Relationship Between Thyroid Dysfunction and Ovarian Cancer
This review looks at the causes of the association between thyroid dysfunction (hyperthyroidism and hypothyroidism) and ovarian cancer (OC) risk. Epidemiological data have revealed that thyroid dysfunction, particularly hyperthyroidism, is associated with increased risk, progression, and mortality i...
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| Format: | Article |
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2025-06-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/15/6/870 |
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| author | Justyna Gogola-Mruk Aleksandra Sirek Izabela Kumor Gabriela Wojtaszek Klaudia Roszak Karolina Kulig Anna Ptak |
| author_facet | Justyna Gogola-Mruk Aleksandra Sirek Izabela Kumor Gabriela Wojtaszek Klaudia Roszak Karolina Kulig Anna Ptak |
| author_sort | Justyna Gogola-Mruk |
| collection | DOAJ |
| description | This review looks at the causes of the association between thyroid dysfunction (hyperthyroidism and hypothyroidism) and ovarian cancer (OC) risk. Epidemiological data have revealed that thyroid dysfunction, particularly hyperthyroidism, is associated with increased risk, progression, and mortality in patients with OC. In addition, research studies and databases have demonstrated that both the expression and localization of thyroid hormone receptors alpha (TRα) and beta (TRβ) and membrane thyroid hormone receptor integrin alpha V beta 3 (αvβ3) affect OC progression and survival in OC patients. Furthermore, this review described the levels of the thyroid hormones (THs) thyroxine (T<sub>4</sub>) and 3,5,3′-triiodo-L-thyronine (T<sub>3</sub>) in the blood of OC patients and their role in OC progression. Moreover, we present studies that reported the relationship between hyperthyroidism and hypothyroidism and the levels of metabolic hormones in the blood and the possible effects on metabolic reprogramming in OC cells. We also report data indicating the relationship between the treatment of thyroid dysfunction and OC progression. Finally, the cited case studies described the essential case of struma ovarii, which is OC, including thyroid tissue. This review describes the link between thyroid dysfunction and OC risk and progression, which may be important in treating OC patients with thyroid dysfunction. |
| format | Article |
| id | doaj-art-342fd241530b4369be515db87793dc76 |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-342fd241530b4369be515db87793dc762025-08-20T03:27:28ZengMDPI AGBiomolecules2218-273X2025-06-0115687010.3390/biom15060870Relationship Between Thyroid Dysfunction and Ovarian CancerJustyna Gogola-Mruk0Aleksandra Sirek1Izabela Kumor2Gabriela Wojtaszek3Klaudia Roszak4Karolina Kulig5Anna Ptak6Laboratory of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Gronostajowa 9, PL 30387 Cracow, PolandLaboratory of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Gronostajowa 9, PL 30387 Cracow, PolandLaboratory of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Gronostajowa 9, PL 30387 Cracow, PolandLaboratory of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Gronostajowa 9, PL 30387 Cracow, PolandLaboratory of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Gronostajowa 9, PL 30387 Cracow, PolandLaboratory of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Gronostajowa 9, PL 30387 Cracow, PolandLaboratory of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Gronostajowa 9, PL 30387 Cracow, PolandThis review looks at the causes of the association between thyroid dysfunction (hyperthyroidism and hypothyroidism) and ovarian cancer (OC) risk. Epidemiological data have revealed that thyroid dysfunction, particularly hyperthyroidism, is associated with increased risk, progression, and mortality in patients with OC. In addition, research studies and databases have demonstrated that both the expression and localization of thyroid hormone receptors alpha (TRα) and beta (TRβ) and membrane thyroid hormone receptor integrin alpha V beta 3 (αvβ3) affect OC progression and survival in OC patients. Furthermore, this review described the levels of the thyroid hormones (THs) thyroxine (T<sub>4</sub>) and 3,5,3′-triiodo-L-thyronine (T<sub>3</sub>) in the blood of OC patients and their role in OC progression. Moreover, we present studies that reported the relationship between hyperthyroidism and hypothyroidism and the levels of metabolic hormones in the blood and the possible effects on metabolic reprogramming in OC cells. We also report data indicating the relationship between the treatment of thyroid dysfunction and OC progression. Finally, the cited case studies described the essential case of struma ovarii, which is OC, including thyroid tissue. This review describes the link between thyroid dysfunction and OC risk and progression, which may be important in treating OC patients with thyroid dysfunction.https://www.mdpi.com/2218-273X/15/6/870hypothyroidismhyperthyroidismovarian cancerthyroid hormonesthyroid hormone receptors |
| spellingShingle | Justyna Gogola-Mruk Aleksandra Sirek Izabela Kumor Gabriela Wojtaszek Klaudia Roszak Karolina Kulig Anna Ptak Relationship Between Thyroid Dysfunction and Ovarian Cancer Biomolecules hypothyroidism hyperthyroidism ovarian cancer thyroid hormones thyroid hormone receptors |
| title | Relationship Between Thyroid Dysfunction and Ovarian Cancer |
| title_full | Relationship Between Thyroid Dysfunction and Ovarian Cancer |
| title_fullStr | Relationship Between Thyroid Dysfunction and Ovarian Cancer |
| title_full_unstemmed | Relationship Between Thyroid Dysfunction and Ovarian Cancer |
| title_short | Relationship Between Thyroid Dysfunction and Ovarian Cancer |
| title_sort | relationship between thyroid dysfunction and ovarian cancer |
| topic | hypothyroidism hyperthyroidism ovarian cancer thyroid hormones thyroid hormone receptors |
| url | https://www.mdpi.com/2218-273X/15/6/870 |
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