Conjugated Lithocholic Acid Activates Hepatic TGR5 to Promote Lipotoxicity and MASLD‐MASH Transition by Disrupting Carnitine Biosynthesis

Conjugated Lithocholic Acid Activates Hepatic TGR5 to Promote Lipotoxicity and MASLD‐MASH Transition by Disrupting Carnitine Biosynthesis

Abstract Conjugated lithocholic acid (LCA) plays a critical role in the development of metabolic dysfunction‐associated steatotic liver disease (MASLD). In this process, hepatocyte inflammation‐caused upregulation of its receptor, Takeda G protein‐coupled receptor 5 (TGR5) is a crucial factor. Serum...

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Bibliographic Details
Main Authors: Senlin Lian, Meixi Lu, Luo Jiajing, Bin Zhang, Yi Fang, Xuran Wang, Minghua Zheng, Yan Ni, Guifang Xu, Yonglin Yang, Runqiu Jiang
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Advanced Science
Subjects:
carnitine
gamma‐butyrobetaine hydroxylase 1
Gpbar1
MASH
secondary bile acids
TRIM21
Online Access:https://doi.org/10.1002/advs.202410602
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