Significant changes in gut microbiota and SCFAs among patients with newly diagnosed acute myeloid leukemia
The purpose of this study was to identify whether the gut microbiota and metabolites of newly diagnosed acute myeloid leukemia (AML) patients displayed specific characteristic alterations and whether these changes could be used as potential biomarkers for predicting the disease. Notably, the gut mic...
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| Format: | Article |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1559033/full |
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| author | Shujuan An Shujuan An Xia Gong Long Zhao Jinli Jian Yuancheng Guo Xiaoxiao Yang Hongjia Sun Hongjia Sun Yang Li Yang Li Bei Liu Bei Liu |
| author_facet | Shujuan An Shujuan An Xia Gong Long Zhao Jinli Jian Yuancheng Guo Xiaoxiao Yang Hongjia Sun Hongjia Sun Yang Li Yang Li Bei Liu Bei Liu |
| author_sort | Shujuan An |
| collection | DOAJ |
| description | The purpose of this study was to identify whether the gut microbiota and metabolites of newly diagnosed acute myeloid leukemia (AML) patients displayed specific characteristic alterations and whether these changes could be used as potential biomarkers for predicting the disease. Notably, the gut microbiota and metabolites of AML patients exhibited significant structural and quantitative alterations at the time of their initial diagnosis. Beneficial bacteria, including Faecalibacterium, Collinsella, Lacticaseibacillus, and Roseburia, as well as butyric acid and acetic acid, were found to be considerably reduced in newly diagnosed AML patients. In contrast, Enterococcus and Lactobacillus, especially Enterococcus, were significantly enriched. Further investigation indicated that Enterococcus could serve as a potential intestinal marker, showing a strong negative correlation with the levels of acetic and butyric acid. Importantly, assays aimed at identifying AML demonstrated that Enterococcus, butyric acid, and acetatic acid exhibited excellent predictive effectiveness. Colonizing Enterococcus from patients were isolated for pathogen investigation, which revealed that these bacteria possess several strong virulence factors and multiple drug-resistance gene characteristics. Therefore, we speculate that the increase of Enterococcus may contribute to the development and progression of AML. |
| format | Article |
| id | doaj-art-349b73682f754e388253b72c9a9aeb08 |
| institution | DOAJ |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-349b73682f754e388253b72c9a9aeb082025-08-20T03:04:35ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-04-011610.3389/fmicb.2025.15590331559033Significant changes in gut microbiota and SCFAs among patients with newly diagnosed acute myeloid leukemiaShujuan An0Shujuan An1Xia Gong2Long Zhao3Jinli Jian4Yuancheng Guo5Xiaoxiao Yang6Hongjia Sun7Hongjia Sun8Yang Li9Yang Li10Bei Liu11Bei Liu12The First Clinical Medical College, Lanzhou University, Lanzhou, ChinaDepartment of Medical Laboratory, The First Hospital of Lanzhou University, Lanzhou, ChinaDepartment of Medical Laboratory, The First Hospital of Lanzhou University, Lanzhou, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, ChinaDepartment of Medical Laboratory, The First Hospital of Lanzhou University, Lanzhou, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, ChinaDepartment of Medical Laboratory, The First Hospital of Lanzhou University, Lanzhou, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, ChinaDepartment of Haematology, The First Hospital of Lanzhou University, Lanzhou, ChinaThe purpose of this study was to identify whether the gut microbiota and metabolites of newly diagnosed acute myeloid leukemia (AML) patients displayed specific characteristic alterations and whether these changes could be used as potential biomarkers for predicting the disease. Notably, the gut microbiota and metabolites of AML patients exhibited significant structural and quantitative alterations at the time of their initial diagnosis. Beneficial bacteria, including Faecalibacterium, Collinsella, Lacticaseibacillus, and Roseburia, as well as butyric acid and acetic acid, were found to be considerably reduced in newly diagnosed AML patients. In contrast, Enterococcus and Lactobacillus, especially Enterococcus, were significantly enriched. Further investigation indicated that Enterococcus could serve as a potential intestinal marker, showing a strong negative correlation with the levels of acetic and butyric acid. Importantly, assays aimed at identifying AML demonstrated that Enterococcus, butyric acid, and acetatic acid exhibited excellent predictive effectiveness. Colonizing Enterococcus from patients were isolated for pathogen investigation, which revealed that these bacteria possess several strong virulence factors and multiple drug-resistance gene characteristics. Therefore, we speculate that the increase of Enterococcus may contribute to the development and progression of AML.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1559033/fullacute myeloid leukemiagut microbiotabutyric acidEnterococcusEnterococcus faecium |
| spellingShingle | Shujuan An Shujuan An Xia Gong Long Zhao Jinli Jian Yuancheng Guo Xiaoxiao Yang Hongjia Sun Hongjia Sun Yang Li Yang Li Bei Liu Bei Liu Significant changes in gut microbiota and SCFAs among patients with newly diagnosed acute myeloid leukemia Frontiers in Microbiology acute myeloid leukemia gut microbiota butyric acid Enterococcus Enterococcus faecium |
| title | Significant changes in gut microbiota and SCFAs among patients with newly diagnosed acute myeloid leukemia |
| title_full | Significant changes in gut microbiota and SCFAs among patients with newly diagnosed acute myeloid leukemia |
| title_fullStr | Significant changes in gut microbiota and SCFAs among patients with newly diagnosed acute myeloid leukemia |
| title_full_unstemmed | Significant changes in gut microbiota and SCFAs among patients with newly diagnosed acute myeloid leukemia |
| title_short | Significant changes in gut microbiota and SCFAs among patients with newly diagnosed acute myeloid leukemia |
| title_sort | significant changes in gut microbiota and scfas among patients with newly diagnosed acute myeloid leukemia |
| topic | acute myeloid leukemia gut microbiota butyric acid Enterococcus Enterococcus faecium |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1559033/full |
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