Do fasting or high caloric drinks affect the physiological uptake of fluorine-18 prostate-specific membrane antigen-1007 in liver and bowel?
Recently introduced fluorine-18 prostate-specific membrane antigen-1007 (18F-PSMA-1007) for imaging prostate cancer has an intense physiologic liver uptake and biliary excretion. The aim of the present study was to evaluate the effect of different dietary conditions on this physiological uptake. For...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical and Scientific Publishers Pvt. Ltd.
2020-07-01
|
| Series: | World Journal of Nuclear Medicine |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/wjnm.WJNM_6_19 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850045357066551296 |
|---|---|
| author | Kambiz Rahbar Ali Afshar-Oromieh Robert Seifert Stefan Wagner Michael Schäfers Martin Bögemann Matthias Weckesser |
| author_facet | Kambiz Rahbar Ali Afshar-Oromieh Robert Seifert Stefan Wagner Michael Schäfers Martin Bögemann Matthias Weckesser |
| author_sort | Kambiz Rahbar |
| collection | DOAJ |
| description | Recently introduced fluorine-18 prostate-specific membrane antigen-1007 (18F-PSMA-1007) for imaging prostate cancer has an intense physiologic liver uptake and biliary excretion. The aim of the present study was to evaluate the effect of different dietary conditions on this physiological uptake. Forty consecutive prostate cancer patients were scanned with 18F-PSMA-1007 positron emission tomography/computed tomography at different dietary conditions. In addition to a blinded read scoring, tracer uptake intensities (standardized uptake values [SUVs]) were measured in the liver and small bowel. There was no significant difference in liver and small-bowel uptake between different patient groups. Wilcoxon signed-rank tests revealed no significant difference of the median mean SUV of the liver or maximum SUV of the horizontal part of the duodenum between different dietary conditions groups. A dietary preparation of patients by fasting or the attempt to clear liver activity by high caloric drinks does not have a significant effect on tracer uptake in the liver or in the small bowel. |
| format | Article |
| id | doaj-art-345d4ac11ac14ad0bf219dfc2d2ea221 |
| institution | DOAJ |
| issn | 1450-1147 1607-3312 |
| language | English |
| publishDate | 2020-07-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | World Journal of Nuclear Medicine |
| spelling | doaj-art-345d4ac11ac14ad0bf219dfc2d2ea2212025-08-20T02:54:43ZengThieme Medical and Scientific Publishers Pvt. Ltd.World Journal of Nuclear Medicine1450-11471607-33122020-07-01190322022310.4103/wjnm.WJNM_6_19Do fasting or high caloric drinks affect the physiological uptake of fluorine-18 prostate-specific membrane antigen-1007 in liver and bowel?Kambiz Rahbar0Ali Afshar-Oromieh1Robert Seifert2Stefan Wagner3Michael Schäfers4Martin Bögemann5Matthias Weckesser6Department of Nuclear Medicine, University Hospital Münster, MünsterDepartment of Nuclear Medicine, University Hospital of Heidelberg, GermanyDepartment of Nuclear Medicine, University Hospital Münster, MünsterDepartment of Nuclear Medicine, University Hospital Münster, MünsterDepartment of Nuclear Medicine, University Hospital Münster, MünsterDepartment of Urology, University Hospital Münster, MünsterDepartment of Nuclear Medicine, University Hospital Münster, MünsterRecently introduced fluorine-18 prostate-specific membrane antigen-1007 (18F-PSMA-1007) for imaging prostate cancer has an intense physiologic liver uptake and biliary excretion. The aim of the present study was to evaluate the effect of different dietary conditions on this physiological uptake. Forty consecutive prostate cancer patients were scanned with 18F-PSMA-1007 positron emission tomography/computed tomography at different dietary conditions. In addition to a blinded read scoring, tracer uptake intensities (standardized uptake values [SUVs]) were measured in the liver and small bowel. There was no significant difference in liver and small-bowel uptake between different patient groups. Wilcoxon signed-rank tests revealed no significant difference of the median mean SUV of the liver or maximum SUV of the horizontal part of the duodenum between different dietary conditions groups. A dietary preparation of patients by fasting or the attempt to clear liver activity by high caloric drinks does not have a significant effect on tracer uptake in the liver or in the small bowel.http://www.thieme-connect.de/DOI/DOI?10.4103/wjnm.WJNM_6_19positron emission tomography/computed tomographyprostate cancerprostate-specific membrane antigen-1007 |
| spellingShingle | Kambiz Rahbar Ali Afshar-Oromieh Robert Seifert Stefan Wagner Michael Schäfers Martin Bögemann Matthias Weckesser Do fasting or high caloric drinks affect the physiological uptake of fluorine-18 prostate-specific membrane antigen-1007 in liver and bowel? World Journal of Nuclear Medicine positron emission tomography/computed tomography prostate cancer prostate-specific membrane antigen-1007 |
| title | Do fasting or high caloric drinks affect the physiological uptake of fluorine-18 prostate-specific membrane antigen-1007 in liver and bowel? |
| title_full | Do fasting or high caloric drinks affect the physiological uptake of fluorine-18 prostate-specific membrane antigen-1007 in liver and bowel? |
| title_fullStr | Do fasting or high caloric drinks affect the physiological uptake of fluorine-18 prostate-specific membrane antigen-1007 in liver and bowel? |
| title_full_unstemmed | Do fasting or high caloric drinks affect the physiological uptake of fluorine-18 prostate-specific membrane antigen-1007 in liver and bowel? |
| title_short | Do fasting or high caloric drinks affect the physiological uptake of fluorine-18 prostate-specific membrane antigen-1007 in liver and bowel? |
| title_sort | do fasting or high caloric drinks affect the physiological uptake of fluorine 18 prostate specific membrane antigen 1007 in liver and bowel |
| topic | positron emission tomography/computed tomography prostate cancer prostate-specific membrane antigen-1007 |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/wjnm.WJNM_6_19 |
| work_keys_str_mv | AT kambizrahbar dofastingorhighcaloricdrinksaffectthephysiologicaluptakeoffluorine18prostatespecificmembraneantigen1007inliverandbowel AT aliafsharoromieh dofastingorhighcaloricdrinksaffectthephysiologicaluptakeoffluorine18prostatespecificmembraneantigen1007inliverandbowel AT robertseifert dofastingorhighcaloricdrinksaffectthephysiologicaluptakeoffluorine18prostatespecificmembraneantigen1007inliverandbowel AT stefanwagner dofastingorhighcaloricdrinksaffectthephysiologicaluptakeoffluorine18prostatespecificmembraneantigen1007inliverandbowel AT michaelschafers dofastingorhighcaloricdrinksaffectthephysiologicaluptakeoffluorine18prostatespecificmembraneantigen1007inliverandbowel AT martinbogemann dofastingorhighcaloricdrinksaffectthephysiologicaluptakeoffluorine18prostatespecificmembraneantigen1007inliverandbowel AT matthiasweckesser dofastingorhighcaloricdrinksaffectthephysiologicaluptakeoffluorine18prostatespecificmembraneantigen1007inliverandbowel |