT weiyunshi cornealhigherorderaberrationsaskeypredictiveindicatorsofaxialelongationinmyopicchildrenwithorthokeratologyasinglecenterprospectivecohortstudy |