Assessment of pathomorphological characteristics of the oral mucosa in patients with HBV, HCV and HIV
Introduction: Oral clinical manifestations in HBV HCV and HIV patients indicate a deterioration in general health status. The aim of the study was to assess pathomorphologic features of oral mucosa observed in patients with these diseases. Methodology: The study was conducted in N1 Dental Clinic...
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The Journal of Infection in Developing Countries
2021-11-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/15062 |
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| author | Vahe Azatyan Lazar Yessayan Anna Khachatryan Anush Perikhanyan Alvard Hovhannisyan Melanya Shmavonyan Hasmik Ghazinyan Robert Gish Gayane Melik-Andreasyan Kristina Porksheyan |
| author_facet | Vahe Azatyan Lazar Yessayan Anna Khachatryan Anush Perikhanyan Alvard Hovhannisyan Melanya Shmavonyan Hasmik Ghazinyan Robert Gish Gayane Melik-Andreasyan Kristina Porksheyan |
| author_sort | Vahe Azatyan |
| collection | DOAJ |
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Introduction: Oral clinical manifestations in HBV HCV and HIV patients indicate a deterioration in general health status. The aim of the study was to assess pathomorphologic features of oral mucosa observed in patients with these diseases.
Methodology: The study was conducted in N1 Dental Clinic of YSMU after M. Heratsi. The total number of patients taking part in the research was 120, including HBV (n = 40), HCV (n = 40) and HIV (n = 40). After biopsy and subsequent histological examination of the oral mucosa, statistical analysis was carried out using Excel 2013 and R software.
Results: Pathomorphological examination revealed inflammatory infiltrations in all samples collected from HBV, HCV and HIV patients. These changes included microcirculatory disorders in 98.3% of samples: fibrinous-like deposits lining the surface of erosions and ulcers on the oral mucosa (1.67%), fibrosis of the mucous membrane (70%), dystrophy of squamous epithelium (93.3%) and bone sequestration (3.3%). Comparative analysis of pathomorphological characteristics revealed distinct content of infiltrates: lymphoplasmacytic infiltration in patients with HBV and HCV, while HIV patients showed neutrophils infiltration and lack of plasmocytes.
Conclusions: There are common abnormal morphological changes in the oral mucosa typical of all patients with HBV, HCV and HIV, as well as liver diseases specific to each of them. Inflammation in the patients with HIV indicated impairment of the humoral immune system. Understanding the distinct characteristic of inflammation in the oral cavity could be useful for early differential diagnosis and management of patients with HIV, HBV and HCV.
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| format | Article |
| id | doaj-art-349709f09cd74f7ba87d62b53becb4d7 |
| institution | DOAJ |
| issn | 1972-2680 |
| language | English |
| publishDate | 2021-11-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-349709f09cd74f7ba87d62b53becb4d72025-08-20T02:57:44ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802021-11-01151110.3855/jidc.15062Assessment of pathomorphological characteristics of the oral mucosa in patients with HBV, HCV and HIVVahe Azatyan0Lazar Yessayan1Anna Khachatryan2Anush Perikhanyan3Alvard Hovhannisyan4Melanya Shmavonyan5Hasmik Ghazinyan6Robert Gish7Gayane Melik-Andreasyan8Kristina Porksheyan9Department of Therapeutic Stomatology, Yerevan State Medical University (YSMU), Yerevan, ArmeniaDepartment of Therapeutic Stomatology, Yerevan State Medical University (YSMU), Yerevan, ArmeniaDepartment of Pathological Anatomy, Yerevan State Medical University (YSMU), Yerevan, ArmeniaDepartment of Medical Affairs, FMD Contract Research Organization, Yerevan, ArmeniaDepartment of Infectious Diseases, Yerevan State Medical University (YSMU), Yerevan, ArmeniaDepartment of Infectious Diseases, Yerevan State Medical University (YSMU), Yerevan, ArmeniaDepartment of Hepatology, Nork Clinical Infectious Hospital (CJSC), Yerevan, ArmeniaDepartment of Medicine, Stanford University Hospital, Stanford, California, United StatesNational Center of Disease Control and Prevention, RA Ministry of Health, Yerevan, ArmeniaDepartment of Diagnostic Radiology, Yerevan State Medical University (YSMU), Yerevan, Armenia Introduction: Oral clinical manifestations in HBV HCV and HIV patients indicate a deterioration in general health status. The aim of the study was to assess pathomorphologic features of oral mucosa observed in patients with these diseases. Methodology: The study was conducted in N1 Dental Clinic of YSMU after M. Heratsi. The total number of patients taking part in the research was 120, including HBV (n = 40), HCV (n = 40) and HIV (n = 40). After biopsy and subsequent histological examination of the oral mucosa, statistical analysis was carried out using Excel 2013 and R software. Results: Pathomorphological examination revealed inflammatory infiltrations in all samples collected from HBV, HCV and HIV patients. These changes included microcirculatory disorders in 98.3% of samples: fibrinous-like deposits lining the surface of erosions and ulcers on the oral mucosa (1.67%), fibrosis of the mucous membrane (70%), dystrophy of squamous epithelium (93.3%) and bone sequestration (3.3%). Comparative analysis of pathomorphological characteristics revealed distinct content of infiltrates: lymphoplasmacytic infiltration in patients with HBV and HCV, while HIV patients showed neutrophils infiltration and lack of plasmocytes. Conclusions: There are common abnormal morphological changes in the oral mucosa typical of all patients with HBV, HCV and HIV, as well as liver diseases specific to each of them. Inflammation in the patients with HIV indicated impairment of the humoral immune system. Understanding the distinct characteristic of inflammation in the oral cavity could be useful for early differential diagnosis and management of patients with HIV, HBV and HCV. https://jidc.org/index.php/journal/article/view/15062Histologyoral mucosaHBVHCVHIV |
| spellingShingle | Vahe Azatyan Lazar Yessayan Anna Khachatryan Anush Perikhanyan Alvard Hovhannisyan Melanya Shmavonyan Hasmik Ghazinyan Robert Gish Gayane Melik-Andreasyan Kristina Porksheyan Assessment of pathomorphological characteristics of the oral mucosa in patients with HBV, HCV and HIV Journal of Infection in Developing Countries Histology oral mucosa HBV HCV HIV |
| title | Assessment of pathomorphological characteristics of the oral mucosa in patients with HBV, HCV and HIV |
| title_full | Assessment of pathomorphological characteristics of the oral mucosa in patients with HBV, HCV and HIV |
| title_fullStr | Assessment of pathomorphological characteristics of the oral mucosa in patients with HBV, HCV and HIV |
| title_full_unstemmed | Assessment of pathomorphological characteristics of the oral mucosa in patients with HBV, HCV and HIV |
| title_short | Assessment of pathomorphological characteristics of the oral mucosa in patients with HBV, HCV and HIV |
| title_sort | assessment of pathomorphological characteristics of the oral mucosa in patients with hbv hcv and hiv |
| topic | Histology oral mucosa HBV HCV HIV |
| url | https://jidc.org/index.php/journal/article/view/15062 |
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