Translational motions and radial oscillations of a polymer-coated microbubble in the focal cross-section of focused acoustic vortex
The polymer-coated microbubble stimulated by focused acoustic vortex has great potential in enhancing the targeted drug delivery, but the dynamic behaviors of the microbubble in the focal cross-section of focused acoustic vortex requires further investigation. A mathematical model, which accounts fo...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-08-01
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| Series: | Ultrasonics Sonochemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1350417725001841 |
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| author | Qingqin Zou Xiao Deng Zhihao Wang Shifang Guo Yujin Zong Dui Qin Mingxi Wan |
| author_facet | Qingqin Zou Xiao Deng Zhihao Wang Shifang Guo Yujin Zong Dui Qin Mingxi Wan |
| author_sort | Qingqin Zou |
| collection | DOAJ |
| description | The polymer-coated microbubble stimulated by focused acoustic vortex has great potential in enhancing the targeted drug delivery, but the dynamic behaviors of the microbubble in the focal cross-section of focused acoustic vortex requires further investigation. A mathematical model, which accounts for the acoustic radiation force, changes in the instantaneous acoustic field and the effects of shell properties, is developed to investigate the translational motions and radial oscillations of a polymer-coated microbubble excited by a focused acoustic vortex. Results show that in the focal cross-section, the microbubble in all cases moves in a direction consistent with the change of acoustic phase. The microbubble located at a relatively small initial distance from the focus moves toward the focus. However, once the initial distance exceeds a certain threshold, the microbubble moves away from the focus. Furthermore, a larger topological charge of the focused acoustic vortex results in a larger initial distance threshold. In regard to radial oscillations, the oscillation amplitude of microbubble decreases with an increase in the driving cycle due to its translational motion. Moreover, increasing the initial external radius of the microbubble or the velocity amplitude of the nth sectorial transducer enhances the translational motions and radial oscillations of the microbubble. Conversely, these dynamic behaviors are suppressed by increasing the topological charge, viscosity of the surrounding medium, shell viscoelasticity and thickness. This work comprehensively investigates the polymer-coated microbubble dynamics in the focal cross-section of focused acoustic vortex. It provides preliminary insights into the mechanism of combining focused acoustic vortex technology with polymer-coated microbubble for targeted drug delivery, which may contribute to optimization of experimental parameters settings. |
| format | Article |
| id | doaj-art-3475c50bd17f461d89d4c4233dd81d15 |
| institution | OA Journals |
| issn | 1350-4177 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ultrasonics Sonochemistry |
| spelling | doaj-art-3475c50bd17f461d89d4c4233dd81d152025-08-20T02:06:27ZengElsevierUltrasonics Sonochemistry1350-41772025-08-0111910740510.1016/j.ultsonch.2025.107405Translational motions and radial oscillations of a polymer-coated microbubble in the focal cross-section of focused acoustic vortexQingqin Zou0Xiao Deng1Zhihao Wang2Shifang Guo3Yujin Zong4Dui Qin5Mingxi Wan6Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi 710115, PR ChinaKey Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi 710115, PR ChinaKey Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi 710115, PR ChinaKey Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi 710115, PR ChinaKey Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi 710115, PR ChinaChongqing Engineering Research Center of Medical Electronics and Information Technology, Department of Biomedical Engineering, School of Life Health Information Science and Engineering, Chongqing University of Posts and Telecommunications, Chongqing 400065, PR China; Corresponding authors at: South of intersection of Hedi Road and Wutong East Road, Fengxi New Town, Xixian New District, Xi ’an, Shaanxi 710115, PR China.Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi 710115, PR China; Corresponding authors at: South of intersection of Hedi Road and Wutong East Road, Fengxi New Town, Xixian New District, Xi ’an, Shaanxi 710115, PR China.The polymer-coated microbubble stimulated by focused acoustic vortex has great potential in enhancing the targeted drug delivery, but the dynamic behaviors of the microbubble in the focal cross-section of focused acoustic vortex requires further investigation. A mathematical model, which accounts for the acoustic radiation force, changes in the instantaneous acoustic field and the effects of shell properties, is developed to investigate the translational motions and radial oscillations of a polymer-coated microbubble excited by a focused acoustic vortex. Results show that in the focal cross-section, the microbubble in all cases moves in a direction consistent with the change of acoustic phase. The microbubble located at a relatively small initial distance from the focus moves toward the focus. However, once the initial distance exceeds a certain threshold, the microbubble moves away from the focus. Furthermore, a larger topological charge of the focused acoustic vortex results in a larger initial distance threshold. In regard to radial oscillations, the oscillation amplitude of microbubble decreases with an increase in the driving cycle due to its translational motion. Moreover, increasing the initial external radius of the microbubble or the velocity amplitude of the nth sectorial transducer enhances the translational motions and radial oscillations of the microbubble. Conversely, these dynamic behaviors are suppressed by increasing the topological charge, viscosity of the surrounding medium, shell viscoelasticity and thickness. This work comprehensively investigates the polymer-coated microbubble dynamics in the focal cross-section of focused acoustic vortex. It provides preliminary insights into the mechanism of combining focused acoustic vortex technology with polymer-coated microbubble for targeted drug delivery, which may contribute to optimization of experimental parameters settings.http://www.sciencedirect.com/science/article/pii/S1350417725001841Focused acoustic vortexTranslational motions of microbubbleRadial oscillations of microbubblePolymer-coated microbubbleAcoustic radiation force |
| spellingShingle | Qingqin Zou Xiao Deng Zhihao Wang Shifang Guo Yujin Zong Dui Qin Mingxi Wan Translational motions and radial oscillations of a polymer-coated microbubble in the focal cross-section of focused acoustic vortex Ultrasonics Sonochemistry Focused acoustic vortex Translational motions of microbubble Radial oscillations of microbubble Polymer-coated microbubble Acoustic radiation force |
| title | Translational motions and radial oscillations of a polymer-coated microbubble in the focal cross-section of focused acoustic vortex |
| title_full | Translational motions and radial oscillations of a polymer-coated microbubble in the focal cross-section of focused acoustic vortex |
| title_fullStr | Translational motions and radial oscillations of a polymer-coated microbubble in the focal cross-section of focused acoustic vortex |
| title_full_unstemmed | Translational motions and radial oscillations of a polymer-coated microbubble in the focal cross-section of focused acoustic vortex |
| title_short | Translational motions and radial oscillations of a polymer-coated microbubble in the focal cross-section of focused acoustic vortex |
| title_sort | translational motions and radial oscillations of a polymer coated microbubble in the focal cross section of focused acoustic vortex |
| topic | Focused acoustic vortex Translational motions of microbubble Radial oscillations of microbubble Polymer-coated microbubble Acoustic radiation force |
| url | http://www.sciencedirect.com/science/article/pii/S1350417725001841 |
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