Molecular Mechanisms Underlying Resistance to <i>Bacillus thuringiensis</i> Cry Toxins in Lepidopteran Pests: An Updated Research Perspective
Genetically modified crops that produce insecticidal proteins from <i>Bacillus thuringiensis</i> (<i>Bt</i>) are currently the most efficient and safest method of pest control worldwide. However, the prolonged planting period has led to a reduction in the efficacy of <i>...
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MDPI AG
2025-01-01
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| Series: | Agronomy |
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| Online Access: | https://www.mdpi.com/2073-4395/15/1/155 |
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| author | Deqin Hu Dongmei Wang Hongsheng Pan Xiaoning Liu |
| author_facet | Deqin Hu Dongmei Wang Hongsheng Pan Xiaoning Liu |
| author_sort | Deqin Hu |
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| description | Genetically modified crops that produce insecticidal proteins from <i>Bacillus thuringiensis</i> (<i>Bt</i>) are currently the most efficient and safest method of pest control worldwide. However, the prolonged planting period has led to a reduction in the efficacy of <i>Bt</i> crops due to the evolution of pest resistance in the field. This review paper examines the resistance status of lepidopteran pests to <i>Bt</i> crops under field conditions, elucidates the molecular mechanism underlying their resistance to <i>Bt</i> Cry toxins, and discusses resistance management strategies based on these mechanisms. Extensive research has demonstrated that mutations and alterations in expression patterns of midgut receptor genes are closely associated with <i>Bt</i> resistance. As our understanding of molecular mechanisms progresses, several innovative approaches such as DNA molecular detection techniques, engineering modified Cry toxins, and combining <i>Bt</i> toxin with RNAi technology have been developed for effective pest control measures. Future research will further unravel the intricate molecular mechanisms underlying this phenomenon to develop scientifically sound integrated pest management strategies. |
| format | Article |
| id | doaj-art-34317755a1ae469a8870f0dce81349d7 |
| institution | Kabale University |
| issn | 2073-4395 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Agronomy |
| spelling | doaj-art-34317755a1ae469a8870f0dce81349d72025-01-24T13:16:57ZengMDPI AGAgronomy2073-43952025-01-0115115510.3390/agronomy15010155Molecular Mechanisms Underlying Resistance to <i>Bacillus thuringiensis</i> Cry Toxins in Lepidopteran Pests: An Updated Research PerspectiveDeqin Hu0Dongmei Wang1Hongsheng Pan2Xiaoning Liu3Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, ChinaNational Plant Protection Scientific Observation and Experiment Station of Korla, Institute of Plant Protection, Xinjiang Academy of Agricultural Sciences, Urumqi 830091, ChinaNational Plant Protection Scientific Observation and Experiment Station of Korla, Institute of Plant Protection, Xinjiang Academy of Agricultural Sciences, Urumqi 830091, ChinaXinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, ChinaGenetically modified crops that produce insecticidal proteins from <i>Bacillus thuringiensis</i> (<i>Bt</i>) are currently the most efficient and safest method of pest control worldwide. However, the prolonged planting period has led to a reduction in the efficacy of <i>Bt</i> crops due to the evolution of pest resistance in the field. This review paper examines the resistance status of lepidopteran pests to <i>Bt</i> crops under field conditions, elucidates the molecular mechanism underlying their resistance to <i>Bt</i> Cry toxins, and discusses resistance management strategies based on these mechanisms. Extensive research has demonstrated that mutations and alterations in expression patterns of midgut receptor genes are closely associated with <i>Bt</i> resistance. As our understanding of molecular mechanisms progresses, several innovative approaches such as DNA molecular detection techniques, engineering modified Cry toxins, and combining <i>Bt</i> toxin with RNAi technology have been developed for effective pest control measures. Future research will further unravel the intricate molecular mechanisms underlying this phenomenon to develop scientifically sound integrated pest management strategies.https://www.mdpi.com/2073-4395/15/1/155<i>Bacillus thuringiensis</i>resistance mechanismresistance managementlepidopteran pests |
| spellingShingle | Deqin Hu Dongmei Wang Hongsheng Pan Xiaoning Liu Molecular Mechanisms Underlying Resistance to <i>Bacillus thuringiensis</i> Cry Toxins in Lepidopteran Pests: An Updated Research Perspective Agronomy <i>Bacillus thuringiensis</i> resistance mechanism resistance management lepidopteran pests |
| title | Molecular Mechanisms Underlying Resistance to <i>Bacillus thuringiensis</i> Cry Toxins in Lepidopteran Pests: An Updated Research Perspective |
| title_full | Molecular Mechanisms Underlying Resistance to <i>Bacillus thuringiensis</i> Cry Toxins in Lepidopteran Pests: An Updated Research Perspective |
| title_fullStr | Molecular Mechanisms Underlying Resistance to <i>Bacillus thuringiensis</i> Cry Toxins in Lepidopteran Pests: An Updated Research Perspective |
| title_full_unstemmed | Molecular Mechanisms Underlying Resistance to <i>Bacillus thuringiensis</i> Cry Toxins in Lepidopteran Pests: An Updated Research Perspective |
| title_short | Molecular Mechanisms Underlying Resistance to <i>Bacillus thuringiensis</i> Cry Toxins in Lepidopteran Pests: An Updated Research Perspective |
| title_sort | molecular mechanisms underlying resistance to i bacillus thuringiensis i cry toxins in lepidopteran pests an updated research perspective |
| topic | <i>Bacillus thuringiensis</i> resistance mechanism resistance management lepidopteran pests |
| url | https://www.mdpi.com/2073-4395/15/1/155 |
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