Role of S100 Proteins in Colorectal Carcinogenesis
The family of S100 proteins represents 25 relatively small (9–13 kD) calcium binding proteins. These proteins possess a broad spectrum of important intracellular and extracellular functions. Colorectal cancer is the third most common cancer in men (after lung and prostate cancer) and the second most...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/2632703 |
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| author | Paula Moravkova Darina Kohoutova Stanislav Rejchrt Jiri Cyrany Jan Bures |
| author_facet | Paula Moravkova Darina Kohoutova Stanislav Rejchrt Jiri Cyrany Jan Bures |
| author_sort | Paula Moravkova |
| collection | DOAJ |
| description | The family of S100 proteins represents 25 relatively small (9–13 kD) calcium binding proteins. These proteins possess a broad spectrum of important intracellular and extracellular functions. Colorectal cancer is the third most common cancer in men (after lung and prostate cancer) and the second most frequent cancer in women (after breast cancer) worldwide. S100 proteins are involved in the colorectal carcinogenesis through different mechanisms: they enable proliferation, invasion, and migration of the tumour cells; furthermore, S100 proteins increase angiogenesis and activate NF-κβ signaling pathway, which plays a key role in the molecular pathogenesis especially of colitis-associated carcinoma. The expression of S100 proteins in the cancerous tissue and serum levels of S100 proteins might be used as a precise diagnostic and prognostic marker in patients with suspected or already diagnosed colorectal neoplasia. Possibly, in the future, S100 proteins will be a therapeutic target for tailored anticancer therapy. |
| format | Article |
| id | doaj-art-34323402481849df92478b1df52a1c2c |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-34323402481849df92478b1df52a1c2c2025-02-03T05:59:53ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/26327032632703Role of S100 Proteins in Colorectal CarcinogenesisPaula Moravkova0Darina Kohoutova1Stanislav Rejchrt2Jiri Cyrany3Jan Bures42nd Department of Internal Medicine-Gastroenterology, Charles University in Praha, Faculty of Medicine at Hradec Kralove, University Teaching Hospital, Sokolska 581, 500 05 Hradec Kralove, Czech Republic2nd Department of Internal Medicine-Gastroenterology, Charles University in Praha, Faculty of Medicine at Hradec Kralove, University Teaching Hospital, Sokolska 581, 500 05 Hradec Kralove, Czech Republic2nd Department of Internal Medicine-Gastroenterology, Charles University in Praha, Faculty of Medicine at Hradec Kralove, University Teaching Hospital, Sokolska 581, 500 05 Hradec Kralove, Czech Republic2nd Department of Internal Medicine-Gastroenterology, Charles University in Praha, Faculty of Medicine at Hradec Kralove, University Teaching Hospital, Sokolska 581, 500 05 Hradec Kralove, Czech Republic2nd Department of Internal Medicine-Gastroenterology, Charles University in Praha, Faculty of Medicine at Hradec Kralove, University Teaching Hospital, Sokolska 581, 500 05 Hradec Kralove, Czech RepublicThe family of S100 proteins represents 25 relatively small (9–13 kD) calcium binding proteins. These proteins possess a broad spectrum of important intracellular and extracellular functions. Colorectal cancer is the third most common cancer in men (after lung and prostate cancer) and the second most frequent cancer in women (after breast cancer) worldwide. S100 proteins are involved in the colorectal carcinogenesis through different mechanisms: they enable proliferation, invasion, and migration of the tumour cells; furthermore, S100 proteins increase angiogenesis and activate NF-κβ signaling pathway, which plays a key role in the molecular pathogenesis especially of colitis-associated carcinoma. The expression of S100 proteins in the cancerous tissue and serum levels of S100 proteins might be used as a precise diagnostic and prognostic marker in patients with suspected or already diagnosed colorectal neoplasia. Possibly, in the future, S100 proteins will be a therapeutic target for tailored anticancer therapy.http://dx.doi.org/10.1155/2016/2632703 |
| spellingShingle | Paula Moravkova Darina Kohoutova Stanislav Rejchrt Jiri Cyrany Jan Bures Role of S100 Proteins in Colorectal Carcinogenesis Gastroenterology Research and Practice |
| title | Role of S100 Proteins in Colorectal Carcinogenesis |
| title_full | Role of S100 Proteins in Colorectal Carcinogenesis |
| title_fullStr | Role of S100 Proteins in Colorectal Carcinogenesis |
| title_full_unstemmed | Role of S100 Proteins in Colorectal Carcinogenesis |
| title_short | Role of S100 Proteins in Colorectal Carcinogenesis |
| title_sort | role of s100 proteins in colorectal carcinogenesis |
| url | http://dx.doi.org/10.1155/2016/2632703 |
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