Cross-talk of renal cells through WNT signal transduction in the development of fibrotic kidneys
Chronic kidney disease (CKD) is a progressive condition that can lead to chronic renal failure (CRF), affecting 8%–16% of adults globally and imposing a significant burden on healthcare systems. Renal fibrosis is a key pathological hallmark of CKD progression and is linked to poor prognosis. Multipl...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2024.1517181/full |
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| _version_ | 1823856570031669248 |
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| author | Yuhong Chen Chao Xue |
| author_facet | Yuhong Chen Chao Xue |
| author_sort | Yuhong Chen |
| collection | DOAJ |
| description | Chronic kidney disease (CKD) is a progressive condition that can lead to chronic renal failure (CRF), affecting 8%–16% of adults globally and imposing a significant burden on healthcare systems. Renal fibrosis is a key pathological hallmark of CKD progression and is linked to poor prognosis. Multiple signaling pathways, including WNT/β-catenin.Aberrant activation of WNT/β-catenin is implicated in renal fibrosis. The roles of renal macrophages and fibroblasts are pivotal in fibrosis progression and prognosis. |
| format | Article |
| id | doaj-art-34804d55d22040808fd2ebe4f966e3e9 |
| institution | Kabale University |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-34804d55d22040808fd2ebe4f966e3e92025-02-12T07:25:41ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-02-011210.3389/fcell.2024.15171811517181Cross-talk of renal cells through WNT signal transduction in the development of fibrotic kidneysYuhong ChenChao XueChronic kidney disease (CKD) is a progressive condition that can lead to chronic renal failure (CRF), affecting 8%–16% of adults globally and imposing a significant burden on healthcare systems. Renal fibrosis is a key pathological hallmark of CKD progression and is linked to poor prognosis. Multiple signaling pathways, including WNT/β-catenin.Aberrant activation of WNT/β-catenin is implicated in renal fibrosis. The roles of renal macrophages and fibroblasts are pivotal in fibrosis progression and prognosis.https://www.frontiersin.org/articles/10.3389/fcell.2024.1517181/fullcross-talkkidney fibrosiswnt/β-catenin signalingmacrophagefibroblast |
| spellingShingle | Yuhong Chen Chao Xue Cross-talk of renal cells through WNT signal transduction in the development of fibrotic kidneys Frontiers in Cell and Developmental Biology cross-talk kidney fibrosis wnt/β-catenin signaling macrophage fibroblast |
| title | Cross-talk of renal cells through WNT signal transduction in the development of fibrotic kidneys |
| title_full | Cross-talk of renal cells through WNT signal transduction in the development of fibrotic kidneys |
| title_fullStr | Cross-talk of renal cells through WNT signal transduction in the development of fibrotic kidneys |
| title_full_unstemmed | Cross-talk of renal cells through WNT signal transduction in the development of fibrotic kidneys |
| title_short | Cross-talk of renal cells through WNT signal transduction in the development of fibrotic kidneys |
| title_sort | cross talk of renal cells through wnt signal transduction in the development of fibrotic kidneys |
| topic | cross-talk kidney fibrosis wnt/β-catenin signaling macrophage fibroblast |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2024.1517181/full |
| work_keys_str_mv | AT yuhongchen crosstalkofrenalcellsthroughwntsignaltransductioninthedevelopmentoffibrotickidneys AT chaoxue crosstalkofrenalcellsthroughwntsignaltransductioninthedevelopmentoffibrotickidneys |