SARS-CoV-2 Variants Screening in Burkina Faso

SARS-CoV-2 Variants Screening in Burkina Faso

Introduction: In Sub-Saharan Africa, the data on the mutations and variants of circulating SARS-CoV-2 is limited. This study aimed to screen specific mutations and variants of SARS-CoV-2 circulating in Burkina Faso. Methods: This study included symptomatic and asymptomatic individuals who underwe...

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Main Authors: Serge Théophile Soubeiga1*, Kinda Charlotte2, Abdou Azaque Zoure1, Tegwinde Rebeca Compaoré1, Sylvie Zida1, Alidou Kagambega1, Tani Sagna1, Charlemagne Dabiré1, Oumarou Ouedraogo1, Nadiyah Lasisi2, Alexia Kabore2, Farida Milène Zida1, Binta Fofana1, Stéphane Somé2, Abdoul Nikiema1, Dinanibè Kambire1, Dramane Zongo1, Issiaka Soulama1, Charles Sawadogo3, Sandrine Gampini4, Henri Gautier Ouedraogo1
Format: Article
Language:English
Published: Pasteur Institute of Iran 2022-09-01
Series:Journal of Medical Microbiology and Infectious Diseases
Subjects:
sars-cov-2
rt-pcr
ct
variant
mutation
burkina faso
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Summary:Introduction: In Sub-Saharan Africa, the data on the mutations and variants of circulating SARS-CoV-2 is limited. This study aimed to screen specific mutations and variants of SARS-CoV-2 circulating in Burkina Faso. Methods: This study included symptomatic and asymptomatic individuals who underwent diagnostic testing for SARS-CoV-2 by RT-PCR on nasopharyngeal and oropharyngeal swabs from 7 December 2021 to 12 January 2022. Samples from individuals with a Ct value ≤ 33 were selected for the variants-specific mutation screening. The screening was performed using two kits, “SNPsig® SARS-COV- 2 (Escape PLEX)" and "SNPsig® VariPLEX™ (COVID-19) Real-Time PCR Assay". Results: SARS-CoV-2 prevalence was 18.9% (332/1758). A total of 113 samples (34.04%) had a Ct value less than (≤ 33), with only 20.35% (23/113) belonging to symptomatic patients. The mean age was 39.01±13 years. The Beta variant (B.1.351) was the most detected one comprising 78.8% (89/113) of variants. Gamma and Delta variants were detected at a low proportion of 0.9% (1/113). No mutation or variant was detected in seven (6.2%) samples. Conclusion: Specific mutation screening detected Beta (B.1.351), Gamma (P.1), and Delta (B.1.617.2) variants of SARS-CoV-2 circulating in Burkina Faso. The absence of mutations in some samples might suggest variants other than those detected.
ISSN:2345-5349
2345-5330

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