Sex-disparities in pediatric and young adult patients with psoriasis treated with biologics: differences in adverse events and disease activity
Introduction Sex-differences in biological treatment outcomes in adult patients with psoriasis are well known. Potential sex-differences in a real-world cohort of pediatric and young adult patients with psoriasis using biologics were investigated in this study.Methods Data on pediatric (<18 years...
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Taylor & Francis Group
2025-12-01
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| Series: | Journal of Dermatological Treatment |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09546634.2025.2532672 |
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| author | Malak Al-Gawahiri Liana Barenbrug Ewald M. Bronkhorst Elke M. G. J. de Jong Juul M. P. A. van den Reek Marieke M. B. Seyger |
| author_facet | Malak Al-Gawahiri Liana Barenbrug Ewald M. Bronkhorst Elke M. G. J. de Jong Juul M. P. A. van den Reek Marieke M. B. Seyger |
| author_sort | Malak Al-Gawahiri |
| collection | DOAJ |
| description | Introduction Sex-differences in biological treatment outcomes in adult patients with psoriasis are well known. Potential sex-differences in a real-world cohort of pediatric and young adult patients with psoriasis using biologics were investigated in this study.Methods Data on pediatric (<18 years) and young adult (≥18 to ≤30 years) patients were obtained from the prospective, daily practice, ChildCAPTURE and BioCAPTURE registries. Drug survival and adverse event rates were compared between sexes. Confounder-corrected linear mixed models were used to compare Psoriasis Area and Severity Index (PASI) and (Children’s) Dermatology Life Quality Index ((C)DLQI) scores between sexes.Results We included 117 pediatric (65 females) and 243 young adult (124 females) patients on biologics (753.4 observation years). Young adult males had a significantly higher PASI at biologic initiation compared to females, with the same trend for pediatric patients. A higher adverse event rate was observed in females compared to males in both pediatric and young adult patients. Drug survival, PASI and (C)DLQI course during the first treatment year, were comparable between pediatric and young adult females and males.Conclusion Awareness on sex-differences (start PASI and adverse event rates) in pediatric and young adult patients with psoriasis is important for timely initiation and adjustment of appropriate treatment. |
| format | Article |
| id | doaj-art-348ddace79384fcabd07d2de47b4d6b4 |
| institution | DOAJ |
| issn | 0954-6634 1471-1753 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj-art-348ddace79384fcabd07d2de47b4d6b42025-08-20T03:15:09ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532025-12-0136110.1080/09546634.2025.2532672Sex-disparities in pediatric and young adult patients with psoriasis treated with biologics: differences in adverse events and disease activityMalak Al-Gawahiri0Liana Barenbrug1Ewald M. Bronkhorst2Elke M. G. J. de Jong3Juul M. P. A. van den Reek4Marieke M. B. Seyger5Department of Dermatology, Radboud University Medical Center, Nijmegen, The NetherlandsDepartment of Dermatology, Radboud University Medical Center, Nijmegen, The NetherlandsDepartment of IQ Health, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The NetherlandsDepartment of Dermatology, Radboud University Medical Center, Nijmegen, The NetherlandsDepartment of Dermatology, Radboud University Medical Center, Nijmegen, The NetherlandsDepartment of Dermatology, Radboud University Medical Center, Nijmegen, The NetherlandsIntroduction Sex-differences in biological treatment outcomes in adult patients with psoriasis are well known. Potential sex-differences in a real-world cohort of pediatric and young adult patients with psoriasis using biologics were investigated in this study.Methods Data on pediatric (<18 years) and young adult (≥18 to ≤30 years) patients were obtained from the prospective, daily practice, ChildCAPTURE and BioCAPTURE registries. Drug survival and adverse event rates were compared between sexes. Confounder-corrected linear mixed models were used to compare Psoriasis Area and Severity Index (PASI) and (Children’s) Dermatology Life Quality Index ((C)DLQI) scores between sexes.Results We included 117 pediatric (65 females) and 243 young adult (124 females) patients on biologics (753.4 observation years). Young adult males had a significantly higher PASI at biologic initiation compared to females, with the same trend for pediatric patients. A higher adverse event rate was observed in females compared to males in both pediatric and young adult patients. Drug survival, PASI and (C)DLQI course during the first treatment year, were comparable between pediatric and young adult females and males.Conclusion Awareness on sex-differences (start PASI and adverse event rates) in pediatric and young adult patients with psoriasis is important for timely initiation and adjustment of appropriate treatment.https://www.tandfonline.com/doi/10.1080/09546634.2025.2532672Pediatric dermatologypsoriasispediatric psoriasisbiologic treatmentsex-disparities |
| spellingShingle | Malak Al-Gawahiri Liana Barenbrug Ewald M. Bronkhorst Elke M. G. J. de Jong Juul M. P. A. van den Reek Marieke M. B. Seyger Sex-disparities in pediatric and young adult patients with psoriasis treated with biologics: differences in adverse events and disease activity Journal of Dermatological Treatment Pediatric dermatology psoriasis pediatric psoriasis biologic treatment sex-disparities |
| title | Sex-disparities in pediatric and young adult patients with psoriasis treated with biologics: differences in adverse events and disease activity |
| title_full | Sex-disparities in pediatric and young adult patients with psoriasis treated with biologics: differences in adverse events and disease activity |
| title_fullStr | Sex-disparities in pediatric and young adult patients with psoriasis treated with biologics: differences in adverse events and disease activity |
| title_full_unstemmed | Sex-disparities in pediatric and young adult patients with psoriasis treated with biologics: differences in adverse events and disease activity |
| title_short | Sex-disparities in pediatric and young adult patients with psoriasis treated with biologics: differences in adverse events and disease activity |
| title_sort | sex disparities in pediatric and young adult patients with psoriasis treated with biologics differences in adverse events and disease activity |
| topic | Pediatric dermatology psoriasis pediatric psoriasis biologic treatment sex-disparities |
| url | https://www.tandfonline.com/doi/10.1080/09546634.2025.2532672 |
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