Design of Mn(1,4-DO2A) derivatives as stable and inert contrast agents for magnetic resonance imaging

Design of Mn(1,4-DO2A) derivatives as stable and inert contrast agents for magnetic resonance imaging

Abstract Manganese(II) is considered a valuable alternative to gadolinium(III) in developing contrast agents (CAs) for magnetic resonance imaging (MRI). However, due to the labile nature of common Mn(II) complexes, designing ligands that enable stable and inert complexation is essential before clini...

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Main Authors: Weiyuan Xu, Zheng Cai, Fabio Carniato, Yi Lu, Xinjian Ye, Xinhui Xiao, Jiao Xu, Gengshen Mo, Yinghui Ding, Yong Jian, Xinzhong Ruan, Zhihan Yan, Fangfu Ye, Carlos Platas-Iglesias, Mauro Botta, Lixiong Dai
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-025-01615-x
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