Exploring the genetic progression of MDR1 in Plasmodium falciparum: A decade of multi-regional genetic analysis (2014–2024)
Summary: Background: The genetic progression of the MDR1 gene in Plasmodium falciparum, a key factor in drug resistance, presents significant challenges for malaria control. This study aims to elucidate the genetic diversity and evolutionary dynamics of P. falciparum, particularly focusing on the M...
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Elsevier
2024-01-01
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| Series: | Current Research in Microbial Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666517424000877 |
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| author | Olugbenga Ayodeji Mokuolu George Oche Ambrose Mohammed Baba Abdulkadir Selimat Ibrahim Itiolu Ibilola Funsho Toluwani Mokuolu |
| author_facet | Olugbenga Ayodeji Mokuolu George Oche Ambrose Mohammed Baba Abdulkadir Selimat Ibrahim Itiolu Ibilola Funsho Toluwani Mokuolu |
| author_sort | Olugbenga Ayodeji Mokuolu |
| collection | DOAJ |
| description | Summary: Background: The genetic progression of the MDR1 gene in Plasmodium falciparum, a key factor in drug resistance, presents significant challenges for malaria control. This study aims to elucidate the genetic diversity and evolutionary dynamics of P. falciparum, particularly focusing on the MDR1 gene across multi-regional populations. To analyze the genetic diversity of P. falciparum MDR1 gene across various multi-regional populations between 2014 and 2024, assessing allelic richness, genetic distances, and evolutionary patterns. Methods: We conducted an extensive genetic analysis using methods such as Analysis of Molecular Variance (AMOVA), pairwise population matrices of Nei unbiased genetic distance and identity, PhiPT and Phi'PT values, and Principal Coordinates Analysis (PCoA). The study covered diverse P. falciparum populations from India, Nigeria, Ethiopia, Honduras, China, and Cameroon. Findings: Our findings reveal significant genetic heterogeneity in the MDR1 gene. Populations like India: Odisha (2014) exhibited high allelic richness, indicating diverse drug resistance profiles. Notable genetic divergence was observed, especially between India (2016) and Nigeria (2020), suggesting different evolutionary trajectories in drug resistance. The PCoA analysis highlighted the multi-dimensional genetic variation, reflecting the complex interplay of factors influencing drug resistance in P. falciparum. Interpretation: The comprehensive analysis of P. falciparum's MDR1 gene provides crucial insights into the multi-regional patterns of drug resistance. This knowledge is essential for developing effective malaria control measures and adapting treatment strategies to the evolving genetic diversity of the parasite. |
| format | Article |
| id | doaj-art-345a7b12a7dd4d1d8efe9b492ff5ddbd |
| institution | OA Journals |
| issn | 2666-5174 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Microbial Sciences |
| spelling | doaj-art-345a7b12a7dd4d1d8efe9b492ff5ddbd2025-08-20T02:30:32ZengElsevierCurrent Research in Microbial Sciences2666-51742024-01-01710030410.1016/j.crmicr.2024.100304Exploring the genetic progression of MDR1 in Plasmodium falciparum: A decade of multi-regional genetic analysis (2014–2024)Olugbenga Ayodeji Mokuolu0George Oche Ambrose1 Mohammed Baba Abdulkadir2Selimat Ibrahim3Itiolu Ibilola Funsho4Toluwani Mokuolu5Department of Paediatrics and Child Health, University of Ilorin, Ilorin, Nigeria; Centre for Malaria and Other Tropical Diseases Care, University of Ilorin Teaching Hospital, Ilorin, NigeriaCentre for Malaria and Other Tropical Diseases Care, University of Ilorin Teaching Hospital, Ilorin, Nigeria; Corresponding author.Department of Paediatrics and Child Health, University of Ilorin, Ilorin, Nigeria; Centre for Malaria and Other Tropical Diseases Care, University of Ilorin Teaching Hospital, Ilorin, NigeriaCentre for Malaria and Other Tropical Diseases Care, University of Ilorin Teaching Hospital, Ilorin, NigeriaCentre for Malaria and Other Tropical Diseases Care, University of Ilorin Teaching Hospital, Ilorin, NigeriaCentre for Malaria and Other Tropical Diseases Care, University of Ilorin Teaching Hospital, Ilorin, NigeriaSummary: Background: The genetic progression of the MDR1 gene in Plasmodium falciparum, a key factor in drug resistance, presents significant challenges for malaria control. This study aims to elucidate the genetic diversity and evolutionary dynamics of P. falciparum, particularly focusing on the MDR1 gene across multi-regional populations. To analyze the genetic diversity of P. falciparum MDR1 gene across various multi-regional populations between 2014 and 2024, assessing allelic richness, genetic distances, and evolutionary patterns. Methods: We conducted an extensive genetic analysis using methods such as Analysis of Molecular Variance (AMOVA), pairwise population matrices of Nei unbiased genetic distance and identity, PhiPT and Phi'PT values, and Principal Coordinates Analysis (PCoA). The study covered diverse P. falciparum populations from India, Nigeria, Ethiopia, Honduras, China, and Cameroon. Findings: Our findings reveal significant genetic heterogeneity in the MDR1 gene. Populations like India: Odisha (2014) exhibited high allelic richness, indicating diverse drug resistance profiles. Notable genetic divergence was observed, especially between India (2016) and Nigeria (2020), suggesting different evolutionary trajectories in drug resistance. The PCoA analysis highlighted the multi-dimensional genetic variation, reflecting the complex interplay of factors influencing drug resistance in P. falciparum. Interpretation: The comprehensive analysis of P. falciparum's MDR1 gene provides crucial insights into the multi-regional patterns of drug resistance. This knowledge is essential for developing effective malaria control measures and adapting treatment strategies to the evolving genetic diversity of the parasite.http://www.sciencedirect.com/science/article/pii/S2666517424000877MDR1 geneP. falciparumGenetic diversityEvolutionary dynamicsMalaria |
| spellingShingle | Olugbenga Ayodeji Mokuolu George Oche Ambrose Mohammed Baba Abdulkadir Selimat Ibrahim Itiolu Ibilola Funsho Toluwani Mokuolu Exploring the genetic progression of MDR1 in Plasmodium falciparum: A decade of multi-regional genetic analysis (2014–2024) Current Research in Microbial Sciences MDR1 gene P. falciparum Genetic diversity Evolutionary dynamics Malaria |
| title | Exploring the genetic progression of MDR1 in Plasmodium falciparum: A decade of multi-regional genetic analysis (2014–2024) |
| title_full | Exploring the genetic progression of MDR1 in Plasmodium falciparum: A decade of multi-regional genetic analysis (2014–2024) |
| title_fullStr | Exploring the genetic progression of MDR1 in Plasmodium falciparum: A decade of multi-regional genetic analysis (2014–2024) |
| title_full_unstemmed | Exploring the genetic progression of MDR1 in Plasmodium falciparum: A decade of multi-regional genetic analysis (2014–2024) |
| title_short | Exploring the genetic progression of MDR1 in Plasmodium falciparum: A decade of multi-regional genetic analysis (2014–2024) |
| title_sort | exploring the genetic progression of mdr1 in plasmodium falciparum a decade of multi regional genetic analysis 2014 2024 |
| topic | MDR1 gene P. falciparum Genetic diversity Evolutionary dynamics Malaria |
| url | http://www.sciencedirect.com/science/article/pii/S2666517424000877 |
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