Exploring the impact of envelope protein mutations on Chikungunya virus epitopes: Analysis of virus samples from the Alagoas State outbreak, Brazil

Exploring the impact of envelope protein mutations on Chikungunya virus epitopes: Analysis of virus samples from the Alagoas State outbreak, Brazil

Objective: To investigate mutations in the Chikungunya (CHIKV) envelope genome region and evaluate their potential impact on B lymphocyte epitopes via in silico analysis. Methods: E1, E2 and 6K protein genes were sequenced from viral RNA isolated from 13 CHIKV-positive serum samples from Alagoas Sta...

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Main Authors: Jamile Taniele-Silva, Júlia De Andrade Brandão, Maria Júlia Tenório Costa Cinésio De Oliveira, Stephannie Janaina Maia De Souza, Jean Fábio Gomes Ferro, Magliones Carneiro De Lima, Abelardo Silva-Júnior, Ênio José Bassi, Letícia Anderson
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-06-01
Series:Asian Pacific Journal of Tropical Medicine
Subjects:
genomic variations
in silico analysis
epitope prediction
glycoprotein mutations
Online Access:https://journals.lww.com/10.4103/apjtm.apjtm_746_24
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