Ziziphus spina-christi alleviates paracetamol-induced hepatorenal toxicity in rats through in vivo and computational approaches

Ziziphus spina-christi alleviates paracetamol-induced hepatorenal toxicity in rats through in vivo and computational approaches

Abstract Paracetamol (PCM) overdose is a leading cause of drug-induced liver and kidney injury, necessitating effective therapeutic strategies. This study aimed to evaluate the protective effects of Ziziphus spina-christi (ZSC), a traditional medicinal plant with documented antioxidant and protectiv...

Full description

Saved in:

Bibliographic Details
Main Authors:	Ehsan Kh. M. Khedre, Amany M. M. Hegab, Amira A. El-Mahis, Amina A. S. Abdel Rahman, Sherien H. B. Elwakeel, Ali S. Abdelhameed, Vittorio Calabrese, Ursula M. Jacob, Eman S. G. Hassan
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-08-01
Series:	Scientific Reports
Subjects:	Ziziphus spina-christi NF-κB/TNF-α signaling pathway Bax/Bcl-2/caspase-3 signaling pathway ERK/JNK/p38 MAPK signaling pathway Molecular docking
Online Access:	https://doi.org/10.1038/s41598-025-14454-6
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Toxicity evaluation of Ziziphus spina-christi fruit on Wistar rats
by: Khadija Aliyu Nuru, et al.
Published: (2024-03-01)

UTILIZING OF HPLC TECHNIQUE FOR QUALITATIVE AND QUANTITATIVE IDENTIFICATION OF SOME SECONDARY COMPOUNDS IN THE BARK AND WOOD OF Ziziphus spina-christi L. GROWING IN MOSUL
by: Talal Al-Takay
Published: (2018-06-01)

Impact of Egyptian and Saudi Ziziphus spina-christi L. (Sidr) pulp incorporation on the nutritional, functional, and sensory properties of protein bars
by: Ebtehal A. Altamim
Published: (2025-07-01)

Studi In Silico Aktivitas Analog Senyawa Zizyphine dari Bidara Arab (Zizyphus spina-christi) sebagai Antivirus SARS-CoV-2 terhadap Reseptor 3CLpro
by: Taufik Muhammad Fakih, et al.
Published: (2022-02-01)

Diosgenin Induces Apoptosis of MCF-7 Cells by Regulating DAXX Subcellular Localization and Activating JNK/p38 Signaling Pathway
by: Jia WANG, et al.
Published: (2025-05-01)

Physicochemical Properties, Chemical Composition, Antioxidant Properties, and Antibacterial Effects of Four Palestinian Honey Varieties
by: Basheer Abu-Farich, et al.
Published: (2024-12-01)

JNK3 inhibitors as promising pharmaceuticals with neuroprotective properties
by: Yibeini Wu, et al.
Published: (2024-12-01)

Habitat Suitability of Ziziphus spina‐christi and Ziziphus nummularia in a Changing Climate in the Khalijo‐Omanian Zone, Iran
by: Saeed Behzadi, et al.
Published: (2025-05-01)

GC-MS Analysis and Potential Apoptotic Effect of Paliurus spina-christi Mill. Leaf and Flower Extracts against Breast Cancer Cells
by: Çisil Çamlı Pulat, et al.
Published: (2022-04-01)

Genetic Markers of Spina Bifida: Enrichment of Pathogenic Variants and Variants of Uncertain Significance
by: Jyoti Sharma, et al.
Published: (2025-03-01)

Evaluating the hepatoprotective effects of polyherbal extracts a comprehensive study on liver function and health in rat
by: A.A. Ammari, et al.
Published: (2025-07-01)

Fullerene and apoptosis
by: M. A. Orlova, et al.
Published: (2014-07-01)

HEIX1 Mutation Effects on Endoplasmic Reticulum Stress, Caspase Activation, and JNK2 Pathways
by: MA Dragh, et al.
Published: (2025-03-01)

Kuoxin Decoction Alleviated Left Ventricular Remodeling by Inhibiting Cardiomyocyte Apoptosis Through ASK1/JNK/Cx43 Signaling Pathway in cTnTR141W Transgenic Mice and in vitro
by: Ma M, et al.
Published: (2025-08-01)

Oral Combined Probiotics Clostridium butyricum and Akkermansia muciniphila Inhibits the Progression of 4T1 Breast Cancer by Activating Bcl‐2/Bax Pathway
by: Xiaowei Li, et al.
Published: (2025-06-01)

Genetic alterations in melanoma
by: Đunjić Marija, et al.
Published: (2025-01-01)

