Correlation Between Serum Ferritin Levels and COVID-19 Severity: A Retrospective Cross-Sectional Study
Background and purpose: The levels of serum ferritin increase with increasing disease severity, thereby suggesting a possible biomarker for the prediction of the cytokine storm. This study was carried out to evaluate the practical utility of ferritin as a serum biomarker in COVID-19. Materials and m...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mazandaran University of Medical Sciences
2025-05-01
|
| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-20796-en.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849727666896240640 |
|---|---|
| author | Zeynab Marzhoseyni Zahra Shaghaghi Maryam Alvandi Seyyed Hamid Hashemi Mohammadreza Ghasemi basir Tieyb Mohamadi Soghra Farzipour |
| author_facet | Zeynab Marzhoseyni Zahra Shaghaghi Maryam Alvandi Seyyed Hamid Hashemi Mohammadreza Ghasemi basir Tieyb Mohamadi Soghra Farzipour |
| author_sort | Zeynab Marzhoseyni |
| collection | DOAJ |
| description | Background and purpose: The levels of serum ferritin increase with increasing disease severity, thereby suggesting a possible biomarker for the prediction of the cytokine storm. This study was carried out to evaluate the practical utility of ferritin as a serum biomarker in COVID-19.
Materials and methods: In this retrospective study, a total of 117 adult hospitalized patients with COVID-19 infection were included. The disease was diagnosed based on clinical signs and chest radiography, followed by real-time PCR. Patients were classified into mild-to-moderate (n= 47), severe (n = 46), and critical (n = 24) groups. Demographic and clinical information, as well as laboratory findings, were collected, and the concentrations of ferritin were compared among the different groups.
Results: The highest percentage of patients were in the critical group (76/29%). Overall, COVID-19 infection was more prevalent in females (66%) and the median age of patients in the critical group (76.29) was more than the other ones. The amount of ferritin was significantly higher in the critical (p< 0.001) group. The level of ferritin remarkably was higher in dead patients (620.88 ng/mL. Based on logistic regression analysis and ROC curve, ferritin can be a biomarker to predict high-risk patients. Furthermore, binary logistic regression showed ferritin to be a predictor of mortality supplemented.
Conclusion: Serum ferritin is a promising biomarker for anticipating cytokine storm, which may support clinical decision-making and contribute to the optimal management of patients with COVID-19. |
| format | Article |
| id | doaj-art-34874bfd82a3430382e1c5f072db9f06 |
| institution | DOAJ |
| issn | 1735-9260 1735-9279 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj-art-34874bfd82a3430382e1c5f072db9f062025-08-20T03:09:47ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792025-05-0135244169175Correlation Between Serum Ferritin Levels and COVID-19 Severity: A Retrospective Cross-Sectional StudyZeynab Marzhoseyni0Zahra Shaghaghi1Maryam Alvandi2Seyyed Hamid Hashemi3Mohammadreza Ghasemi basir4Tieyb Mohamadi5Soghra Farzipour6 Assistant Professor, Department of Paramedicine, Amol School of Paramedical Sciences, Mazandaran University of Medical Sciences, Sari, Iran Assistant Professor, Cancer Research Center, Hamadan University of Medical Sciences, Hamadan, Iran Professor, Department of Nuclear Medicine and Molecular Imaging, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran Professor, Department of Infectious Disaeses, Infectious Disease Research Center, Hamadan University of Medical Sciences, Hamadan, Iran 6 PhD Student in Biostatistics, Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran PhD Student in Nuclear Pharmacy, Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Background and purpose: The levels of serum ferritin increase with increasing disease severity, thereby suggesting a possible biomarker for the prediction of the cytokine storm. This study was carried out to evaluate the practical utility of ferritin as a serum biomarker in COVID-19. Materials and methods: In this retrospective study, a total of 117 adult hospitalized patients with COVID-19 infection were included. The disease was diagnosed based on clinical signs and chest radiography, followed by real-time PCR. Patients were classified into mild-to-moderate (n= 47), severe (n = 46), and critical (n = 24) groups. Demographic and clinical information, as well as laboratory findings, were collected, and the concentrations of ferritin were compared among the different groups. Results: The highest percentage of patients were in the critical group (76/29%). Overall, COVID-19 infection was more prevalent in females (66%) and the median age of patients in the critical group (76.29) was more than the other ones. The amount of ferritin was significantly higher in the critical (p< 0.001) group. The level of ferritin remarkably was higher in dead patients (620.88 ng/mL. Based on logistic regression analysis and ROC curve, ferritin can be a biomarker to predict high-risk patients. Furthermore, binary logistic regression showed ferritin to be a predictor of mortality supplemented. Conclusion: Serum ferritin is a promising biomarker for anticipating cytokine storm, which may support clinical decision-making and contribute to the optimal management of patients with COVID-19.http://jmums.mazums.ac.ir/article-1-20796-en.pdfferritincovid-19severitymortality |
| spellingShingle | Zeynab Marzhoseyni Zahra Shaghaghi Maryam Alvandi Seyyed Hamid Hashemi Mohammadreza Ghasemi basir Tieyb Mohamadi Soghra Farzipour Correlation Between Serum Ferritin Levels and COVID-19 Severity: A Retrospective Cross-Sectional Study Journal of Mazandaran University of Medical Sciences ferritin covid-19 severity mortality |
| title | Correlation Between Serum Ferritin Levels and COVID-19 Severity: A Retrospective Cross-Sectional Study |
| title_full | Correlation Between Serum Ferritin Levels and COVID-19 Severity: A Retrospective Cross-Sectional Study |
| title_fullStr | Correlation Between Serum Ferritin Levels and COVID-19 Severity: A Retrospective Cross-Sectional Study |
| title_full_unstemmed | Correlation Between Serum Ferritin Levels and COVID-19 Severity: A Retrospective Cross-Sectional Study |
| title_short | Correlation Between Serum Ferritin Levels and COVID-19 Severity: A Retrospective Cross-Sectional Study |
| title_sort | correlation between serum ferritin levels and covid 19 severity a retrospective cross sectional study |
| topic | ferritin covid-19 severity mortality |
| url | http://jmums.mazums.ac.ir/article-1-20796-en.pdf |
| work_keys_str_mv | AT zeynabmarzhoseyni correlationbetweenserumferritinlevelsandcovid19severityaretrospectivecrosssectionalstudy AT zahrashaghaghi correlationbetweenserumferritinlevelsandcovid19severityaretrospectivecrosssectionalstudy AT maryamalvandi correlationbetweenserumferritinlevelsandcovid19severityaretrospectivecrosssectionalstudy AT seyyedhamidhashemi correlationbetweenserumferritinlevelsandcovid19severityaretrospectivecrosssectionalstudy AT mohammadrezaghasemibasir correlationbetweenserumferritinlevelsandcovid19severityaretrospectivecrosssectionalstudy AT tieybmohamadi correlationbetweenserumferritinlevelsandcovid19severityaretrospectivecrosssectionalstudy AT soghrafarzipour correlationbetweenserumferritinlevelsandcovid19severityaretrospectivecrosssectionalstudy |