Correlation Between Serum Ferritin Levels and COVID-19 Severity: A Retrospective Cross-Sectional Study
Background and purpose: The levels of serum ferritin increase with increasing disease severity, thereby suggesting a possible biomarker for the prediction of the cytokine storm. This study was carried out to evaluate the practical utility of ferritin as a serum biomarker in COVID-19. Materials and m...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mazandaran University of Medical Sciences
2025-05-01
|
| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-20796-en.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Background and purpose: The levels of serum ferritin increase with increasing disease severity, thereby suggesting a possible biomarker for the prediction of the cytokine storm. This study was carried out to evaluate the practical utility of ferritin as a serum biomarker in COVID-19.
Materials and methods: In this retrospective study, a total of 117 adult hospitalized patients with COVID-19 infection were included. The disease was diagnosed based on clinical signs and chest radiography, followed by real-time PCR. Patients were classified into mild-to-moderate (n= 47), severe (n = 46), and critical (n = 24) groups. Demographic and clinical information, as well as laboratory findings, were collected, and the concentrations of ferritin were compared among the different groups.
Results: The highest percentage of patients were in the critical group (76/29%). Overall, COVID-19 infection was more prevalent in females (66%) and the median age of patients in the critical group (76.29) was more than the other ones. The amount of ferritin was significantly higher in the critical (p< 0.001) group. The level of ferritin remarkably was higher in dead patients (620.88 ng/mL. Based on logistic regression analysis and ROC curve, ferritin can be a biomarker to predict high-risk patients. Furthermore, binary logistic regression showed ferritin to be a predictor of mortality supplemented.
Conclusion: Serum ferritin is a promising biomarker for anticipating cytokine storm, which may support clinical decision-making and contribute to the optimal management of patients with COVID-19. |
|---|---|
| ISSN: | 1735-9260 1735-9279 |