Single-cell multiomics reveals simvastatin inhibits pan-cancer epithelial-mesenchymal transition via the MEK/ERK pathway in XBP1+ mast cells

Single-cell multiomics reveals simvastatin inhibits pan-cancer epithelial-mesenchymal transition via the MEK/ERK pathway in XBP1+ mast cells

Abstract Distant metastasis is the leading cause of cancer-related mortality, and achieving survival benefits through advancements in systemic therapy remains challenging. Mast cells play a dual role in shaping the tumor microenvironment (TME) and influencing distant metastasis, underscoring the sig...

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Bibliographic Details
Main Authors: Sen Lin, Huimin Zhang, Ruiqi Zhao, Zhulin Wu, Weiqing Zhang, Mengjiao Yu, Bei Zhang, Lanyue Ma, Danfei Li, Lisheng Peng, Weijun Luo
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Pan-cancer
Distant metastasis
Mast cells
HMG-CoA reductase inhibitors
Multi-omics
Online Access:https://doi.org/10.1038/s41598-024-80858-5
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