In Vitro Insulin Resistance Model: A Recent Update
Insulin resistance, which affects insulin-sensitive tissues, including adipose tissues, skeletal muscle, and the liver, is the central pathophysiological mechanism underlying type 2 diabetes progression. Decreased glucose uptake in insulin-sensitive tissues disrupts insulin signaling pathways, parti...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2023/1964732 |
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| author | Ratih D. Yudhani Yulia Sari Dwi A. A. Nugrahaningsih Eti N. Sholikhah Maftuchah Rochmanti Abdul K. R. Purba Husnul Khotimah Dian Nugrahenny Mustofa Mustofa |
| author_facet | Ratih D. Yudhani Yulia Sari Dwi A. A. Nugrahaningsih Eti N. Sholikhah Maftuchah Rochmanti Abdul K. R. Purba Husnul Khotimah Dian Nugrahenny Mustofa Mustofa |
| author_sort | Ratih D. Yudhani |
| collection | DOAJ |
| description | Insulin resistance, which affects insulin-sensitive tissues, including adipose tissues, skeletal muscle, and the liver, is the central pathophysiological mechanism underlying type 2 diabetes progression. Decreased glucose uptake in insulin-sensitive tissues disrupts insulin signaling pathways, particularly the PI3K/Akt pathway. An in vitro model is appropriate for studying the cellular and molecular mechanisms underlying insulin resistance because it is easy to maintain and the results can be easily reproduced. The application of cell-based models for exploring the pathogenesis of diabetes and insulin resistance as well as for developing drugs for these conditions is well known. However, a comprehensive review of in vitro insulin resistance models is lacking. Therefore, this review was conducted to provide a comprehensive overview and summary of the latest in vitro insulin resistance models, particularly 3T3-L1 (preadipocyte), C2C12 (skeletal muscle), and HepG2 (liver) cell lines induced with palmitic acid, high glucose, or chronic exposure to insulin. |
| format | Article |
| id | doaj-art-345ba6b0775948638903f8b7916e735c |
| institution | DOAJ |
| issn | 2090-0716 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-345ba6b0775948638903f8b7916e735c2025-08-20T03:18:35ZengWileyJournal of Obesity2090-07162023-01-01202310.1155/2023/1964732In Vitro Insulin Resistance Model: A Recent UpdateRatih D. Yudhani0Yulia Sari1Dwi A. A. Nugrahaningsih2Eti N. Sholikhah3Maftuchah Rochmanti4Abdul K. R. Purba5Husnul Khotimah6Dian Nugrahenny7Mustofa Mustofa8Department of PharmacologyDepartment of ParasitologyDepartment of Pharmacology and TherapyDepartment of Pharmacology and TherapyDepartment of AnatomyDepartment of AnatomyDepartment of PharmacologyDepartment of PharmacologyDepartment of Pharmacology and TherapyInsulin resistance, which affects insulin-sensitive tissues, including adipose tissues, skeletal muscle, and the liver, is the central pathophysiological mechanism underlying type 2 diabetes progression. Decreased glucose uptake in insulin-sensitive tissues disrupts insulin signaling pathways, particularly the PI3K/Akt pathway. An in vitro model is appropriate for studying the cellular and molecular mechanisms underlying insulin resistance because it is easy to maintain and the results can be easily reproduced. The application of cell-based models for exploring the pathogenesis of diabetes and insulin resistance as well as for developing drugs for these conditions is well known. However, a comprehensive review of in vitro insulin resistance models is lacking. Therefore, this review was conducted to provide a comprehensive overview and summary of the latest in vitro insulin resistance models, particularly 3T3-L1 (preadipocyte), C2C12 (skeletal muscle), and HepG2 (liver) cell lines induced with palmitic acid, high glucose, or chronic exposure to insulin.http://dx.doi.org/10.1155/2023/1964732 |
| spellingShingle | Ratih D. Yudhani Yulia Sari Dwi A. A. Nugrahaningsih Eti N. Sholikhah Maftuchah Rochmanti Abdul K. R. Purba Husnul Khotimah Dian Nugrahenny Mustofa Mustofa In Vitro Insulin Resistance Model: A Recent Update Journal of Obesity |
| title | In Vitro Insulin Resistance Model: A Recent Update |
| title_full | In Vitro Insulin Resistance Model: A Recent Update |
| title_fullStr | In Vitro Insulin Resistance Model: A Recent Update |
| title_full_unstemmed | In Vitro Insulin Resistance Model: A Recent Update |
| title_short | In Vitro Insulin Resistance Model: A Recent Update |
| title_sort | in vitro insulin resistance model a recent update |
| url | http://dx.doi.org/10.1155/2023/1964732 |
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