Microbiota-derived metabolites in tumorigenesis: mechanistic insights and therapeutic implications
by: Si-Fu Yang, et al.
Published: (2025-05-01)

TIMM8B promotes oxidative phosphorylation and glycolysis by inhibiting the mtROS/ASK1/JNK signaling pathway in ovarian cancer
by: Yue Jia, et al.
Published: (2025-07-01)

Upregulation of GSTP1 mediated by chimeric TFE3 promotes TFE3-tRCC progression by targeting JNK signaling pathway
by: Weixu Chen, et al.
Published: (2024-12-01)

The protective effect of naringenin on ulcerative colitis in mice through increasing Nrf2 pathway activity
by: Li Jiaxiang, et al.
Published: (2025-03-01)

Tumor stem cells from glioblastoma multiforme
by: Z. N. Nikiforova, et al.
Published: (2016-06-01)

Paliurus spina-christi Mill fruit extracts improve glucose uptake and activate the insulin signaling pathways in HepG2 insulin-resistant cells
by: Seyedeh Mona Mousavi Esfahani, et al.
Published: (2023-05-01)

Equilibrium, Kinetic, and Thermodynamic Study of Removing Methyl Orange Dye from Aqueous Solution Using Zizphus spina-christi Leaf Powder
by: Fadya F. Mohammed
Published: (2023-04-01)

Molecular mechanism, diagnosis, and treatment of VACTERL association
by: Manluan Sun, et al.
Published: (2025-07-01)

Roles of MAPK and Nrf2 signaling pathways in quercetin alleviating redox imbalance induced by hydrogen peroxide in mammary epithelial cells
by: Yongxin Li, et al.
Published: (2024-01-01)

Bioinformatics reveals TNFAIP6 as a candidate gene and suggests its potential crosstalk in the treatment of hemodialysis in chronic kidney disease
by: Guoxin Zhang, et al.
Published: (2025-12-01)

Integrative multi-omics study identifies sex-specific molecular signatures and immune modulation in bladder cancer
by: Yizhou Wang, et al.
Published: (2025-05-01)

N-acetylcysteine increased the growth performance of Leuciscus waleckii by improving mitochondrial function, enhancing antioxidant and anti-inflammatory, and inhibiting apoptosis in the hepatopancreas and intestine
by: Deng Lai Li, et al.
Published: (2025-03-01)

The role of the Notch signaling pathway in rhabdomyosarcomas
by: Datis Kalali, et al.
Published: (2025-07-01)

RETRACTED ARTICLE: High-mobility group box chromosomal protein-1 deletion alleviates osteoporosis in OVX rat model via suppressing the osteoclastogenesis and inflammation
by: Haotao Yu, et al.
Published: (2022-04-01)

Interactions Between Bovine Respiratory Syncytial Virus and Cattle: Aspects of Pathogenesis and Immunity
by: Lariane da Silva Barcelos, et al.
Published: (2024-11-01)

Molecular regulatory mechanisms of dietary supplementation with Regel powder to improve muscle development and meat quality in Angus calves
by: Wangjing Liu, et al.
Published: (2025-08-01)

Phosphoproteomic analyses reveal novel cross‐modulation mechanisms between two signaling pathways in yeast
by: Stefania Vaga, et al.
Published: (2014-12-01)

The orchestrated feature of Cornus kousa fruit and gut microbiota against obesity via integrated pharmacology
by: Ki‐Kwang Oh, et al.
Published: (2024-09-01)

Estradiol Reverses Ovariectomy-Induced Disruption of Hypothalamic Gene Expression and Behavior via Modulation of Gonadotropin Releasing Hormone and Calcium Signaling Pathways
by: Asim Muhammad, et al.
Published: (2025-05-01)

Oleanolic Acid@SPIONs Alleviates Lipid-Oxidative Stress Injury of Zebrafish Blood Vessels via Regulating the Expression of JNK and MAPK Signaling Pathways in Vascular Endothelial Cells
by: Gao H, et al.
Published: (2025-04-01)

Hippo/YAP signaling’s multifaceted crosstalk in cancer
by: Jie Zhang, et al.
Published: (2025-07-01)

Notch Signaling Suppression by Golden Phytochemicals: Potential for Cancer Therapy
by: Masoumeh Kaveh Zenjanab, et al.
Published: (2024-07-01)

Bioinformatics Analysis of Candidate Genes Related to Fat Deposition in Yaks at Different Energy Levels
by: Boxuan Yang, et al.
Published: (2025-05-01)

Shape memory bone screws loading L-arginine and Ca2+ propagate mechanical stimulation, energize bone cells and augment bone regeneration
by: Huaqian Liu, et al.
Published: (2025-11-01)