ATM in immunobiology: From lymphocyte development to cancer immunotherapy
Ataxia Telangiectasia Mutated (ATM) is a protein kinase traditionally known for its role in DNA damage response and cell cycle regulation. However, emerging research has revealed its multifaceted and crucial functions in the immune system. This comprehensive review explores the diverse roles of ATM...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Translational Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523324003942 |
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| author | Ji-Hoon Lee |
| author_facet | Ji-Hoon Lee |
| author_sort | Ji-Hoon Lee |
| collection | DOAJ |
| description | Ataxia Telangiectasia Mutated (ATM) is a protein kinase traditionally known for its role in DNA damage response and cell cycle regulation. However, emerging research has revealed its multifaceted and crucial functions in the immune system. This comprehensive review explores the diverse roles of ATM in immune regulation, from lymphocyte development to its involvement in cancer immunotherapy. The review describes ATM's critical functions in V(D)J recombination and class switch recombination, highlighting its importance in adaptive immunity. It examines ATM's role in innate immunity, particularly in NF-κB signaling and cytokine production. Furthermore, the review analyzes the impact of ATM deficiency on oxidative stress and mitochondrial function in immune cells, providing insights into the immunological defects observed in Ataxia Telangiectasia (A-T). The article explores ATM's significance in maintaining hematopoietic stem cell function and its implications for bone marrow transplantation and gene therapy. Additionally, it addresses ATM's involvement in inflammation and immune senescence, linking DNA damage response to age-related immune decline. Finally, this review highlights the emerging role of ATM in cancer immunotherapy, where its inhibition shows promise in enhancing immune checkpoint blockade therapy. This review synthesizes current knowledge on ATM's functions in the immune system, offering insights into the pathophysiology of ATM-related disorders and potential therapeutic strategies for immune-related conditions and cancer immunotherapy. |
| format | Article |
| id | doaj-art-34558bcc3d71478ca9c712bd8b5f0adc |
| institution | Kabale University |
| issn | 1936-5233 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj-art-34558bcc3d71478ca9c712bd8b5f0adc2025-01-22T05:41:33ZengElsevierTranslational Oncology1936-52332025-02-0152102268ATM in immunobiology: From lymphocyte development to cancer immunotherapyJi-Hoon Lee0Department of Biological Sciences, Research Center of Ecomimetics, Chonnam National University, Gwangju 61186, South KoreaAtaxia Telangiectasia Mutated (ATM) is a protein kinase traditionally known for its role in DNA damage response and cell cycle regulation. However, emerging research has revealed its multifaceted and crucial functions in the immune system. This comprehensive review explores the diverse roles of ATM in immune regulation, from lymphocyte development to its involvement in cancer immunotherapy. The review describes ATM's critical functions in V(D)J recombination and class switch recombination, highlighting its importance in adaptive immunity. It examines ATM's role in innate immunity, particularly in NF-κB signaling and cytokine production. Furthermore, the review analyzes the impact of ATM deficiency on oxidative stress and mitochondrial function in immune cells, providing insights into the immunological defects observed in Ataxia Telangiectasia (A-T). The article explores ATM's significance in maintaining hematopoietic stem cell function and its implications for bone marrow transplantation and gene therapy. Additionally, it addresses ATM's involvement in inflammation and immune senescence, linking DNA damage response to age-related immune decline. Finally, this review highlights the emerging role of ATM in cancer immunotherapy, where its inhibition shows promise in enhancing immune checkpoint blockade therapy. This review synthesizes current knowledge on ATM's functions in the immune system, offering insights into the pathophysiology of ATM-related disorders and potential therapeutic strategies for immune-related conditions and cancer immunotherapy.http://www.sciencedirect.com/science/article/pii/S1936523324003942ATMAtaxia-TelangiectasiaLymphocyte developmentInnate immunityOxidative stressHematopoietic stem cells |
| spellingShingle | Ji-Hoon Lee ATM in immunobiology: From lymphocyte development to cancer immunotherapy Translational Oncology ATM Ataxia-Telangiectasia Lymphocyte development Innate immunity Oxidative stress Hematopoietic stem cells |
| title | ATM in immunobiology: From lymphocyte development to cancer immunotherapy |
| title_full | ATM in immunobiology: From lymphocyte development to cancer immunotherapy |
| title_fullStr | ATM in immunobiology: From lymphocyte development to cancer immunotherapy |
| title_full_unstemmed | ATM in immunobiology: From lymphocyte development to cancer immunotherapy |
| title_short | ATM in immunobiology: From lymphocyte development to cancer immunotherapy |
| title_sort | atm in immunobiology from lymphocyte development to cancer immunotherapy |
| topic | ATM Ataxia-Telangiectasia Lymphocyte development Innate immunity Oxidative stress Hematopoietic stem cells |
| url | http://www.sciencedirect.com/science/article/pii/S1936523324003942 |
| work_keys_str_mv | AT jihoonlee atminimmunobiologyfromlymphocytedevelopmenttocancerimmunotherapy |