The anionic surfactant Sodium Dodecyl Benzene Sulfonate alleviates inflammatory responses in atopic dermatitis via NFκB/MAPK pathways in a STAT3-dependent manner
Abstract Atopic dermatitis (AD) is a common chronic inflammatory skin disease characterized by chronic inflammation, barrier impairment, and immunoglobulin E-mediated sensitization. Sodium dodecyl benzene sulfonate (SDBS) is a widely used anionic surfactant which are believed to exacerbate AD accord...
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Nature Portfolio
2025-07-01
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| Online Access: | https://doi.org/10.1038/s41598-025-12776-z |
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| author | Han Zhang Zizhuo Li Zhanglei Mu You Wu Suli Zhang Yaguang Zhou Dongdong Zhang Xiaojing Zhao Weiwei Xing Yanan Wang Biwen Lin Xiaoqiang Liang Chunfu Zheng Chengxin Li Jianzhong Zhang |
| author_facet | Han Zhang Zizhuo Li Zhanglei Mu You Wu Suli Zhang Yaguang Zhou Dongdong Zhang Xiaojing Zhao Weiwei Xing Yanan Wang Biwen Lin Xiaoqiang Liang Chunfu Zheng Chengxin Li Jianzhong Zhang |
| author_sort | Han Zhang |
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| description | Abstract Atopic dermatitis (AD) is a common chronic inflammatory skin disease characterized by chronic inflammation, barrier impairment, and immunoglobulin E-mediated sensitization. Sodium dodecyl benzene sulfonate (SDBS) is a widely used anionic surfactant which are believed to exacerbate AD according to the hygiene hypothesis. However, recent studies have shown that SDBS does not significantly upregulate the expression of key proinflammatory cytokines, which is inconsistent with previous hypotheses. Furthermore, it is not known whether SDBS affect the inflammatory response to AD. Herein, we used mice with MC903-induced AD-like dermatitis and tumor necrosis factor (TNF)-α/interferon (IFN)-γ (T/I)-treated HaCaT cells to investigate the effects of SDBS on AD. We found that topical use of 0.1% and 1% SDBS did not exacerbate dermatitis in mice. Instead, clinical and histological remission of MC903-induced AD-like dermatitis were observed following the administration of both 0.1% and 1% SDBS, where 1% SDBS treatment showed a greater degree of relief compared to 0.1% SDBS. SDBS also reduced the expression of major cytokines involved in the pathogenesis of AD both in vivo and in vitro. Furthermore, our results showed that SDBS alleviated AD via the nuclear factor kappa B/mitogen-activated protein kinase pathways in a signal transducer and activator of transcription 3-dependent manner. In conclusion, our findings suggest for the first time that the surfactant SDBS has anti-inflammatory properties, which raises new possibilities for detergent use among patients with AD. |
| format | Article |
| id | doaj-art-34645832db9241c3bb6329fe2633be78 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-34645832db9241c3bb6329fe2633be782025-08-20T04:02:46ZengNature PortfolioScientific Reports2045-23222025-07-0115111310.1038/s41598-025-12776-zThe anionic surfactant Sodium Dodecyl Benzene Sulfonate alleviates inflammatory responses in atopic dermatitis via NFκB/MAPK pathways in a STAT3-dependent mannerHan Zhang0Zizhuo Li1Zhanglei Mu2You Wu3Suli Zhang4Yaguang Zhou5Dongdong Zhang6Xiaojing Zhao7Weiwei Xing8Yanan Wang9Biwen Lin10Xiaoqiang Liang11Chunfu Zheng12Chengxin Li13Jianzhong Zhang14Department of Dermatology, The First Medical Center of Chinese PLA General HospitalDepartment of Dermatology, The First Medical Center of Chinese PLA General HospitalDepartment of Dermatology, Peking University People’s HospitalDepartment of Dermatology, The First Medical Center of Chinese PLA General HospitalDepartment of Dermatology, The First Medical Center of Chinese PLA General HospitalDepartment of Dermatology, The First Medical Center of Chinese PLA General HospitalSchool of Life Sciences, Westlake UniversityMedical Innovation Research Division