Mitochondrial damage in muscle specific PolG mutant mice activates the integrated stress response and disrupts the mitochondrial folate cycle

Mitochondrial damage in muscle specific PolG mutant mice activates the integrated stress response and disrupts the mitochondrial folate cycle

Abstract During mitochondrial damage, information is relayed between the mitochondria and nucleus to coordinate precise responses to preserve cellular health. One such pathway is the mitochondrial integrated stress response (mtISR), which is known to be activated by mitochondrial DNA (mtDNA) damage....

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Main Authors: Simon T. Bond, Emily J. King, Shannen M. Walker, Christine Yang, Yingying Liu, Kevin H. Liu, Aowen Zhuang, Aaron W. Jurrjens, Haoyun A. Fang, Luke E. Formosa, Artika P. Nath, Sergio Ruiz Carmona, Michael Inouye, Thy Duong, Kevin Huynh, Peter J. Meikle, Simon Crawford, Georg Ramm, Sheik Nadeem Elahee Doomun, David P. de Souza, Danielle L. Rudler, Anna C. Calkin, Aleksandra Filipovska, David W. Greening, Darren C. Henstridge, Brian G. Drew
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57299-3
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