Case Report: Improvement of diplopia due to severe internuclear ophthalmoplegia by 4-aminopyridine documented using a novel virtual reality-based oculography headset

Internuclear ophthalmoplegia (INO) is an eye movement disorder that occurs in approximately one-third of people with multiple sclerosis (MS). We used a novel, head-mounted, virtual reality (VR)-based oculography device (PRET™, machineMD AG, Switzerland) to objectively measure oculomotor symptoms rep...

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Main Authors: Emilie Reuter, Justus Luerweg, Ruth Schneider, Rafael Klimas, Jeremias Motte, Ralf Gold, Anke Salmen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Virtual Reality
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Online Access:https://www.frontiersin.org/articles/10.3389/frvir.2025.1595694/full
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Summary:Internuclear ophthalmoplegia (INO) is an eye movement disorder that occurs in approximately one-third of people with multiple sclerosis (MS). We used a novel, head-mounted, virtual reality (VR)-based oculography device (PRET™, machineMD AG, Switzerland) to objectively measure oculomotor symptoms reported by a patient with MS to aid in the clinical diagnosis confirmation of INO. The patient’s symptoms, primarily diplopia, were managed successfully with 4-aminopyridine. The VR-based eye-tracking tool documented the subjective improvement in oculomotor function tracking treatment effects.
ISSN:2673-4192