of Chinese PLA General HospitalBeijing Institute of Basic Medical SciencesCapital Medical University Electric Power Teaching Hospital/State Grid Beijing Electric Power HospitalDepartment of Dermatology, The First Medical Center of Chinese PLA General HospitalDepartment of Dermatology, The First Medical Center of Chinese PLA General HospitalDepartment of Microbiology, Immunology and Infectious Diseases, University of CalgaryDepartment of Dermatology, The First Medical Center of Chinese PLA General HospitalDepartment of Dermatology, Peking University People’s HospitalAbstract Atopic dermatitis (AD) is a common chronic inflammatory skin disease characterized by chronic inflammation, barrier impairment, and immunoglobulin E-mediated sensitization. Sodium dodecyl benzene sulfonate (SDBS) is a widely used anionic surfactant which are believed to exacerbate AD according to the hygiene hypothesis. However, recent studies have shown that SDBS does not significantly upregulate the expression of key proinflammatory cytokines, which is inconsistent with previous hypotheses. Furthermore, it is not known whether SDBS affect the inflammatory response to AD. Herein, we used mice with MC903-induced AD-like dermatitis and tumor necrosis factor (TNF)-α/interferon (IFN)-γ (T/I)-treated HaCaT cells to investigate the effects of SDBS on AD. We found that topical use of 0.1% and 1% SDBS did not exacerbate dermatitis in mice. Instead, clinical and histological remission of MC903-induced AD-like dermatitis were observed following the administration of both 0.1% and 1% SDBS, where 1% SDBS treatment showed a greater degree of relief compared to 0.1% SDBS. SDBS also reduced the expression of major cytokines involved in the pathogenesis of AD both in vivo and in vitro. Furthermore, our results showed that SDBS alleviated AD via the nuclear factor kappa B/mitogen-activated protein kinase pathways in a signal transducer and activator of transcription 3-dependent manner. In conclusion, our findings suggest for the first time that the surfactant SDBS has anti-inflammatory properties, which raises new possibilities for detergent use among patients with AD.https://doi.org/10.1038/s41598-025-12776-zAtopic dermatitisSodium Dodecyl benzene sulfonateSurfactants |
| spellingShingle | Han Zhang Zizhuo Li Zhanglei Mu You Wu Suli Zhang Yaguang Zhou Dongdong Zhang Xiaojing Zhao Weiwei Xing Yanan Wang Biwen Lin Xiaoqiang Liang Chunfu Zheng Chengxin Li Jianzhong Zhang The anionic surfactant Sodium Dodecyl Benzene Sulfonate alleviates inflammatory responses in atopic dermatitis via NFκB/MAPK pathways in a STAT3-dependent manner Scientific Reports Atopic dermatitis Sodium Dodecyl benzene sulfonate Surfactants |
| title | The anionic surfactant Sodium Dodecyl Benzene Sulfonate alleviates inflammatory responses in atopic dermatitis via NFκB/MAPK pathways in a STAT3-dependent manner |
| title_full | The anionic surfactant Sodium Dodecyl Benzene Sulfonate alleviates inflammatory responses in atopic dermatitis via NFκB/MAPK pathways in a STAT3-dependent manner |
| title_fullStr | The anionic surfactant Sodium Dodecyl Benzene Sulfonate alleviates inflammatory responses in atopic dermatitis via NFκB/MAPK pathways in a STAT3-dependent manner |
| title_full_unstemmed | The anionic surfactant Sodium Dodecyl Benzene Sulfonate alleviates inflammatory responses in atopic dermatitis via NFκB/MAPK pathways in a STAT3-dependent manner |
| title_short | The anionic surfactant Sodium Dodecyl Benzene Sulfonate alleviates inflammatory responses in atopic dermatitis via NFκB/MAPK pathways in a STAT3-dependent manner |
| title_sort | anionic surfactant sodium dodecyl benzene sulfonate alleviates inflammatory responses in atopic dermatitis via nfκb mapk pathways in a stat3 dependent manner |
| topic | Atopic dermatitis Sodium Dodecyl benzene sulfonate Surfactants |
| url | https://doi.org/10.1038/s41598-025-12776-z |
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