Re-analysis of the current status of clinical trial registration in China

ObjectiveTo reanalyze and summarize the current status and deficiencies of clinical trial registration in China, based on an analysis of the situation of clinical trial registration in the Chinese Clinical Trial Registry (ChiCTR).MethodsA search was conducted in China National Knowledge Infrastructu...

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Main Authors: Shuwen Li, Jianhao Li, Wenjing Zeng, Zhicheng Li, Jietong Zhang, Siying Wang, Nenggui Xu, Zeli Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Medicine
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Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2024.1394803/full
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author Shuwen Li
Shuwen Li
Jianhao Li
Wenjing Zeng
Zhicheng Li
Jietong Zhang
Siying Wang
Nenggui Xu
Zeli Li
Zeli Li
author_facet Shuwen Li
Shuwen Li
Jianhao Li
Wenjing Zeng
Zhicheng Li
Jietong Zhang
Siying Wang
Nenggui Xu
Zeli Li
Zeli Li
author_sort Shuwen Li
collection DOAJ
description ObjectiveTo reanalyze and summarize the current status and deficiencies of clinical trial registration in China, based on an analysis of the situation of clinical trial registration in the Chinese Clinical Trial Registry (ChiCTR).MethodsA search was conducted in China National Knowledge Infrastructure (CNKI), Chinese BioMedical Literature Database (CBM), Wangfang Data, VIP Database for Chinese Technical Periodicals (VIP), Web of Science (WoS), PubMed up to December 31, 2023, for literature on the analysis of clinical trial registration based on ChiCTR. NoteExpress software was used for screening, EXCEL for data organization and analysis, the Word Cloud website for constructing word frequency maps, and Origin software for visualization.ResultsAmong the 94 articles included, common analysis items included the number of registered projects, types of research, registration time, types of registration institutions, and regional distribution. Most of the included literature was funded. The publishing institutions involved 20 provinces/municipalities across the country, with hospitals being the majority of the publishing units. Most literature was submitted shortly after search completion and published shortly after submission, with more than half of the articles published in high-quality journals. The total average citation count of the literature was 3.34. The sources of clinical trial registration platforms analyzed in the literature were divided into three categories: single platform, dual platform, and multiple platforms.ConclusionChiCTR plays a key role in enhancing transparency in clinical research, promoting standardization and normalization of research, strengthening domestic and international scientific research cooperation, and advancing medical innovation and public health improvement. However, there are still issues with the quality of registration, focus areas, and the evaluation of registration quality.
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spelling doaj-art-34a5d132a834482eae83aab6817d75752025-01-31T13:35:05ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011110.3389/fmed.2024.13948031394803Re-analysis of the current status of clinical trial registration in ChinaShuwen Li0Shuwen Li1Jianhao Li2Wenjing Zeng3Zhicheng Li4Jietong Zhang5Siying Wang6Nenggui Xu7Zeli Li8Zeli Li9Dongguan Hospital of Guangzhou University of Chinese Medicine, Dongguan Traditional Chinese Medicine Hospital, Dongguan, ChinaClinical Medical College of Acu-Moxi and Rehabilitation, South China Research Center for Acupuncture and Moxibustion, Guangzhou University of Chinese Medicine, Guangzhou, ChinaSchool of Computer, Electronics and Information of Guangxi University, Nanning, ChinaClinical Medical College of Acu-Moxi and Rehabilitation, South China Research Center for Acupuncture and Moxibustion, Guangzhou University of Chinese Medicine, Guangzhou, ChinaClinical Medical College of Acu-Moxi and Rehabilitation, South China Research Center for Acupuncture and Moxibustion, Guangzhou University of Chinese Medicine, Guangzhou, ChinaGuangzhou University of Chinese Medicine, Guangzhou, ChinaGuangzhou University of Chinese Medicine, Guangzhou, ChinaClinical Medical College of Acu-Moxi and Rehabilitation, South China Research Center for Acupuncture and Moxibustion, Guangzhou University of Chinese Medicine, Guangzhou, ChinaDongguan Hospital of Guangzhou University of Chinese Medicine, Dongguan Traditional Chinese Medicine Hospital, Dongguan, ChinaClinical Medical College of Acu-Moxi and Rehabilitation, South China Research Center for Acupuncture and Moxibustion, Guangzhou University of Chinese Medicine, Guangzhou, ChinaObjectiveTo reanalyze and summarize the current status and deficiencies of clinical trial registration in China, based on an analysis of the situation of clinical trial registration in the Chinese Clinical Trial Registry (ChiCTR).MethodsA search was conducted in China National Knowledge Infrastructure (CNKI), Chinese BioMedical Literature Database (CBM), Wangfang Data, VIP Database for Chinese Technical Periodicals (VIP), Web of Science (WoS), PubMed up to December 31, 2023, for literature on the analysis of clinical trial registration based on ChiCTR. NoteExpress software was used for screening, EXCEL for data organization and analysis, the Word Cloud website for constructing word frequency maps, and Origin software for visualization.ResultsAmong the 94 articles included, common analysis items included the number of registered projects, types of research, registration time, types of registration institutions, and regional distribution. Most of the included literature was funded. The publishing institutions involved 20 provinces/municipalities across the country, with hospitals being the majority of the publishing units. Most literature was submitted shortly after search completion and published shortly after submission, with more than half of the articles published in high-quality journals. The total average citation count of the literature was 3.34. The sources of clinical trial registration platforms analyzed in the literature were divided into three categories: single platform, dual platform, and multiple platforms.ConclusionChiCTR plays a key role in enhancing transparency in clinical research, promoting standardization and normalization of research, strengthening domestic and international scientific research cooperation, and advancing medical innovation and public health improvement. However, there are still issues with the quality of registration, focus areas, and the evaluation of registration quality.https://www.frontiersin.org/articles/10.3389/fmed.2024.1394803/fullcurrent state of registrationChinese clinical trial registryevaluation of registration qualityre-analysisinsufficiency
spellingShingle Shuwen Li
Shuwen Li
Jianhao Li
Wenjing Zeng
Zhicheng Li
Jietong Zhang
Siying Wang
Nenggui Xu
Zeli Li
Zeli Li
Re-analysis of the current status of clinical trial registration in China
Frontiers in Medicine
current state of registration
Chinese clinical trial registry
evaluation of registration quality
re-analysis
insufficiency
title Re-analysis of the current status of clinical trial registration in China
title_full Re-analysis of the current status of clinical trial registration in China
title_fullStr Re-analysis of the current status of clinical trial registration in China
title_full_unstemmed Re-analysis of the current status of clinical trial registration in China
title_short Re-analysis of the current status of clinical trial registration in China
title_sort re analysis of the current status of clinical trial registration in china
topic current state of registration
Chinese clinical trial registry
evaluation of registration quality
re-analysis
insufficiency
url https://www.frontiersin.org/articles/10.3389/fmed.2024.1394803/full
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