Therapeutic potential of extracellular vesicles in inflammatory diseases
Extracellular vesicles are spherical lipid bilayer vesicles composed of lipids, proteins and nucleic acids that could deliver signaling molecules into target cells to regulate their function and biological processes. Recently, increasing numbers of studies have demonstrated the therapeutic potential...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Extracellular Vesicle |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2773041724000258 |
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| author | Xiaojian Huang Shen Zhang Zhenzhen Wang |
| author_facet | Xiaojian Huang Shen Zhang Zhenzhen Wang |
| author_sort | Xiaojian Huang |
| collection | DOAJ |
| description | Extracellular vesicles are spherical lipid bilayer vesicles composed of lipids, proteins and nucleic acids that could deliver signaling molecules into target cells to regulate their function and biological processes. Recently, increasing numbers of studies have demonstrated the therapeutic potential of extracellular vesicles (EVs) in inflammatory diseases by migrating the inflammatory responses and ameliorating physiological deteriorations, as well as promoting angiogenesis and mediating immune responses. In this review, we mainly focused on the biological and molecular functions of EVs in anti-inflammatory activity and their protective roles in many kinds of inflammation diseases, including pneumonia, neuroinflammatory diseases, inflammatory bowel disease, osteoarthritis, rheumatoid arthritis, cardiovascular disease, dry eye disease, periodontitis, diabetic wounds and systemic lupus erythematosus. Furthermore, we further summarized the underlying therapeutic mechanisms of EVs in inflammatory diseases and discussed the current challenges and future perspectives of EVs in clinical applications, providing an insight into the potential of EVs as therapeutic agent for other diseases. |
| format | Article |
| id | doaj-art-3452b6c53af54a65a02eb56eb1657b28 |
| institution | OA Journals |
| issn | 2773-0417 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Extracellular Vesicle |
| spelling | doaj-art-3452b6c53af54a65a02eb56eb1657b282025-08-20T02:33:35ZengElsevierExtracellular Vesicle2773-04172025-06-01510005810.1016/j.vesic.2024.100058Therapeutic potential of extracellular vesicles in inflammatory diseasesXiaojian Huang0Shen Zhang1Zhenzhen Wang2School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, 511442, PR China; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, PR ChinaSchool of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, 511442, PR China; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, PR ChinaSchool of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, 511442, PR China; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, PR China; Corresponding author. School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, 511442, PR China.Extracellular vesicles are spherical lipid bilayer vesicles composed of lipids, proteins and nucleic acids that could deliver signaling molecules into target cells to regulate their function and biological processes. Recently, increasing numbers of studies have demonstrated the therapeutic potential of extracellular vesicles (EVs) in inflammatory diseases by migrating the inflammatory responses and ameliorating physiological deteriorations, as well as promoting angiogenesis and mediating immune responses. In this review, we mainly focused on the biological and molecular functions of EVs in anti-inflammatory activity and their protective roles in many kinds of inflammation diseases, including pneumonia, neuroinflammatory diseases, inflammatory bowel disease, osteoarthritis, rheumatoid arthritis, cardiovascular disease, dry eye disease, periodontitis, diabetic wounds and systemic lupus erythematosus. Furthermore, we further summarized the underlying therapeutic mechanisms of EVs in inflammatory diseases and discussed the current challenges and future perspectives of EVs in clinical applications, providing an insight into the potential of EVs as therapeutic agent for other diseases.http://www.sciencedirect.com/science/article/pii/S2773041724000258Extracellular vesiclesInflammation diseasesExosomesTherapeutic mechanismAnti-Inflammatory activity |
| spellingShingle | Xiaojian Huang Shen Zhang Zhenzhen Wang Therapeutic potential of extracellular vesicles in inflammatory diseases Extracellular Vesicle Extracellular vesicles Inflammation diseases Exosomes Therapeutic mechanism Anti-Inflammatory activity |
| title | Therapeutic potential of extracellular vesicles in inflammatory diseases |
| title_full | Therapeutic potential of extracellular vesicles in inflammatory diseases |
| title_fullStr | Therapeutic potential of extracellular vesicles in inflammatory diseases |
| title_full_unstemmed | Therapeutic potential of extracellular vesicles in inflammatory diseases |
| title_short | Therapeutic potential of extracellular vesicles in inflammatory diseases |
| title_sort | therapeutic potential of extracellular vesicles in inflammatory diseases |
| topic | Extracellular vesicles Inflammation diseases Exosomes Therapeutic mechanism Anti-Inflammatory activity |
| url | http://www.sciencedirect.com/science/article/pii/S2773041724000258 |
| work_keys_str_mv | AT xiaojianhuang therapeuticpotentialofextracellularvesiclesininflammatorydiseases AT shenzhang therapeuticpotentialofextracellularvesiclesininflammatorydiseases AT zhenzhenwang therapeuticpotentialofextracellularvesiclesininflammatorydiseases |