SUSCEPTIBILITY OF BORDETELLA PERTUSSIS STRAINS TO ANTIBACTERIAL PREPARATIONS
178 strains of B. pertussis isolated from infected individuals in various regions of Russia from 1948 to 2012 have been studied for their susceptibility to six antibacterial preparations. It has been shown, that B. pertussis strains isolated from 1948 to 1989 were predominantly sensitive to erythrom...
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| Format: | Article |
| Language: | Russian |
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LLC "Diagnostics and Vaccines"
2015-08-01
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| Series: | Детские инфекции (Москва) |
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| Online Access: | https://detinf.elpub.ru/jour/article/view/97 |
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| author | O. Yu. Borisova A. V. Aleshkin G. A. Ivashinnikova E. E. Donskikh E. A. Postnikova V. A. Alyeshkin |
| author_facet | O. Yu. Borisova A. V. Aleshkin G. A. Ivashinnikova E. E. Donskikh E. A. Postnikova V. A. Alyeshkin |
| author_sort | O. Yu. Borisova |
| collection | DOAJ |
| description | 178 strains of B. pertussis isolated from infected individuals in various regions of Russia from 1948 to 2012 have been studied for their susceptibility to six antibacterial preparations. It has been shown, that B. pertussis strains isolated from 1948 to 1989 were predominantly sensitive to erythromycin. In the following years a gradual decrease in susceptibility of circulating strains of B. pertussis to this antibiotic was registered with the emergence of strains with intermediate susceptibility in 22% of cases from 1990 to 2005 (MIC 0,060 mcg/mL), up to 59,3% in the last six years (MIC 0,125 mcg/mL). As for azithromycin, high susceptibility of strains of B. pertussis to this preparation was shown throughout the entire duration of the survey. However, the rate of incidence of intermediate strains reached 14% among those strains isolated from 1990 to 2005, and is now at 32%. Thus, after several decades of active use of antibiotics pertussis underwent a series of transformations resulting in a decrease in susceptibility of B. pertussis strains to erythromycin and azithromycin. |
| format | Article |
| id | doaj-art-348bebb3a8a9472db436967e463c81b4 |
| institution | DOAJ |
| issn | 2072-8107 |
| language | Russian |
| publishDate | 2015-08-01 |
| publisher | LLC "Diagnostics and Vaccines" |
| record_format | Article |
| series | Детские инфекции (Москва) |
| spelling | doaj-art-348bebb3a8a9472db436967e463c81b42025-08-20T02:46:40ZrusLLC "Diagnostics and Vaccines"Детские инфекции (Москва)2072-81072015-08-01122465010.22627/2072-8107-2013-12-2-46-5097SUSCEPTIBILITY OF BORDETELLA PERTUSSIS STRAINS TO ANTIBACTERIAL PREPARATIONSO. Yu. Borisova0A. V. Aleshkin1G. A. Ivashinnikova2E. E. Donskikh3E. A. Postnikova4V. A. Alyeshkin5Moscow Research Institute of Epidemiology and Microbiology named after G.N. Gabrichevsky, MoscowMoscow Research Institute of Epidemiology and Microbiology named after G.N. Gabrichevsky, MoscowMoscow Research Institute of Epidemiology and Microbiology named after G.N. Gabrichevsky, MoscowRussian National Research Medical University named after N.I. Pirogov, MoscowRussian National Research Medical University named after N.I. Pirogov, MoscowMoscow Research Institute of Epidemiology and Microbiology named after G.N. Gabrichevsky, Moscow178 strains of B. pertussis isolated from infected individuals in various regions of Russia from 1948 to 2012 have been studied for their susceptibility to six antibacterial preparations. It has been shown, that B. pertussis strains isolated from 1948 to 1989 were predominantly sensitive to erythromycin. In the following years a gradual decrease in susceptibility of circulating strains of B. pertussis to this antibiotic was registered with the emergence of strains with intermediate susceptibility in 22% of cases from 1990 to 2005 (MIC 0,060 mcg/mL), up to 59,3% in the last six years (MIC 0,125 mcg/mL). As for azithromycin, high susceptibility of strains of B. pertussis to this preparation was shown throughout the entire duration of the survey. However, the rate of incidence of intermediate strains reached 14% among those strains isolated from 1990 to 2005, and is now at 32%. Thus, after several decades of active use of antibiotics pertussis underwent a series of transformations resulting in a decrease in susceptibility of B. pertussis strains to erythromycin and azithromycin.https://detinf.elpub.ru/jour/article/view/97bordetella pertussiscausative agent of pertussissusceptibility to antibiotics |
| spellingShingle | O. Yu. Borisova A. V. Aleshkin G. A. Ivashinnikova E. E. Donskikh E. A. Postnikova V. A. Alyeshkin SUSCEPTIBILITY OF BORDETELLA PERTUSSIS STRAINS TO ANTIBACTERIAL PREPARATIONS Детские инфекции (Москва) bordetella pertussis causative agent of pertussis susceptibility to antibiotics |
| title | SUSCEPTIBILITY OF BORDETELLA PERTUSSIS STRAINS TO ANTIBACTERIAL PREPARATIONS |
| title_full | SUSCEPTIBILITY OF BORDETELLA PERTUSSIS STRAINS TO ANTIBACTERIAL PREPARATIONS |
| title_fullStr | SUSCEPTIBILITY OF BORDETELLA PERTUSSIS STRAINS TO ANTIBACTERIAL PREPARATIONS |
| title_full_unstemmed | SUSCEPTIBILITY OF BORDETELLA PERTUSSIS STRAINS TO ANTIBACTERIAL PREPARATIONS |
| title_short | SUSCEPTIBILITY OF BORDETELLA PERTUSSIS STRAINS TO ANTIBACTERIAL PREPARATIONS |
| title_sort | susceptibility of bordetella pertussis strains to antibacterial preparations |
| topic | bordetella pertussis causative agent of pertussis susceptibility to antibiotics |
| url | https://detinf.elpub.ru/jour/article/view/97 |
| work_keys_str_mv | AT oyuborisova susceptibilityofbordetellapertussisstrainstoantibacterialpreparations AT avaleshkin susceptibilityofbordetellapertussisstrainstoantibacterialpreparations AT gaivashinnikova susceptibilityofbordetellapertussisstrainstoantibacterialpreparations AT eedonskikh susceptibilityofbordetellapertussisstrainstoantibacterialpreparations AT eapostnikova susceptibilityofbordetellapertussisstrainstoantibacterialpreparations AT vaalyeshkin susceptibilityofbordetellapertussisstrainstoantibacterialpreparations |