Liver Elastography Methods for Diagnosis of De Novo and Recurrent Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC), a common consequence of chronic liver disease, ranks among the most prevalent cancers globally and contributes significantly to cancer-related mortality. Liver fibrosis is intimately associated with hepatic function and the likelihood of future HCC occurrence. Despite...
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MDPI AG
2025-04-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/15/9/1087 |
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| author | Razvan Cerban Speranta Iacob Carmen Ester Mihaela Ghioca Mirela Chitul Razvan Iacob Liana Gheorghe |
| author_facet | Razvan Cerban Speranta Iacob Carmen Ester Mihaela Ghioca Mirela Chitul Razvan Iacob Liana Gheorghe |
| author_sort | Razvan Cerban |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC), a common consequence of chronic liver disease, ranks among the most prevalent cancers globally and contributes significantly to cancer-related mortality. Liver fibrosis is intimately associated with hepatic function and the likelihood of future HCC occurrence. Despite the fact that liver biopsy continues to be the gold standard for diagnosing fibrosis, its utility is hindered by cost and invasiveness, along with patient unease, procedural rejection, and potential adverse effects. Liver elastography has become a leading noninvasive means of assessing tissue stiffness with considerable diagnostic precision. Malignant tumors generally exhibit higher cellularity in comparison to benign ones, resulting in increased stiffness. Elastography techniques capitalize on alterations in tissue elasticity stemming from specific pathological or physiological processes. Technological innovations, such as advanced ultrasound imaging and artificial intelligence (AI)-integrated systems, are paving the way for enhanced diagnostic accuracy and risk prediction. Recent research underscores the potential of elastography in managing HCC patients, presenting novel clinical applications, including prediction of HCC development, differentiation between malignant and benign liver lesions, evaluating treatment response, and forecasting recurrence post-treatment, though certain findings remain contentious. Therefore, this review aims to sum up the latest advancements in liver elastography for HCC patients, outlining its applications while addressing existing limitations and avenues for future progress. |
| format | Article |
| id | doaj-art-3474037db49e4a0fbfc2a504e00f936b |
| institution | DOAJ |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-3474037db49e4a0fbfc2a504e00f936b2025-08-20T02:58:44ZengMDPI AGDiagnostics2075-44182025-04-01159108710.3390/diagnostics15091087Liver Elastography Methods for Diagnosis of De Novo and Recurrent Hepatocellular CarcinomaRazvan Cerban0Speranta Iacob1Carmen Ester2Mihaela Ghioca3Mirela Chitul4Razvan Iacob5Liana Gheorghe6Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaCenter for Digestive Diseases and Liver Transplant, Fundeni Clinical Institute, 022328 Bucharest, RomaniaFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaHepatocellular carcinoma (HCC), a common consequence of chronic liver disease, ranks among the most prevalent cancers globally and contributes significantly to cancer-related mortality. Liver fibrosis is intimately associated with hepatic function and the likelihood of future HCC occurrence. Despite the fact that liver biopsy continues to be the gold standard for diagnosing fibrosis, its utility is hindered by cost and invasiveness, along with patient unease, procedural rejection, and potential adverse effects. Liver elastography has become a leading noninvasive means of assessing tissue stiffness with considerable diagnostic precision. Malignant tumors generally exhibit higher cellularity in comparison to benign ones, resulting in increased stiffness. Elastography techniques capitalize on alterations in tissue elasticity stemming from specific pathological or physiological processes. Technological innovations, such as advanced ultrasound imaging and artificial intelligence (AI)-integrated systems, are paving the way for enhanced diagnostic accuracy and risk prediction. Recent research underscores the potential of elastography in managing HCC patients, presenting novel clinical applications, including prediction of HCC development, differentiation between malignant and benign liver lesions, evaluating treatment response, and forecasting recurrence post-treatment, though certain findings remain contentious. Therefore, this review aims to sum up the latest advancements in liver elastography for HCC patients, outlining its applications while addressing existing limitations and avenues for future progress.https://www.mdpi.com/2075-4418/15/9/1087liver elastographyhepatocellular carcinoma (HCC)liver fibrosis assessmentacoustic radiation force impulse (ARFI)tumor stiffnesstransient elastography (TE) |
| spellingShingle | Razvan Cerban Speranta Iacob Carmen Ester Mihaela Ghioca Mirela Chitul Razvan Iacob Liana Gheorghe Liver Elastography Methods for Diagnosis of De Novo and Recurrent Hepatocellular Carcinoma Diagnostics liver elastography hepatocellular carcinoma (HCC) liver fibrosis assessment acoustic radiation force impulse (ARFI) tumor stiffness transient elastography (TE) |
| title | Liver Elastography Methods for Diagnosis of De Novo and Recurrent Hepatocellular Carcinoma |
| title_full | Liver Elastography Methods for Diagnosis of De Novo and Recurrent Hepatocellular Carcinoma |
| title_fullStr | Liver Elastography Methods for Diagnosis of De Novo and Recurrent Hepatocellular Carcinoma |
| title_full_unstemmed | Liver Elastography Methods for Diagnosis of De Novo and Recurrent Hepatocellular Carcinoma |
| title_short | Liver Elastography Methods for Diagnosis of De Novo and Recurrent Hepatocellular Carcinoma |
| title_sort | liver elastography methods for diagnosis of de novo and recurrent hepatocellular carcinoma |
| topic | liver elastography hepatocellular carcinoma (HCC) liver fibrosis assessment acoustic radiation force impulse (ARFI) tumor stiffness transient elastography (TE) |
| url | https://www.mdpi.com/2075-4418/15/9/1087 |
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