Cross-talk of renal cells through WNT signal transduction in the development of fibrotic kidneys
Chronic kidney disease (CKD) is a progressive condition that can lead to chronic renal failure (CRF), affecting 8%–16% of adults globally and imposing a significant burden on healthcare systems. Renal fibrosis is a key pathological hallmark of CKD progression and is linked to poor prognosis. Multipl...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2024.1517181/full |
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| Summary: | Chronic kidney disease (CKD) is a progressive condition that can lead to chronic renal failure (CRF), affecting 8%–16% of adults globally and imposing a significant burden on healthcare systems. Renal fibrosis is a key pathological hallmark of CKD progression and is linked to poor prognosis. Multiple signaling pathways, including WNT/β-catenin.Aberrant activation of WNT/β-catenin is implicated in renal fibrosis. The roles of renal macrophages and fibroblasts are pivotal in fibrosis progression and prognosis. |
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| ISSN: | 2296-634X |