Phytochemistry, Pharmacological Potential, and Ethnomedicinal Relevance of <i>Achillea nobilis</i> and Its Subspecies: A Comprehensive Review
<i>Achillea nobilis</i> and its subspecies (<i>A. nobilis</i> subsp. <i>neilreichii</i> and <i>A. nobilis</i> subsp. <i>sipylea</i>) have been traditionally used in various ethnomedical systems across Eurasia. However, comprehensive studies...
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2025-06-01
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| author | Anastassiya Shevchenko Aiman Аkhelova Shamshabanu Nokerbek Aigul Kaldybayeva Lyazzat Sagyndykova Karlygash Raganina Raushan Dossymbekova Aliya Meldebekova Akerke Amirkhanova Yerbol Ikhsanov Gulzhan Sauranbayeva Manshuk Kamalova Aidana Toregeldieva |
| author_facet | Anastassiya Shevchenko Aiman Аkhelova Shamshabanu Nokerbek Aigul Kaldybayeva Lyazzat Sagyndykova Karlygash Raganina Raushan Dossymbekova Aliya Meldebekova Akerke Amirkhanova Yerbol Ikhsanov Gulzhan Sauranbayeva Manshuk Kamalova Aidana Toregeldieva |
| author_sort | Anastassiya Shevchenko |
| collection | DOAJ |
| description | <i>Achillea nobilis</i> and its subspecies (<i>A. nobilis</i> subsp. <i>neilreichii</i> and <i>A. nobilis</i> subsp. <i>sipylea</i>) have been traditionally used in various ethnomedical systems across Eurasia. However, comprehensive studies on their phytochemical composition and pharmacological properties are still insufficient. This review aims to provide a critical synthesis of current knowledge regarding the botanical characteristics, geographic distribution, traditional applications, chemical constituents, and pharmacological effects of <i>A. nobilis</i> A structured search was conducted using eight scientific platforms, including Scopus, PubMed, Web of Science, Google Scholar, Science.gov, ScienceDirect, JSTOR, and BASE. Keywords related to phytochemistry, pharmacology, and ethnomedicine were applied, and a total of 28,000 records were initially retrieved. After a multi-stage screening process based on inclusion and exclusion criteria, 167 peer-reviewed publications from 1952 to 2023 were selected for detailed evaluation. Findings reveal a diverse range of bioactive compounds, such as flavonoids, monoterpenes, sesquiterpenes, and sesquiterpene lactones, which demonstrate antioxidant, antimicrobial, anti-inflammatory, antinociceptive, antispasmodic, and anticonvulsant activities. Most studies have focused on aerial parts and water-based extracts, while the root chemistry and organ-specific metabolite profiles remain largely unexplored. This review highlights the therapeutic potential of <i>A. nobilis</i> and underscores the need for future studies using multi-omics and advanced analytical techniques to support its development in pharmaceutical and nutraceutical applications. |
| format | Article |
| id | doaj-art-3477c7d217444b7580a8a66337beef0c |
| institution | DOAJ |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-06-01 |
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| spelling | doaj-art-3477c7d217444b7580a8a66337beef0c2025-08-20T03:11:19ZengMDPI AGMolecules1420-30492025-06-013011246010.3390/molecules30112460Phytochemistry, Pharmacological Potential, and Ethnomedicinal Relevance of <i>Achillea nobilis</i> and Its Subspecies: A Comprehensive ReviewAnastassiya Shevchenko0Aiman Аkhelova1Shamshabanu Nokerbek2Aigul Kaldybayeva3Lyazzat Sagyndykova4Karlygash Raganina5Raushan Dossymbekova6Aliya Meldebekova7Akerke Amirkhanova8Yerbol Ikhsanov9Gulzhan Sauranbayeva10Manshuk Kamalova11Aidana Toregeldieva12Higher School of Medicine, Al-Farabi Kazakh National University, Tole-bi 96, Almaty 050040, KazakhstanDepartment of Pharmaceutical and Toxicological Chemistry, S.D. Asfendiyarov Kazakh National Medical University, Tole-bi 94, Almaty 050012, KazakhstanSchool of Pharmacy, S.D. Asfendiyarov Kazakh National Medical University, Tole-bi 94, Almaty 050012, KazakhstanDepartment of Pharmaceutical and Toxicological Chemistry, S.D. Asfendiyarov Kazakh National Medical University, Tole-bi 94, Almaty 050012, KazakhstanDepartment of Pharmaceutical Disciplines, Astana Medical University, Saryarqa Ave., 33, Astana 010000, KazakhstanDepartment of Pharmaceutical Technology, S.D. Asfendiyarov Kazakh National Medical University, Tole-bi 94, Almaty 050012, KazakhstanDepartment of Biochemistry, S.D. Asfendiyarov Kazakh