Vitamin C potentiates the killing of Mycobacterium tuberculosis by bedaquiline through metabolic disruption

Vitamin C potentiates the killing of Mycobacterium tuberculosis by bedaquiline through metabolic disruption

ABSTRACT Tuberculosis (TB), a disease caused by the bacterium Mycobacterium tuberculosis (Mtb), continues to pose a major global health threat, exacerbated by the emergence of drug-resistant strains and the lengthy treatment regimens required for effective management. Bedaquiline (BDQ), a key compon...

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Bibliographic Details
Main Authors: Catherine Vilchèze, Saranathan Rajagopalan, Raja Sab Kalluru, Niaz Banaei, William R. Jacobs
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:mBio
Subjects:
tuberculosis
bedaquiline
persistence
antibiotics
sterilization
metabolism
Online Access:https://journals.asm.org/doi/10.1128/mbio.01484-25
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