Concomitant Use of Topiramate Inducing Neutropenia in a Schizophrenic Male Stabilized on Clozapine
This is a case of a 23-year-old African American male with a history of paranoid schizophrenia that developed neutropenia on a clozapine-topiramate therapy. Clozapine had well addressed the patient’s psychotic symptoms, while topiramate was used as a weight-lowering agent. The patient had fairly sta...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Psychiatry |
| Online Access: | http://dx.doi.org/10.1155/2016/6086839 |
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| author | Pravesh Sharma Jeffrey Davis Vivekananda Rachamallu Manish Aligeti |
| author_facet | Pravesh Sharma Jeffrey Davis Vivekananda Rachamallu Manish Aligeti |
| author_sort | Pravesh Sharma |
| collection | DOAJ |
| description | This is a case of a 23-year-old African American male with a history of paranoid schizophrenia that developed neutropenia on a clozapine-topiramate therapy. Clozapine had well addressed the patient’s psychotic symptoms, while topiramate was used as a weight-lowering agent. The patient had fairly stable leukocyte counts for eight months on clozapine 300 mg and topiramate 100 mg daily. Doubling the dosage of topiramate led to severe neutropenia after two months. Reviewing the patient’s laboratory reports showed a gradual decline of neutrophils occurring at a lower dosage, followed by a rapid decline after an increased dosage. In this case, we report that not only did topiramate act as the neutropenic agent, but also it might have done so in a dose-dependent manner. |
| format | Article |
| id | doaj-art-34619e2bf0de4097b118344e272f1238 |
| institution | Kabale University |
| issn | 2090-682X 2090-6838 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Psychiatry |
| spelling | doaj-art-34619e2bf0de4097b118344e272f12382025-02-03T06:13:36ZengWileyCase Reports in Psychiatry2090-682X2090-68382016-01-01201610.1155/2016/60868396086839Concomitant Use of Topiramate Inducing Neutropenia in a Schizophrenic Male Stabilized on ClozapinePravesh Sharma0Jeffrey Davis1Vivekananda Rachamallu2Manish Aligeti3Department of Psychiatry, Texas Tech University Health Sciences Center, 3601 4th Street, Stop 8103, Lubbock, TX 79430, USADepartment of Psychiatry, Texas Tech University Health Sciences Center, 3601 4th Street, Stop 8103, Lubbock, TX 79430, USADepartment of Psychiatry, Texas Tech University Health Sciences Center, 3601 4th Street, Stop 8103, Lubbock, TX 79430, USADepartment of Psychiatry, Texas Tech University Health Sciences Center, 3601 4th Street, Stop 8103, Lubbock, TX 79430, USAThis is a case of a 23-year-old African American male with a history of paranoid schizophrenia that developed neutropenia on a clozapine-topiramate therapy. Clozapine had well addressed the patient’s psychotic symptoms, while topiramate was used as a weight-lowering agent. The patient had fairly stable leukocyte counts for eight months on clozapine 300 mg and topiramate 100 mg daily. Doubling the dosage of topiramate led to severe neutropenia after two months. Reviewing the patient’s laboratory reports showed a gradual decline of neutrophils occurring at a lower dosage, followed by a rapid decline after an increased dosage. In this case, we report that not only did topiramate act as the neutropenic agent, but also it might have done so in a dose-dependent manner.http://dx.doi.org/10.1155/2016/6086839 |
| spellingShingle | Pravesh Sharma Jeffrey Davis Vivekananda Rachamallu Manish Aligeti Concomitant Use of Topiramate Inducing Neutropenia in a Schizophrenic Male Stabilized on Clozapine Case Reports in Psychiatry |
| title | Concomitant Use of Topiramate Inducing Neutropenia in a Schizophrenic Male Stabilized on Clozapine |
| title_full | Concomitant Use of Topiramate Inducing Neutropenia in a Schizophrenic Male Stabilized on Clozapine |
| title_fullStr | Concomitant Use of Topiramate Inducing Neutropenia in a Schizophrenic Male Stabilized on Clozapine |
| title_full_unstemmed | Concomitant Use of Topiramate Inducing Neutropenia in a Schizophrenic Male Stabilized on Clozapine |
| title_short | Concomitant Use of Topiramate Inducing Neutropenia in a Schizophrenic Male Stabilized on Clozapine |
| title_sort | concomitant use of topiramate inducing neutropenia in a schizophrenic male stabilized on clozapine |
| url | http://dx.doi.org/10.1155/2016/6086839 |
| work_keys_str_mv | AT praveshsharma concomitantuseoftopiramateinducingneutropeniainaschizophrenicmalestabilizedonclozapine AT jeffreydavis concomitantuseoftopiramateinducingneutropeniainaschizophrenicmalestabilizedonclozapine AT vivekanandarachamallu concomitantuseoftopiramateinducingneutropeniainaschizophrenicmalestabilizedonclozapine AT manishaligeti concomitantuseoftopiramateinducingneutropeniainaschizophrenicmalestabilizedonclozapine |