Galectin-3 Marker Expression in Renal Cell Carcinoma and Correlation with patient Clinicopathologic Factors: A cross-sectional study
Background: Renal Cell Carcinoma is one of the most common malignancies worldwide. To date, multiple attempts had been made to accurately diagnose it and predict its behavior. One of the most intriguing biomarkers that have been assessed since 90s, is galectin-3. This study aimed to increase the pri...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Babol University of Medical Sciences
2025-10-01
|
| Series: | Caspian Journal of Internal Medicine |
| Subjects: | |
| Online Access: | http://caspjim.com/article-1-4326-en.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846171028156317696 |
|---|---|
| author | Ghodsieh Kamrani Reza Havaspour Mohammad Ranaee Hamid Shafi Hoda Shirafkan Mohammad Ebrahim Sohrabi Davoud Jahansouz |
| author_facet | Ghodsieh Kamrani Reza Havaspour Mohammad Ranaee Hamid Shafi Hoda Shirafkan Mohammad Ebrahim Sohrabi Davoud Jahansouz |
| author_sort | Ghodsieh Kamrani |
| collection | DOAJ |
| description | Background: Renal Cell Carcinoma is one of the most common malignancies worldwide. To date, multiple attempts had been made to accurately diagnose it and predict its behavior. One of the most intriguing biomarkers that have been assessed since 90s, is galectin-3. This study aimed to increase the prior knowledge of galectin-3 expression association with patient's clinicopathologic factors.
Methods: In this single-center cross-sectional study, 71 patient samples from hospital archive were assessed for galectin-3 expression by immunohistochemistry assay. Pathologic slides were evaluated for histologic subtype, grade, stage, tumor size, presence of necrosis, and invasion of the renal vein. By adding cytoplasmic staining score to the color intensity score, a final score was recorded as galectin-3 positivity score.
Results: 88 pathological slides of patients with confirmed RCC were screened and 71 were finally assessed. The mean age of the patients was 58.52 years (lowest 30 and highest 87). 67.6% were males and 32.4% were females. 68% of tumors were clear cell carcinoma, and only one oncocytoma was present. All 9 chromophobe cases showed a strong galectin-3 expression. Except for female gender (47.8% vs 18.8% in men; P=0.01), no statistically significant association was found between patient age, tumor grade, tumor size, tumor stage, and renal vein invasion with the level of galectin-3 expression.
Conclusion: Considering the contradictory findings between this study and other similar studies, it can be concluded that the physiological role of galectins is very complex and the need for larger and more comprehensive evaluations is felt. |
| format | Article |
| id | doaj-art-3459a4e1df464930ae908b33d1b38221 |
| institution | Kabale University |
| issn | 2008-6164 2008-6172 |
| language | English |
| publishDate | 2025-10-01 |
| publisher | Babol University of Medical Sciences |
| record_format | Article |
| series | Caspian Journal of Internal Medicine |
| spelling | doaj-art-3459a4e1df464930ae908b33d1b382212024-11-11T08:39:47ZengBabol University of Medical SciencesCaspian Journal of Internal Medicine2008-61642008-61722025-10-01161165168Galectin-3 Marker Expression in Renal Cell Carcinoma and Correlation with patient Clinicopathologic Factors: A cross-sectional studyGhodsieh Kamrani0Reza Havaspour1Mohammad Ranaee2Hamid Shafi3Hoda Shirafkan4Mohammad Ebrahim Sohrabi5Davoud Jahansouz6 Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Department of Pathology, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran Fatemeh Zahra Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Background: Renal Cell Carcinoma is one of the most common malignancies worldwide. To date, multiple attempts had been made to accurately diagnose it and predict its behavior. One of the most intriguing biomarkers that have been assessed since 90s, is galectin-3. This study aimed to increase the prior knowledge of galectin-3 expression association with patient's clinicopathologic factors. Methods: In this single-center cross-sectional study, 71 patient samples from hospital archive were assessed for galectin-3 expression by immunohistochemistry assay. Pathologic slides were evaluated for histologic subtype, grade, stage, tumor size, presence of necrosis, and invasion of the renal vein. By adding cytoplasmic staining score to the color intensity score, a final score was recorded as galectin-3 positivity score. Results: 88 pathological slides of patients with confirmed RCC were screened and 71 were finally assessed. The mean age of the patients was 58.52 years (lowest 30 and highest 87). 67.6% were males and 32.4% were females. 68% of tumors were clear cell carcinoma, and only one oncocytoma was present. All 9 chromophobe cases showed a strong galectin-3 expression. Except for female gender (47.8% vs 18.8% in men; P=0.01), no statistically significant association was found between patient age, tumor grade, tumor size, tumor stage, and renal vein invasion with the level of galectin-3 expression. Conclusion: Considering the contradictory findings between this study and other similar studies, it can be concluded that the physiological role of galectins is very complex and the need for larger and more comprehensive evaluations is felt.http://caspjim.com/article-1-4326-en.pdfgalectin 3kidney neoplasmsgalectins |
| spellingShingle | Ghodsieh Kamrani Reza Havaspour Mohammad Ranaee Hamid Shafi Hoda Shirafkan Mohammad Ebrahim Sohrabi Davoud Jahansouz Galectin-3 Marker Expression in Renal Cell Carcinoma and Correlation with patient Clinicopathologic Factors: A cross-sectional study Caspian Journal of Internal Medicine galectin 3 kidney neoplasms galectins |
| title | Galectin-3 Marker Expression in Renal Cell Carcinoma and Correlation with patient Clinicopathologic Factors: A cross-sectional study |
| title_full | Galectin-3 Marker Expression in Renal Cell Carcinoma and Correlation with patient Clinicopathologic Factors: A cross-sectional study |
| title_fullStr | Galectin-3 Marker Expression in Renal Cell Carcinoma and Correlation with patient Clinicopathologic Factors: A cross-sectional study |
| title_full_unstemmed | Galectin-3 Marker Expression in Renal Cell Carcinoma and Correlation with patient Clinicopathologic Factors: A cross-sectional study |
| title_short | Galectin-3 Marker Expression in Renal Cell Carcinoma and Correlation with patient Clinicopathologic Factors: A cross-sectional study |
| title_sort | galectin 3 marker expression in renal cell carcinoma and correlation with patient clinicopathologic factors a cross sectional study |
| topic | galectin 3 kidney neoplasms galectins |
| url | http://caspjim.com/article-1-4326-en.pdf |
| work_keys_str_mv | AT ghodsiehkamrani galectin3markerexpressioninrenalcellcarcinomaandcorrelationwithpatientclinicopathologicfactorsacrosssectionalstudy AT rezahavaspour galectin3markerexpressioninrenalcellcarcinomaandcorrelationwithpatientclinicopathologicfactorsacrosssectionalstudy AT mohammadranaee galectin3markerexpressioninrenalcellcarcinomaandcorrelationwithpatientclinicopathologicfactorsacrosssectionalstudy AT hamidshafi galectin3markerexpressioninrenalcellcarcinomaandcorrelationwithpatientclinicopathologicfactorsacrosssectionalstudy AT hodashirafkan galectin3markerexpressioninrenalcellcarcinomaandcorrelationwithpatientclinicopathologicfactorsacrosssectionalstudy AT mohammadebrahimsohrabi galectin3markerexpressioninrenalcellcarcinomaandcorrelationwithpatientclinicopathologicfactorsacrosssectionalstudy AT davoudjahansouz galectin3markerexpressioninrenalcellcarcinomaandcorrelationwithpatientclinicopathologicfactorsacrosssectionalstudy |