Effect of pre-conception serum vitamin D level on pregnancy outcomes in women undergoing in vitro fertilization with fresh embryo transfer: a retrospective analysis
Abstract Background This study aims to investigate the association of pre-conception vitamin D levels on adverse pregnancy outcomes in women undergoing in vitro fertilization with fresh embryo transfer. Methods This was a retrospective cohort study using archived serum 25-hydroxyvitamin D measured i...
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BMC
2025-01-01
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| Series: | Reproductive Biology and Endocrinology |
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| Online Access: | https://doi.org/10.1186/s12958-025-01343-w |
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| author | Aaron H. Y. Chan Jennifer K. Y. Ko Raymond H. W. Li Tat On Chan Ernest H. Y. Ng |
| author_facet | Aaron H. Y. Chan Jennifer K. Y. Ko Raymond H. W. Li Tat On Chan Ernest H. Y. Ng |
| author_sort | Aaron H. Y. Chan |
| collection | DOAJ |
| description | Abstract Background This study aims to investigate the association of pre-conception vitamin D levels on adverse pregnancy outcomes in women undergoing in vitro fertilization with fresh embryo transfer. Methods This was a retrospective cohort study using archived serum 25-hydroxyvitamin D measured in the pre-conception period before ovarian stimulation in patients undergoing in vitro fertilization with fresh autologous embryo transfer. A total of 306 women were included and adverse pregnancy outcomes in their resulting pregnancy were recorded. Patients who were vitamin D deficient (< 20ng/ml) were compared with those who were non-deficient (≥20ng/ml) and analysed for any association with adverse pregnancy outcomes. Results A total of 16/306 (5.3%) patients had hypertensive disorders of pregnancy (gestational hypertension and/or pre-eclampsia). The adjusted odds ratio for hypertensive disorders of pregnancy using vitamin D deficiency as a reference was 0.190 (95% CI 0.042–0.852) (p = 0.030). Other pregnancy complications were not significantly different with regards to pre-conception vitamin D status. Conclusions Pre-conception vitamin D deficiency is associated with an increased risk of hypertensive disorders in pregnancy in women undergoing in vitro fertilization with fresh embryo transfer. Trial registration HKUCTR 2361 (9th March 2018). |
| format | Article |
| id | doaj-art-347540d37df44b9cad4077010c9d74ba |
| institution | Kabale University |
| issn | 1477-7827 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj-art-347540d37df44b9cad4077010c9d74ba2025-01-12T12:44:51ZengBMCReproductive Biology and Endocrinology1477-78272025-01-012311710.1186/s12958-025-01343-wEffect of pre-conception serum vitamin D level on pregnancy outcomes in women undergoing in vitro fertilization with fresh embryo transfer: a retrospective analysisAaron H. Y. Chan0Jennifer K. Y. Ko1Raymond H. W. Li2Tat On Chan3Ernest H. Y. Ng4Department of Obstetrics and Gynaecology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative RegionDepartment of Obstetrics and Gynaecology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative RegionDepartment of Obstetrics and Gynaecology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative RegionDepartment of Obstetrics and Gynaecology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative RegionDepartment of Obstetrics and Gynaecology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative RegionAbstract Background This study aims to investigate the association of pre-conception vitamin D levels on adverse pregnancy outcomes in women undergoing in vitro fertilization with fresh embryo transfer. Methods This was a retrospective cohort study using archived serum 25-hydroxyvitamin D measured in the pre-conception period before ovarian stimulation in patients undergoing in vitro fertilization with fresh autologous embryo transfer. A total of 306 women were included and adverse pregnancy outcomes in their resulting pregnancy were recorded. Patients who were vitamin D deficient (< 20ng/ml) were compared with those who were non-deficient (≥20ng/ml) and analysed for any association with adverse pregnancy outcomes. Results A total of 16/306 (5.3%) patients had hypertensive disorders of pregnancy (gestational hypertension and/or pre-eclampsia). The adjusted odds ratio for hypertensive disorders of pregnancy using vitamin D deficiency as a reference was 0.190 (95% CI 0.042–0.852) (p = 0.030). Other pregnancy complications were not significantly different with regards to pre-conception vitamin D status. Conclusions Pre-conception vitamin D deficiency is associated with an increased risk of hypertensive disorders in pregnancy in women undergoing in vitro fertilization with fresh embryo transfer. Trial registration HKUCTR 2361 (9th March 2018).https://doi.org/10.1186/s12958-025-01343-wVitamin DPregnancyComplicationsIn vitro fertilizationIVFAdverse pregnancy outcomes |
| spellingShingle | Aaron H. Y. Chan Jennifer K. Y. Ko Raymond H. W. Li Tat On Chan Ernest H. Y. Ng Effect of pre-conception serum vitamin D level on pregnancy outcomes in women undergoing in vitro fertilization with fresh embryo transfer: a retrospective analysis Reproductive Biology and Endocrinology Vitamin D Pregnancy Complications In vitro fertilization IVF Adverse pregnancy outcomes |
| title | Effect of pre-conception serum vitamin D level on pregnancy outcomes in women undergoing in vitro fertilization with fresh embryo transfer: a retrospective analysis |
| title_full | Effect of pre-conception serum vitamin D level on pregnancy outcomes in women undergoing in vitro fertilization with fresh embryo transfer: a retrospective analysis |
| title_fullStr | Effect of pre-conception serum vitamin D level on pregnancy outcomes in women undergoing in vitro fertilization with fresh embryo transfer: a retrospective analysis |
| title_full_unstemmed | Effect of pre-conception serum vitamin D level on pregnancy outcomes in women undergoing in vitro fertilization with fresh embryo transfer: a retrospective analysis |
| title_short | Effect of pre-conception serum vitamin D level on pregnancy outcomes in women undergoing in vitro fertilization with fresh embryo transfer: a retrospective analysis |
| title_sort | effect of pre conception serum vitamin d level on pregnancy outcomes in women undergoing in vitro fertilization with fresh embryo transfer a retrospective analysis |
| topic | Vitamin D Pregnancy Complications In vitro fertilization IVF Adverse pregnancy outcomes |
| url | https://doi.org/10.1186/s12958-025-01343-w |
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