Copper(II) Inhibition of the SARS‐CoV‐2 Main Protease

Copper(II) Inhibition of the SARS‐CoV‐2 Main Protease

ABSTRACT In an analysis of the structural stability of the coronavirus main protease (Mpro), we identified regions of the protein that could be disabled by cobalt(III)‐cation binding to histidines and cysteines. Here we have extended our work to include copper(II) chelates, which we have docked to H...

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Bibliographic Details
Main Authors: Roberto A. Garza‐López, Liam Kwak, Andrew Chung, Gabriel L. Ancajas, John J. Kozak, Harry B. Gray
Format: Article
Language:English
Published: Wiley-VCH 2025-07-01
Series:Natural Sciences
Subjects:
a) Metal‐based compounds function as inhibitors to combat infectious diseases, including COVID‐19. 
b) Docking and molecular dynamics simulations confirm the stability of Cu(II) chelate binding. 
c) Cu(II) complexes are biologically compatible and could inhibit viruses.  
Online Access:https://doi.org/10.1002/ntls.70012
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https://doi.org/10.1002/ntls.70012

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