National Medical University, Tole-bi 94, Almaty 050012, KazakhstanDepartment of Biotechnology, Faculty of Biology and biotechnology, Al-Farabi Kazakh National University, Almaty 050040, KazakhstanDepartment of Pharmaceutical Technology, S.D. Asfendiyarov Kazakh National Medical University, Tole-bi 94, Almaty 050012, KazakhstanDepartment of Chemistry and Technology of Organic Substances, Natural Compounds and Polymers, Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty 050040, KazakhstanDepartment of Pharmaceutical and Toxicological Chemistry, S.D. Asfendiyarov Kazakh National Medical University, Tole-bi 94, Almaty 050012, KazakhstanHigher School of Medicine, Al-Farabi Kazakh National University, Tole-bi 96, Almaty 050040, KazakhstanHigher School of Medicine, Al-Farabi Kazakh National University, Tole-bi 96, Almaty 050040, Kazakhstan<i>Achillea nobilis</i> and its subspecies (<i>A. nobilis</i> subsp. <i>neilreichii</i> and <i>A. nobilis</i> subsp. <i>sipylea</i>) have been traditionally used in various ethnomedical systems across Eurasia. However, comprehensive studies on their phytochemical composition and pharmacological properties are still insufficient. This review aims to provide a critical synthesis of current knowledge regarding the botanical characteristics, geographic distribution, traditional applications, chemical constituents, and pharmacological effects of <i>A. nobilis</i> A structured search was conducted using eight scientific platforms, including Scopus, PubMed, Web of Science, Google Scholar, Science.gov, ScienceDirect, JSTOR, and BASE. Keywords related to phytochemistry, pharmacology, and ethnomedicine were applied, and a total of 28,000 records were initially retrieved. After a multi-stage screening process based on inclusion and exclusion criteria, 167 peer-reviewed publications from 1952 to 2023 were selected for detailed evaluation. Findings reveal a diverse range of bioactive compounds, such as flavonoids, monoterpenes, sesquiterpenes, and sesquiterpene lactones, which demonstrate antioxidant, antimicrobial, anti-inflammatory, antinociceptive, antispasmodic, and anticonvulsant activities. Most studies have focused on aerial parts and water-based extracts, while the root chemistry and organ-specific metabolite profiles remain largely unexplored. This review highlights the therapeutic potential of <i>A. nobilis</i> and underscores the need for future studies using multi-omics and advanced analytical techniques to support its development in pharmaceutical and nutraceutical applications.https://www.mdpi.com/1420-3049/30/11/2460ethnomedicinephytochemistryflavonoidsmonoterpenespharmacological activitiesantibacterial |
| spellingShingle | Anastassiya Shevchenko Aiman Аkhelova Shamshabanu Nokerbek Aigul Kaldybayeva Lyazzat Sagyndykova Karlygash Raganina Raushan Dossymbekova Aliya Meldebekova Akerke Amirkhanova Yerbol Ikhsanov Gulzhan Sauranbayeva Manshuk Kamalova Aidana Toregeldieva Phytochemistry, Pharmacological Potential, and Ethnomedicinal Relevance of <i>Achillea nobilis</i> and Its Subspecies: A Comprehensive Review Molecules ethnomedicine phytochemistry flavonoids monoterpenes pharmacological activities antibacterial |
| title | Phytochemistry, Pharmacological Potential, and Ethnomedicinal Relevance of <i>Achillea nobilis</i> and Its Subspecies: A Comprehensive Review |
| title_full | Phytochemistry, Pharmacological Potential, and Ethnomedicinal Relevance of <i>Achillea nobilis</i> and Its Subspecies: A Comprehensive Review |
| title_fullStr | Phytochemistry, Pharmacological Potential, and Ethnomedicinal Relevance of <i>Achillea nobilis</i> and Its Subspecies: A Comprehensive Review |
| title_full_unstemmed | Phytochemistry, Pharmacological Potential, and Ethnomedicinal Relevance of <i>Achillea nobilis</i> and Its Subspecies: A Comprehensive Review |
| title_short | Phytochemistry, Pharmacological Potential, and Ethnomedicinal Relevance of <i>Achillea nobilis</i> and Its Subspecies: A Comprehensive Review |
| title_sort | phytochemistry pharmacological potential and ethnomedicinal relevance of i achillea nobilis i and its subspecies a comprehensive review |
| topic | ethnomedicine phytochemistry flavonoids monoterpenes pharmacological activities antibacterial |
| url | https://www.mdpi.com/1420-3049/30/11/2460 |
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